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Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy.
Int J Obstet Anesth. 2011 Jul; 20(3):236-9.IJ

Abstract

BACKGROUND

The postoperative analgesic effects of rectal indomethacin and tramadol were compared in patients undergoing elective termination of first trimester pregnancy and diagnostic dilatation and curettage.

METHODS

Eighty-one American Society of Anesthesiologists class I and II women undergoing first trimester termination of pregnancy or diagnostic dilation and curettage were randomly allocated to receive rectal suppositories of either tramadol 100 mg (n=41) or indomethacin 100 mg (n=40) 90 min before induction of anesthesia. Pain scores and side effects were evaluated until discharge. Intraoperative anesthetic and postoperative analgesic consumption was also recorded. Intravenous metamizole 1 g was employed for postoperative rescue analgesia.

RESULTS

When compared to the indomethacin group, the tramadol group required less intraoperative propofol [136 mg ±28 vs. 160 mg ±35 (P=0.001)], less rescue analgesia [2.4% vs. 22% (P=0.005)] and lower visual analogue pain scores [2.4 ±8 vs. 23 ±22 (P=0.005)]. The incidence of postoperative nausea and vomiting was similar in both groups.

CONCLUSION

When compared to indomethacin 100 mg, preoperative administration of tramadol 100 mg provides superior postoperative analgesia with minimal adverse effects.

Authors+Show Affiliations

Department of Anesthesia, Edith Wolfson Medical Center, Holon, Affiliated with Sackler Medical School, Tel Aviv University, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21640574

Citation

Khazin, V, et al. "Postoperative Analgesia With Tramadol and Indomethacin for Diagnostic Curettage and Early Termination of Pregnancy." International Journal of Obstetric Anesthesia, vol. 20, no. 3, 2011, pp. 236-9.
Khazin V, Weitzman S, Rozenzvit-Podles E, et al. Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy. Int J Obstet Anesth. 2011;20(3):236-9.
Khazin, V., Weitzman, S., Rozenzvit-Podles, E., Ezri, T., Debby, A., Golan, A., & Evron, S. (2011). Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy. International Journal of Obstetric Anesthesia, 20(3), 236-9. https://doi.org/10.1016/j.ijoa.2011.03.002
Khazin V, et al. Postoperative Analgesia With Tramadol and Indomethacin for Diagnostic Curettage and Early Termination of Pregnancy. Int J Obstet Anesth. 2011;20(3):236-9. PubMed PMID: 21640574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postoperative analgesia with tramadol and indomethacin for diagnostic curettage and early termination of pregnancy. AU - Khazin,V, AU - Weitzman,S, AU - Rozenzvit-Podles,E, AU - Ezri,T, AU - Debby,A, AU - Golan,A, AU - Evron,S, Y1 - 2011/06/02/ PY - 2010/04/17/received PY - 2010/11/24/revised PY - 2011/03/05/accepted PY - 2011/6/7/entrez PY - 2011/6/7/pubmed PY - 2011/10/28/medline SP - 236 EP - 9 JF - International journal of obstetric anesthesia JO - Int J Obstet Anesth VL - 20 IS - 3 N2 - BACKGROUND: The postoperative analgesic effects of rectal indomethacin and tramadol were compared in patients undergoing elective termination of first trimester pregnancy and diagnostic dilatation and curettage. METHODS: Eighty-one American Society of Anesthesiologists class I and II women undergoing first trimester termination of pregnancy or diagnostic dilation and curettage were randomly allocated to receive rectal suppositories of either tramadol 100 mg (n=41) or indomethacin 100 mg (n=40) 90 min before induction of anesthesia. Pain scores and side effects were evaluated until discharge. Intraoperative anesthetic and postoperative analgesic consumption was also recorded. Intravenous metamizole 1 g was employed for postoperative rescue analgesia. RESULTS: When compared to the indomethacin group, the tramadol group required less intraoperative propofol [136 mg ±28 vs. 160 mg ±35 (P=0.001)], less rescue analgesia [2.4% vs. 22% (P=0.005)] and lower visual analogue pain scores [2.4 ±8 vs. 23 ±22 (P=0.005)]. The incidence of postoperative nausea and vomiting was similar in both groups. CONCLUSION: When compared to indomethacin 100 mg, preoperative administration of tramadol 100 mg provides superior postoperative analgesia with minimal adverse effects. SN - 1532-3374 UR - https://www.unboundmedicine.com/medline/citation/21640574/Postoperative_analgesia_with_tramadol_and_indomethacin_for_diagnostic_curettage_and_early_termination_of_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-289X(11)00024-0 DB - PRIME DP - Unbound Medicine ER -