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Prosthetic joint infection caused by gram-negative organisms.
J Arthroplasty 2011; 26(6 Suppl):104-8JA

Abstract

Traditionally, periprosthetic joint infections (PJIs) due to gram-negative organisms are considered more difficult to manage; however, little literature exists with regard to outcome of PJI caused by gram-negative organisms. We identified 277 patients with 282 culture-positive PJI receiving surgical treatment. Thirty-one joints were treated for gram-negative PJI. The gram-negative group was then compared with the gram-positive and polymicrobial PJI. A single debridement and retention of prosthesis were successful in 70% (7/10) of isolated gram negative compared with 33.3% (13/39) of methicillin-sensitive gram positive, 48.9% (23/47) of methicillin-resistant gram positive, and 57.1% (4/7) of polymicrobial. Of those patients undergoing a planned 2-stage exchange, a successful reimplantation was performed in 52% (12/23) of gram-negative, 51% (52/103) of methicillin-resistant gram-positive, 69% (65/94) of methicillin-sensitive gram-positive, and 0% (0/8) of polymicrobial PJI cases. These results indicate that PJI due to gram-negative pathogens, although less common, is difficult to treat and is associated with limited success.

Authors+Show Affiliations

Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21641762

Citation

Zmistowski, Benjamin, et al. "Prosthetic Joint Infection Caused By Gram-negative Organisms." The Journal of Arthroplasty, vol. 26, no. 6 Suppl, 2011, pp. 104-8.
Zmistowski B, Fedorka CJ, Sheehan E, et al. Prosthetic joint infection caused by gram-negative organisms. J Arthroplasty. 2011;26(6 Suppl):104-8.
Zmistowski, B., Fedorka, C. J., Sheehan, E., Deirmengian, G., Austin, M. S., & Parvizi, J. (2011). Prosthetic joint infection caused by gram-negative organisms. The Journal of Arthroplasty, 26(6 Suppl), pp. 104-8. doi:10.1016/j.arth.2011.03.044.
Zmistowski B, et al. Prosthetic Joint Infection Caused By Gram-negative Organisms. J Arthroplasty. 2011;26(6 Suppl):104-8. PubMed PMID: 21641762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prosthetic joint infection caused by gram-negative organisms. AU - Zmistowski,Benjamin, AU - Fedorka,Catherine J, AU - Sheehan,Eoin, AU - Deirmengian,Gregory, AU - Austin,Matthew S, AU - Parvizi,Javad, Y1 - 2011/06/08/ PY - 2011/01/13/received PY - 2011/03/31/accepted PY - 2011/6/7/entrez PY - 2011/6/7/pubmed PY - 2012/1/27/medline SP - 104 EP - 8 JF - The Journal of arthroplasty JO - J Arthroplasty VL - 26 IS - 6 Suppl N2 - Traditionally, periprosthetic joint infections (PJIs) due to gram-negative organisms are considered more difficult to manage; however, little literature exists with regard to outcome of PJI caused by gram-negative organisms. We identified 277 patients with 282 culture-positive PJI receiving surgical treatment. Thirty-one joints were treated for gram-negative PJI. The gram-negative group was then compared with the gram-positive and polymicrobial PJI. A single debridement and retention of prosthesis were successful in 70% (7/10) of isolated gram negative compared with 33.3% (13/39) of methicillin-sensitive gram positive, 48.9% (23/47) of methicillin-resistant gram positive, and 57.1% (4/7) of polymicrobial. Of those patients undergoing a planned 2-stage exchange, a successful reimplantation was performed in 52% (12/23) of gram-negative, 51% (52/103) of methicillin-resistant gram-positive, 69% (65/94) of methicillin-sensitive gram-positive, and 0% (0/8) of polymicrobial PJI cases. These results indicate that PJI due to gram-negative pathogens, although less common, is difficult to treat and is associated with limited success. SN - 1532-8406 UR - https://www.unboundmedicine.com/medline/citation/21641762/Prosthetic_joint_infection_caused_by_gram_negative_organisms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0883-5403(11)00156-2 DB - PRIME DP - Unbound Medicine ER -