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Diffusion tensor imaging findings are not strongly associated with postconcussional disorder 2 months following mild traumatic brain injury.
J Head Trauma Rehabil. 2012 May-Jun; 27(3):188-98.JH

Abstract

OBJECTIVE

To examine the relation between diffusion tensor imaging (DTI) of the corpus callosum and postconcussion symptom reporting following mild traumatic brain injury (MTBI).

PARTICIPANTS

Sixty patients with MTBI and 34 patients with orthopedic/soft-tissue injuries (Trauma Controls) prospectively enrolled from consecutive admissions to a level 1 trauma center.

PROCEDURE

Diffusion tensor imaging of the corpus callosum was undertaken using a Phillips 3T scanner at 6 to 8 weeks postinjury. Participants also completed a postconcussion symptom checklist. The MTBI group was divided into 2 subgroups based on the International Classification of Diseases, Tenth Revision symptom criteria for postconcussion disorder (PCD): PCD Present (n = 21), PCD Absent (n = 39).

MAIN OUTCOME MEASURES

Measures of fractional anisotropy and mean diffusivity for the genu, body, and splenium of the corpus callosum. Participants also completed the British Columbia Post-Concussion Symptom Inventory.

RESULTS

The MTBI group reported more postconcussion symptoms than the trauma controls. There were no significant differences between MTBI and trauma control groups on all DTI measures. In the MTBI sample, there were no significant differences on all DTI measures between those who did and did not meet the International Classification of Diseases, Tenth Revision research criteria for postconcussion disorder.

CONCLUSIONS

These data do not support an association between white matter integrity in the corpus callosum and self-reported postconcussion syndrome 6 to 8 weeks post-MTBI.

Authors+Show Affiliations

Defense and Veterans Brain Injury Center, Walter Reed Army Medical Center, Washington, DC 20307, USA. rlange@dvbic.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21642855

Citation

Lange, Rael T., et al. "Diffusion Tensor Imaging Findings Are Not Strongly Associated With Postconcussional Disorder 2 Months Following Mild Traumatic Brain Injury." The Journal of Head Trauma Rehabilitation, vol. 27, no. 3, 2012, pp. 188-98.
Lange RT, Iverson GL, Brubacher JR, et al. Diffusion tensor imaging findings are not strongly associated with postconcussional disorder 2 months following mild traumatic brain injury. J Head Trauma Rehabil. 2012;27(3):188-98.
Lange, R. T., Iverson, G. L., Brubacher, J. R., Mädler, B., & Heran, M. K. (2012). Diffusion tensor imaging findings are not strongly associated with postconcussional disorder 2 months following mild traumatic brain injury. The Journal of Head Trauma Rehabilitation, 27(3), 188-98. https://doi.org/10.1097/HTR.0b013e318217f0ad
Lange RT, et al. Diffusion Tensor Imaging Findings Are Not Strongly Associated With Postconcussional Disorder 2 Months Following Mild Traumatic Brain Injury. J Head Trauma Rehabil. 2012 May-Jun;27(3):188-98. PubMed PMID: 21642855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffusion tensor imaging findings are not strongly associated with postconcussional disorder 2 months following mild traumatic brain injury. AU - Lange,Rael T, AU - Iverson,Grant L, AU - Brubacher,Jeffrey R, AU - Mädler,Burkhard, AU - Heran,Manraj K, PY - 2011/6/7/entrez PY - 2011/6/7/pubmed PY - 2012/9/15/medline SP - 188 EP - 98 JF - The Journal of head trauma rehabilitation JO - J Head Trauma Rehabil VL - 27 IS - 3 N2 - OBJECTIVE: To examine the relation between diffusion tensor imaging (DTI) of the corpus callosum and postconcussion symptom reporting following mild traumatic brain injury (MTBI). PARTICIPANTS: Sixty patients with MTBI and 34 patients with orthopedic/soft-tissue injuries (Trauma Controls) prospectively enrolled from consecutive admissions to a level 1 trauma center. PROCEDURE: Diffusion tensor imaging of the corpus callosum was undertaken using a Phillips 3T scanner at 6 to 8 weeks postinjury. Participants also completed a postconcussion symptom checklist. The MTBI group was divided into 2 subgroups based on the International Classification of Diseases, Tenth Revision symptom criteria for postconcussion disorder (PCD): PCD Present (n = 21), PCD Absent (n = 39). MAIN OUTCOME MEASURES: Measures of fractional anisotropy and mean diffusivity for the genu, body, and splenium of the corpus callosum. Participants also completed the British Columbia Post-Concussion Symptom Inventory. RESULTS: The MTBI group reported more postconcussion symptoms than the trauma controls. There were no significant differences between MTBI and trauma control groups on all DTI measures. In the MTBI sample, there were no significant differences on all DTI measures between those who did and did not meet the International Classification of Diseases, Tenth Revision research criteria for postconcussion disorder. CONCLUSIONS: These data do not support an association between white matter integrity in the corpus callosum and self-reported postconcussion syndrome 6 to 8 weeks post-MTBI. SN - 1550-509X UR - https://www.unboundmedicine.com/medline/citation/21642855/Diffusion_tensor_imaging_findings_are_not_strongly_associated_with_postconcussional_disorder_2_months_following_mild_traumatic_brain_injury_ L2 - https://doi.org/10.1097/HTR.0b013e318217f0ad DB - PRIME DP - Unbound Medicine ER -