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Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner.

Abstract

Endocannabinoids are involved in excitatory neurotransmission initiated by glutamate and aspartate. The aim of the present study was to investigate the effects of the cannabinoid agonists, Δ(9)-THC and WIN55,212-2, on tissue (prefrontal cortex, dorsal striatum, nucleus accumbens, hippocampus, amygdala and hypothalamus) levels of glutamate and aspartate in two rat phenotypes, high responders (HR) and low responders (LR), differentiated according to their response to a novel environment. HR displayed increased motor activity but no difference in basal levels of glutamate and aspartate as compared to LR. Both cannabinoids increased ambulatory activity at the low doses, this effect was observed only in HR following Δ(9)-THC, but in both HR and LR following WIN55,212-2. The cannabinoids primarily increased glutamate levels in the prefrontal cortex, dorsal striatum, nucleus accumbens and hippocampus, while the high dose of WIN55,212-2 decreased glutamate levels in the amygdala and both doses in the hypothalamus; these effects appeared overall more pronounced in HR. In contrast, the cannabinoids primarily decreased aspartate levels in all brain regions, except in the dorsal striatum, where an increase was seen after both doses of Δ(9)-THC and WIN55,212-2 as well as in the nucleus accumbens after the low dose of Δ(9)-THC in HR; these effects also appeared overall more pronounced in HR. Present results show that exogenous cannabinoids affect tissue levels of glutamate and aspartate in a phenotype-, compound-, dose-, and brain region-dependent manner.

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  • Authors+Show Affiliations

    ,

    Department of Pharmacology, Medical School, University of Ioannina, 45110 Ioannina, Greece.

    , , ,

    Source

    Behavioural brain research 224:1 2011 Oct 10 pg 65-72

    MeSH

    Analgesics
    Analysis of Variance
    Animals
    Benzoxazines
    Brain
    Dose-Response Relationship, Drug
    Dronabinol
    Excitatory Amino Acids
    Hyperkinesis
    Male
    Morpholines
    Motor Activity
    Naphthalenes
    Rats
    Rats, Sprague-Dawley

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21645556

    Citation

    Galanopoulos, A, et al. "Δ(9)-THC and WIN55,212-2 Affect Brain Tissue Levels of Excitatory Amino Acids in a Phenotype-, Compound-, Dose-, and Region-specific Manner." Behavioural Brain Research, vol. 224, no. 1, 2011, pp. 65-72.
    Galanopoulos A, Polissidis A, Papadopoulou-Daifoti Z, et al. Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner. Behav Brain Res. 2011;224(1):65-72.
    Galanopoulos, A., Polissidis, A., Papadopoulou-Daifoti, Z., Nomikos, G. G., & Antoniou, K. (2011). Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner. Behavioural Brain Research, 224(1), pp. 65-72. doi:10.1016/j.bbr.2011.05.018.
    Galanopoulos A, et al. Δ(9)-THC and WIN55,212-2 Affect Brain Tissue Levels of Excitatory Amino Acids in a Phenotype-, Compound-, Dose-, and Region-specific Manner. Behav Brain Res. 2011 Oct 10;224(1):65-72. PubMed PMID: 21645556.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner. AU - Galanopoulos,A, AU - Polissidis,A, AU - Papadopoulou-Daifoti,Z, AU - Nomikos,G G, AU - Antoniou,K, Y1 - 2011/05/27/ PY - 2011/04/03/received PY - 2011/05/16/revised PY - 2011/05/22/accepted PY - 2011/6/8/entrez PY - 2011/6/8/pubmed PY - 2011/12/13/medline SP - 65 EP - 72 JF - Behavioural brain research JO - Behav. Brain Res. VL - 224 IS - 1 N2 - Endocannabinoids are involved in excitatory neurotransmission initiated by glutamate and aspartate. The aim of the present study was to investigate the effects of the cannabinoid agonists, Δ(9)-THC and WIN55,212-2, on tissue (prefrontal cortex, dorsal striatum, nucleus accumbens, hippocampus, amygdala and hypothalamus) levels of glutamate and aspartate in two rat phenotypes, high responders (HR) and low responders (LR), differentiated according to their response to a novel environment. HR displayed increased motor activity but no difference in basal levels of glutamate and aspartate as compared to LR. Both cannabinoids increased ambulatory activity at the low doses, this effect was observed only in HR following Δ(9)-THC, but in both HR and LR following WIN55,212-2. The cannabinoids primarily increased glutamate levels in the prefrontal cortex, dorsal striatum, nucleus accumbens and hippocampus, while the high dose of WIN55,212-2 decreased glutamate levels in the amygdala and both doses in the hypothalamus; these effects appeared overall more pronounced in HR. In contrast, the cannabinoids primarily decreased aspartate levels in all brain regions, except in the dorsal striatum, where an increase was seen after both doses of Δ(9)-THC and WIN55,212-2 as well as in the nucleus accumbens after the low dose of Δ(9)-THC in HR; these effects also appeared overall more pronounced in HR. Present results show that exogenous cannabinoids affect tissue levels of glutamate and aspartate in a phenotype-, compound-, dose-, and brain region-dependent manner. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/21645556/abstract/Δ_9__THC_and_WIN55212_2_affect_brain_tissue_levels_of_excitatory_amino_acids_in_a_phenotype__compound__dose__and_region_specific_manner_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(11)00407-4 DB - PRIME DP - Unbound Medicine ER -