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Effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma model.
Int Arch Allergy Immunol. 2011; 155 Suppl 1:90-5.IA

Abstract

BACKGROUND

Little is known about the role of the cysteinyl leukotriene (cysLT) 2 receptor in the pathophysiology of asthma. The aim of this study is to investigate the effects of a cysLT1 receptor antagonist (montelukast) and a dual cysLT1/2 receptor antagonist (BAY-u9773) on airway hypersensitivity and airway inflammation induced by antigen challenge in ovalbumin (OVA)-sensitized guinea pigs.

METHODS

Male Hartley guinea pigs sensitized with OVA were intraperitoneally administered 0.1, 1, or 10 mg/kg of montelukast or 0.1 mg/kg of BAY-u9773 and then challenged with inhaled OVA. Airway reactivity to acetylcholine, inflammatory cells in bronchoalveolar lavage (BAL) fluid, and eosinophil infiltration in airway walls after OVA challenge were evaluated.

RESULTS

Pretreatment with 1 or 10 mg/kg, but not 0.1 mg/kg, of montelukast significantly suppressed airway hypersensitivity and eosinophil infiltration into the BAL fluid. Moreover, 0.1 mg/kg of BAY-u9773 significantly suppressed the development of these markers. The suppressive effects of BAY-u9773, although not significantly different, trended toward being greater than those of montelukast. Although all of the doses of montelukast tested and 0.1 mg/kg of BAY-u9773 significantly suppressed eosinophil infiltration in airway walls, the suppressive effect of BAY-u9773 was significantly greater than that of 0.1 mg/kg of montelukast.

CONCLUSION

Signaling may contribute to the pathophysiology of asthma via the cysLT1/2 receptor.

Authors+Show Affiliations

Department of Respiratory Medicine and Allergology, Nara Hospital, Kinki University Faculty of Medicine, Ikoma, Japan. muraki@nara.med.kindai.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21646802

Citation

Muraki, Masato, et al. "Effects of a Cysteinyl Leukotriene Dual 1/2 Receptor Antagonist On Antigen-induced Airway Hypersensitivity and Airway Inflammation in a Guinea Pig Asthma Model." International Archives of Allergy and Immunology, vol. 155 Suppl 1, 2011, pp. 90-5.
Muraki M, Imbe S, Santo H, et al. Effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma model. Int Arch Allergy Immunol. 2011;155 Suppl 1:90-5.
Muraki, M., Imbe, S., Santo, H., Sato, R., Sano, H., Iwanaga, T., & Tohda, Y. (2011). Effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma model. International Archives of Allergy and Immunology, 155 Suppl 1, 90-5. https://doi.org/10.1159/000327439
Muraki M, et al. Effects of a Cysteinyl Leukotriene Dual 1/2 Receptor Antagonist On Antigen-induced Airway Hypersensitivity and Airway Inflammation in a Guinea Pig Asthma Model. Int Arch Allergy Immunol. 2011;155 Suppl 1:90-5. PubMed PMID: 21646802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma model. AU - Muraki,Masato, AU - Imbe,Shu, AU - Santo,Hiroshi, AU - Sato,Ryuji, AU - Sano,Hiroyuki, AU - Iwanaga,Takashi, AU - Tohda,Yuji, Y1 - 2011/06/01/ PY - 2011/6/8/entrez PY - 2011/6/10/pubmed PY - 2011/7/14/medline SP - 90 EP - 5 JF - International archives of allergy and immunology JO - Int. Arch. Allergy Immunol. VL - 155 Suppl 1 N2 - BACKGROUND: Little is known about the role of the cysteinyl leukotriene (cysLT) 2 receptor in the pathophysiology of asthma. The aim of this study is to investigate the effects of a cysLT1 receptor antagonist (montelukast) and a dual cysLT1/2 receptor antagonist (BAY-u9773) on airway hypersensitivity and airway inflammation induced by antigen challenge in ovalbumin (OVA)-sensitized guinea pigs. METHODS: Male Hartley guinea pigs sensitized with OVA were intraperitoneally administered 0.1, 1, or 10 mg/kg of montelukast or 0.1 mg/kg of BAY-u9773 and then challenged with inhaled OVA. Airway reactivity to acetylcholine, inflammatory cells in bronchoalveolar lavage (BAL) fluid, and eosinophil infiltration in airway walls after OVA challenge were evaluated. RESULTS: Pretreatment with 1 or 10 mg/kg, but not 0.1 mg/kg, of montelukast significantly suppressed airway hypersensitivity and eosinophil infiltration into the BAL fluid. Moreover, 0.1 mg/kg of BAY-u9773 significantly suppressed the development of these markers. The suppressive effects of BAY-u9773, although not significantly different, trended toward being greater than those of montelukast. Although all of the doses of montelukast tested and 0.1 mg/kg of BAY-u9773 significantly suppressed eosinophil infiltration in airway walls, the suppressive effect of BAY-u9773 was significantly greater than that of 0.1 mg/kg of montelukast. CONCLUSION: Signaling may contribute to the pathophysiology of asthma via the cysLT1/2 receptor. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/21646802/Effects_of_a_cysteinyl_leukotriene_dual_1/2_receptor_antagonist_on_antigen_induced_airway_hypersensitivity_and_airway_inflammation_in_a_guinea_pig_asthma_model_ L2 - https://www.karger.com?DOI=10.1159/000327439 DB - PRIME DP - Unbound Medicine ER -