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Fosinopril and losartan regulate klotho gene and nicotinamide adenine dinucleotide phosphate oxidase expression in kidneys of spontaneously hypertensive rats.
Kidney Blood Press Res. 2011; 34(5):350-7.KB

Abstract

BACKGROUND/AIMS

Klotho, a newly identified antiaging gene, predominantly detected in the kidney, has pleiotropic protective effects on kidney diseases. Several studies have confirmed the association between Klotho and oxidative stress. The present studies were performed to explore effects of fosinopril (Fos) and losartan (Los) on Klotho and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression in kidneys of spontaneously hypertensive rats (SHR).

METHODS

Twenty-four male 22-week-old SHR were randomly divided into three groups: model group, Fos group and Los group. Wistar-Kyoto rats were taken as control. After 8 weeks, urinary N-acetyl-β-D-glucosaminidase (NAGase), 24 h urinary protein (Upro), serum creatinine (Scr), blood urea nitrogen (BUN) and renal pathological changes were detected. Renal mRNA and protein expression of Klotho and three subunits of NADPH oxidase protein expression were evaluated.

RESULTS

As compared to the model group, NAGase, Upro, Scr and BUN were decreased; the typical renal pathological damage was relieved in the Fos or Los group. Fos or Los inhibited the reduction of Klotho expression, and reduced the elevation of NADPH oxidase expression.

CONCLUSION

Abnormal expression of Klotho and NADPH oxidase plays important roles in progression of hypertensive renal damage. Fos and Los can increase Klotho expression, and inhibit NADPH oxidase expression, which may be one of the mechanisms of their protective effects in hypertensive renal damage.

Authors+Show Affiliations

Department of Nephrology, Xiangya Hospital, Xiangya Medical College, Central South University, Changsha, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21646815

Citation

Tang, Rong, et al. "Fosinopril and Losartan Regulate Klotho Gene and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Expression in Kidneys of Spontaneously Hypertensive Rats." Kidney & Blood Pressure Research, vol. 34, no. 5, 2011, pp. 350-7.
Tang R, Zhou QL, Ao X, et al. Fosinopril and losartan regulate klotho gene and nicotinamide adenine dinucleotide phosphate oxidase expression in kidneys of spontaneously hypertensive rats. Kidney Blood Press Res. 2011;34(5):350-7.
Tang, R., Zhou, Q. L., Ao, X., Peng, W. S., Veeraragoo, P., & Tang, T. F. (2011). Fosinopril and losartan regulate klotho gene and nicotinamide adenine dinucleotide phosphate oxidase expression in kidneys of spontaneously hypertensive rats. Kidney & Blood Pressure Research, 34(5), 350-7. https://doi.org/10.1159/000326806
Tang R, et al. Fosinopril and Losartan Regulate Klotho Gene and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Expression in Kidneys of Spontaneously Hypertensive Rats. Kidney Blood Press Res. 2011;34(5):350-7. PubMed PMID: 21646815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fosinopril and losartan regulate klotho gene and nicotinamide adenine dinucleotide phosphate oxidase expression in kidneys of spontaneously hypertensive rats. AU - Tang,Rong, AU - Zhou,Qiao-Ling, AU - Ao,Xiang, AU - Peng,Wei-Sheng, AU - Veeraragoo,Pouranan, AU - Tang,Tian-Feng, Y1 - 2011/06/03/ PY - 2010/10/25/received PY - 2011/02/25/accepted PY - 2011/6/8/entrez PY - 2011/6/8/pubmed PY - 2012/6/5/medline SP - 350 EP - 7 JF - Kidney & blood pressure research JO - Kidney Blood Press Res VL - 34 IS - 5 N2 - BACKGROUND/AIMS: Klotho, a newly identified antiaging gene, predominantly detected in the kidney, has pleiotropic protective effects on kidney diseases. Several studies have confirmed the association between Klotho and oxidative stress. The present studies were performed to explore effects of fosinopril (Fos) and losartan (Los) on Klotho and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression in kidneys of spontaneously hypertensive rats (SHR). METHODS: Twenty-four male 22-week-old SHR were randomly divided into three groups: model group, Fos group and Los group. Wistar-Kyoto rats were taken as control. After 8 weeks, urinary N-acetyl-β-D-glucosaminidase (NAGase), 24 h urinary protein (Upro), serum creatinine (Scr), blood urea nitrogen (BUN) and renal pathological changes were detected. Renal mRNA and protein expression of Klotho and three subunits of NADPH oxidase protein expression were evaluated. RESULTS: As compared to the model group, NAGase, Upro, Scr and BUN were decreased; the typical renal pathological damage was relieved in the Fos or Los group. Fos or Los inhibited the reduction of Klotho expression, and reduced the elevation of NADPH oxidase expression. CONCLUSION: Abnormal expression of Klotho and NADPH oxidase plays important roles in progression of hypertensive renal damage. Fos and Los can increase Klotho expression, and inhibit NADPH oxidase expression, which may be one of the mechanisms of their protective effects in hypertensive renal damage. SN - 1423-0143 UR - https://www.unboundmedicine.com/medline/citation/21646815/Fosinopril_and_losartan_regulate_klotho_gene_and_nicotinamide_adenine_dinucleotide_phosphate_oxidase_expression_in_kidneys_of_spontaneously_hypertensive_rats_ L2 - https://www.karger.com?DOI=10.1159/000326806 DB - PRIME DP - Unbound Medicine ER -