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A review: role of ultraviolet radiation in age-related macular degeneration.

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness in the western world. The retina is highly susceptible to photochemical damage from continuous exposure of light and oxygen. The cornea and the lens block a major portion of the ultraviolet (UV) radiation from reaching the retina (<295 nm). The relationship between UV light exposure and AMD is unclear, although short wavelength radiation and the blue light induce significant oxidative stress to the retinal pigment epithelium. Epidemiologic evidence indicates a trend toward association between severity of light exposure and AMD. In this review, we discuss type 1 and type 2 photochemical damage that occurs in response to UV exposure. We examine the impact of different doses of exposure to UV radiation and the subsequent production of oxidative stress in AMD. Local and systemic protective mechanisms of the retina including antioxidant enzymes and macular pigments are reviewed. This article provides a review of possible cellular and molecular effects of UV radiation exposure in AMD and potential therapies that may prevent blindness resulting from this disease.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Ophthalmology, University of Florida-College of Medicine, Jacksonville, FL 32209, USA. kchalam@jax.ufl.edu

    , ,

    Source

    Eye & contact lens 37:4 2011 Jul pg 225-32

    MeSH

    Aging
    Global Health
    Humans
    Incidence
    Macular Degeneration
    Oxidative Stress
    Retina
    Risk Factors
    Ultraviolet Rays

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21646979

    Citation

    Chalam, K V., et al. "A Review: Role of Ultraviolet Radiation in Age-related Macular Degeneration." Eye & Contact Lens, vol. 37, no. 4, 2011, pp. 225-32.
    Chalam KV, Khetpal V, Rusovici R, et al. A review: role of ultraviolet radiation in age-related macular degeneration. Eye Contact Lens. 2011;37(4):225-32.
    Chalam, K. V., Khetpal, V., Rusovici, R., & Balaiya, S. (2011). A review: role of ultraviolet radiation in age-related macular degeneration. Eye & Contact Lens, 37(4), pp. 225-32. doi:10.1097/ICL.0b013e31821fbd3e.
    Chalam KV, et al. A Review: Role of Ultraviolet Radiation in Age-related Macular Degeneration. Eye Contact Lens. 2011;37(4):225-32. PubMed PMID: 21646979.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A review: role of ultraviolet radiation in age-related macular degeneration. AU - Chalam,K V, AU - Khetpal,Vijay, AU - Rusovici,Raluca, AU - Balaiya,Sankarathi, PY - 2011/6/8/entrez PY - 2011/6/8/pubmed PY - 2011/12/13/medline SP - 225 EP - 32 JF - Eye & contact lens JO - Eye Contact Lens VL - 37 IS - 4 N2 - Age-related macular degeneration (AMD) is a leading cause of blindness in the western world. The retina is highly susceptible to photochemical damage from continuous exposure of light and oxygen. The cornea and the lens block a major portion of the ultraviolet (UV) radiation from reaching the retina (<295 nm). The relationship between UV light exposure and AMD is unclear, although short wavelength radiation and the blue light induce significant oxidative stress to the retinal pigment epithelium. Epidemiologic evidence indicates a trend toward association between severity of light exposure and AMD. In this review, we discuss type 1 and type 2 photochemical damage that occurs in response to UV exposure. We examine the impact of different doses of exposure to UV radiation and the subsequent production of oxidative stress in AMD. Local and systemic protective mechanisms of the retina including antioxidant enzymes and macular pigments are reviewed. This article provides a review of possible cellular and molecular effects of UV radiation exposure in AMD and potential therapies that may prevent blindness resulting from this disease. SN - 1542-233X UR - https://www.unboundmedicine.com/medline/citation/21646979/A_review:_role_of_ultraviolet_radiation_in_age_related_macular_degeneration_ L2 - http://Insights.ovid.com/pubmed?pmid=21646979 DB - PRIME DP - Unbound Medicine ER -