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The correlation of serum trace elements and heavy metals with carotid artery atherosclerosis in maintenance hemodialysis patients.
Biol Trace Elem Res 2011; 144(1-3):351-9BT

Abstract

Changes in essential trace elements and heavy metals may affect the atherosclerotic state of patients on maintenance hemodialysis (HD). The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, lead, and copper/zinc ratio) and carotid artery intima-media thickness (CIMT) in HD patients. Fifty chronic HD patients without known atherosclerotic disease and 48 age- and sex-matched healthy individuals were included in the study. The serum levels of trace elements (iron, zinc, manganese, copper, and magnesium) and heavy metals (cobalt, cadmium, and lead) were measured by Atomic Adsorption Spectrophotometer (UNICAM-929). CIMT was assessed by carotid artery ultrasonography. The serum levels of iron, zinc, and manganese were lower; levels of copper, magnesium, cobalt, cadmium, lead, and copper/zinc ratio were higher in HD patients compared to controls. CIMT in HD patients were higher than the control group (0.64 ± 0.11 vs 0.42 ± 0.05, p < 0.001). There was a significant negative correlation between CIMT and serum levels of zinc (r = -0.70, p < 0.01), iron (r = -0.71, p < 0.01), and manganese (r = -0.47, p < 0.01), while there was a significant positive correlation between CIMT and serum levels of copper (r = 0.63, p < 0.01), magnesium (r = 0.77, p < 0.01), cobalt (r = 0.63, p < 0.01), cadmium (r = 0.48, p < 0.01), lead (r = 0.38, p < 0.01), and copper/zinc ratio (r = 0.68, p < 0.01). A linear regression analysis showed that serum levels of magnesium, cadmium, lead, and copper/zinc ratio were still significantly and positively correlated with CIMT. We propose that copper/zinc ratio, magnesium and toxic metals cadmium and lead are independent determinants of CIMT in maintenance HD patients without known atherosclerotic disease.

Authors+Show Affiliations

Department of Nephrology, Van Yuksek Ihtisas Hospital, 65200, Van, Turkey. elifari@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21647752

Citation

Ari, Elif, et al. "The Correlation of Serum Trace Elements and Heavy Metals With Carotid Artery Atherosclerosis in Maintenance Hemodialysis Patients." Biological Trace Element Research, vol. 144, no. 1-3, 2011, pp. 351-9.
Ari E, Kaya Y, Demir H, et al. The correlation of serum trace elements and heavy metals with carotid artery atherosclerosis in maintenance hemodialysis patients. Biol Trace Elem Res. 2011;144(1-3):351-9.
Ari, E., Kaya, Y., Demir, H., Asicioglu, E., & Keskin, S. (2011). The correlation of serum trace elements and heavy metals with carotid artery atherosclerosis in maintenance hemodialysis patients. Biological Trace Element Research, 144(1-3), pp. 351-9. doi:10.1007/s12011-011-9103-0.
Ari E, et al. The Correlation of Serum Trace Elements and Heavy Metals With Carotid Artery Atherosclerosis in Maintenance Hemodialysis Patients. Biol Trace Elem Res. 2011;144(1-3):351-9. PubMed PMID: 21647752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The correlation of serum trace elements and heavy metals with carotid artery atherosclerosis in maintenance hemodialysis patients. AU - Ari,Elif, AU - Kaya,Yuksel, AU - Demir,Halit, AU - Asicioglu,Ebru, AU - Keskin,Sıddık, Y1 - 2011/06/07/ PY - 2011/04/15/received PY - 2011/05/26/accepted PY - 2011/6/8/entrez PY - 2011/6/8/pubmed PY - 2012/4/28/medline SP - 351 EP - 9 JF - Biological trace element research JO - Biol Trace Elem Res VL - 144 IS - 1-3 N2 - Changes in essential trace elements and heavy metals may affect the atherosclerotic state of patients on maintenance hemodialysis (HD). The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, lead, and copper/zinc ratio) and carotid artery intima-media thickness (CIMT) in HD patients. Fifty chronic HD patients without known atherosclerotic disease and 48 age- and sex-matched healthy individuals were included in the study. The serum levels of trace elements (iron, zinc, manganese, copper, and magnesium) and heavy metals (cobalt, cadmium, and lead) were measured by Atomic Adsorption Spectrophotometer (UNICAM-929). CIMT was assessed by carotid artery ultrasonography. The serum levels of iron, zinc, and manganese were lower; levels of copper, magnesium, cobalt, cadmium, lead, and copper/zinc ratio were higher in HD patients compared to controls. CIMT in HD patients were higher than the control group (0.64 ± 0.11 vs 0.42 ± 0.05, p < 0.001). There was a significant negative correlation between CIMT and serum levels of zinc (r = -0.70, p < 0.01), iron (r = -0.71, p < 0.01), and manganese (r = -0.47, p < 0.01), while there was a significant positive correlation between CIMT and serum levels of copper (r = 0.63, p < 0.01), magnesium (r = 0.77, p < 0.01), cobalt (r = 0.63, p < 0.01), cadmium (r = 0.48, p < 0.01), lead (r = 0.38, p < 0.01), and copper/zinc ratio (r = 0.68, p < 0.01). A linear regression analysis showed that serum levels of magnesium, cadmium, lead, and copper/zinc ratio were still significantly and positively correlated with CIMT. We propose that copper/zinc ratio, magnesium and toxic metals cadmium and lead are independent determinants of CIMT in maintenance HD patients without known atherosclerotic disease. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/21647752/The_correlation_of_serum_trace_elements_and_heavy_metals_with_carotid_artery_atherosclerosis_in_maintenance_hemodialysis_patients_ L2 - https://dx.doi.org/10.1007/s12011-011-9103-0 DB - PRIME DP - Unbound Medicine ER -