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Energy evaluation of the compaction process of directly compressible isomalt.
Ceska Slov Farm. 2011 Feb; 60(1):11-6.CS

Abstract

The paper compares the compressibility of two directly compressible isomalts, galenIQ 720 and galenIQ721, using the energy evaluation of the compaction process by means of the force--displacement profiles. It evaluates the energies for friction, energies accumulated by the tablet, energy of decompression, energy of compaction and plasticity in pure dry binders, in dry binders with lubricants (0.5 and 1% of magnesium stearate and sodium stearyl fumarate) and further in the tableting materials containing the model ingredients acetylsalicylic acid and ascorbic acid. The results of the study have revealed that lower values of the energy for friction and compaction with the identical compression force are found by the substance galenIQ 720, which is therefore better compressible than the substance galenIQ 721.

Authors+Show Affiliations

Muzíková J
Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology, Czech Republic. muzikova@faf.cuni.cz
Pavlasová V
No affiliation info available

MeSH

DisaccharidesMechanical PhenomenaSugar AlcoholsTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21648171

Citation

Muzíková, Jitka, and Veronika Pavlasová. "Energy Evaluation of the Compaction Process of Directly Compressible Isomalt." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 60, no. 1, 2011, pp. 11-6.
Muzíková J, Pavlasová V. Energy evaluation of the compaction process of directly compressible isomalt. Ceska Slov Farm. 2011;60(1):11-6.
Muzíková, J., & Pavlasová, V. (2011). Energy evaluation of the compaction process of directly compressible isomalt. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 60(1), 11-6.
Muzíková J, Pavlasová V. Energy Evaluation of the Compaction Process of Directly Compressible Isomalt. Ceska Slov Farm. 2011;60(1):11-6. PubMed PMID: 21648171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Energy evaluation of the compaction process of directly compressible isomalt. AU - Muzíková,Jitka, AU - Pavlasová,Veronika, PY - 2011/6/9/entrez PY - 2011/6/9/pubmed PY - 2011/6/29/medline SP - 11 EP - 6 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 60 IS - 1 N2 - The paper compares the compressibility of two directly compressible isomalts, galenIQ 720 and galenIQ721, using the energy evaluation of the compaction process by means of the force--displacement profiles. It evaluates the energies for friction, energies accumulated by the tablet, energy of decompression, energy of compaction and plasticity in pure dry binders, in dry binders with lubricants (0.5 and 1% of magnesium stearate and sodium stearyl fumarate) and further in the tableting materials containing the model ingredients acetylsalicylic acid and ascorbic acid. The results of the study have revealed that lower values of the energy for friction and compaction with the identical compression force are found by the substance galenIQ 720, which is therefore better compressible than the substance galenIQ 721. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/21648171/Energy_evaluation_of_the_compaction_process_of_directly_compressible_isomalt_ DB - PRIME DP - Unbound Medicine ER -