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Partial characterization of cobalamin deficiency in Chinese Shar Peis.
Vet J. 2012 Jan; 191(1):41-5.VJ

Abstract

A total of 22,462 serum sample results from dogs being evaluated for gastrointestinal disease at the Gastrointestinal Laboratory, College of Veterinary Medicine, Texas A&M University were evaluated retrospectively. The proportion of dogs with serum cobalamin concentrations below the reference interval and median serum concentrations were compared between Shar Peis and other dog breeds. Serum samples were also obtained prospectively from 22 healthy and 32 Shar Peis with chronic gastrointestinal disease and 59 healthy dogs of other breeds, and serum concentrations of cobalamin, folate, and methylmalonic acid were determined and compared. Overall, 64.0% (89/139) of serum samples from Shar Peis showed serum cobalamin concentrations below the limit of the reference interval and 38.1% (53/139) of these were below the detectable limit for the assay. The median serum cobalamin concentration in Shar Peis was significantly lower than in other breeds. Shar Peis with gastrointestinal disease had significantly lower serum cobalamin and higher serum methylmalonic acid concentrations compared to healthy Shar Peis. Healthy Shar Peis had significantly increased serum methylmalonic acid concentrations compared to healthy dogs of other breeds. There were no meaningful differences in folate concentrations between groups. In conclusion, Shar Peis have a high prevalence of cobalamin deficiency compared to other breeds and healthy Shar Peis may have subclinical cobalamin deficiency.

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Authors+Show Affiliations

Bishop MA
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA. mbishop@cvm.tamu.edu
Xenoulis PG
No affiliation info available
Berghoff N
No affiliation info available
Grützner N
No affiliation info available
Suchodolski JS
No affiliation info available
Steiner JM
No affiliation info available

MeSH

AnimalsDog DiseasesDogsFemaleMalePedigreePrevalenceTexasVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21652239

Citation

Bishop, Micah A., et al. "Partial Characterization of Cobalamin Deficiency in Chinese Shar Peis." Veterinary Journal (London, England : 1997), vol. 191, no. 1, 2012, pp. 41-5.
Bishop MA, Xenoulis PG, Berghoff N, et al. Partial characterization of cobalamin deficiency in Chinese Shar Peis. Vet J. 2012;191(1):41-5.
Bishop, M. A., Xenoulis, P. G., Berghoff, N., Grützner, N., Suchodolski, J. S., & Steiner, J. M. (2012). Partial characterization of cobalamin deficiency in Chinese Shar Peis. Veterinary Journal (London, England : 1997), 191(1), 41-5. https://doi.org/10.1016/j.tvjl.2011.05.008
Bishop MA, et al. Partial Characterization of Cobalamin Deficiency in Chinese Shar Peis. Vet J. 2012;191(1):41-5. PubMed PMID: 21652239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Partial characterization of cobalamin deficiency in Chinese Shar Peis. AU - Bishop,Micah A, AU - Xenoulis,Panagiotis G, AU - Berghoff,Nora, AU - Grützner,Niels, AU - Suchodolski,Jan S, AU - Steiner,Jörg M, Y1 - 2011/06/08/ PY - 2010/11/30/received PY - 2011/05/06/revised PY - 2011/05/07/accepted PY - 2011/6/10/entrez PY - 2011/6/10/pubmed PY - 2012/5/4/medline SP - 41 EP - 5 JF - Veterinary journal (London, England : 1997) JO - Vet J VL - 191 IS - 1 N2 - A total of 22,462 serum sample results from dogs being evaluated for gastrointestinal disease at the Gastrointestinal Laboratory, College of Veterinary Medicine, Texas A&M University were evaluated retrospectively. The proportion of dogs with serum cobalamin concentrations below the reference interval and median serum concentrations were compared between Shar Peis and other dog breeds. Serum samples were also obtained prospectively from 22 healthy and 32 Shar Peis with chronic gastrointestinal disease and 59 healthy dogs of other breeds, and serum concentrations of cobalamin, folate, and methylmalonic acid were determined and compared. Overall, 64.0% (89/139) of serum samples from Shar Peis showed serum cobalamin concentrations below the limit of the reference interval and 38.1% (53/139) of these were below the detectable limit for the assay. The median serum cobalamin concentration in Shar Peis was significantly lower than in other breeds. Shar Peis with gastrointestinal disease had significantly lower serum cobalamin and higher serum methylmalonic acid concentrations compared to healthy Shar Peis. Healthy Shar Peis had significantly increased serum methylmalonic acid concentrations compared to healthy dogs of other breeds. There were no meaningful differences in folate concentrations between groups. In conclusion, Shar Peis have a high prevalence of cobalamin deficiency compared to other breeds and healthy Shar Peis may have subclinical cobalamin deficiency. SN - 1532-2971 UR - https://www.unboundmedicine.com/medline/citation/21652239/Partial_characterization_of_cobalamin_deficiency_in_Chinese_Shar_Peis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-0233(11)00181-X DB - PRIME DP - Unbound Medicine ER -