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Nocturnal enuresis in patients taking clozapine, risperidone, olanzapine and quetiapine: comparative cohort study.
Br J Psychiatry. 2011 Aug; 199(2):140-4.BJ

Abstract

BACKGROUND

Nocturnal enuresis has been reported in patients taking clozapine, but the incidence has not been accurately established. The incidence of enuresis in patients taking risperidone, olanzapine or quetiapine is unknown. Aims To compare nocturnal enuresis in patients taking clozapine with that in patients taking risperidone, olanzapine or quetiapine.

METHOD

Observational cohort study using prescription event monitoring methods. Patients prescribed atypical antipsychotic medicines were followed up by questionnaires that were sent to their medical practitioner. Practitioners were asked to directly ask their patients about bed-wetting.

RESULTS

Nocturnal enuresis was reported by 17 of 82 (20.7%) patients taking clozapine, 11 of 115 (9.6%) taking olanzapine, 7 of 105 (6.7%) taking quetiapine and 12 of 195 (6.2%) taking risperidone. Compared with clozapine, the risk of nocturnal enuresis was significantly lower in patients taking olanzapine (odds ratio, OR = 0.43, 95% CI 0.19-0.96), quetiapine (OR = 0.33, 95% CI 0.13-0.59) or risperidone (OR = 0.27, 0.12-0.59), with odds ratios adjusted for age, gender and duration of treatment.

CONCLUSIONS

Approximately one in five patients prescribed clozapine experienced bed-wetting. This was significantly higher than the rate of nocturnal enuresis in patients taking olanzapine, quetiapine or risperidone.

Authors+Show Affiliations

Director, Intensive Medicines Monitoring Programme, Department of Preventive and Social Medicine, University of Otago, PO Box 913, Dunedin 9054, New Zealand. Mira.harrison-woolrych@otago.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21653944

Citation

Harrison-Woolrych, Mira, et al. "Nocturnal Enuresis in Patients Taking Clozapine, Risperidone, Olanzapine and Quetiapine: Comparative Cohort Study." The British Journal of Psychiatry : the Journal of Mental Science, vol. 199, no. 2, 2011, pp. 140-4.
Harrison-Woolrych M, Skegg K, Ashton J, et al. Nocturnal enuresis in patients taking clozapine, risperidone, olanzapine and quetiapine: comparative cohort study. Br J Psychiatry. 2011;199(2):140-4.
Harrison-Woolrych, M., Skegg, K., Ashton, J., Herbison, P., & Skegg, D. C. (2011). Nocturnal enuresis in patients taking clozapine, risperidone, olanzapine and quetiapine: comparative cohort study. The British Journal of Psychiatry : the Journal of Mental Science, 199(2), 140-4. https://doi.org/10.1192/bjp.bp.110.087478
Harrison-Woolrych M, et al. Nocturnal Enuresis in Patients Taking Clozapine, Risperidone, Olanzapine and Quetiapine: Comparative Cohort Study. Br J Psychiatry. 2011;199(2):140-4. PubMed PMID: 21653944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nocturnal enuresis in patients taking clozapine, risperidone, olanzapine and quetiapine: comparative cohort study. AU - Harrison-Woolrych,Mira, AU - Skegg,Keren, AU - Ashton,Janelle, AU - Herbison,Peter, AU - Skegg,David C G, Y1 - 2011/06/08/ PY - 2011/6/10/entrez PY - 2011/6/10/pubmed PY - 2011/10/25/medline SP - 140 EP - 4 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 199 IS - 2 N2 - BACKGROUND: Nocturnal enuresis has been reported in patients taking clozapine, but the incidence has not been accurately established. The incidence of enuresis in patients taking risperidone, olanzapine or quetiapine is unknown. Aims To compare nocturnal enuresis in patients taking clozapine with that in patients taking risperidone, olanzapine or quetiapine. METHOD: Observational cohort study using prescription event monitoring methods. Patients prescribed atypical antipsychotic medicines were followed up by questionnaires that were sent to their medical practitioner. Practitioners were asked to directly ask their patients about bed-wetting. RESULTS: Nocturnal enuresis was reported by 17 of 82 (20.7%) patients taking clozapine, 11 of 115 (9.6%) taking olanzapine, 7 of 105 (6.7%) taking quetiapine and 12 of 195 (6.2%) taking risperidone. Compared with clozapine, the risk of nocturnal enuresis was significantly lower in patients taking olanzapine (odds ratio, OR = 0.43, 95% CI 0.19-0.96), quetiapine (OR = 0.33, 95% CI 0.13-0.59) or risperidone (OR = 0.27, 0.12-0.59), with odds ratios adjusted for age, gender and duration of treatment. CONCLUSIONS: Approximately one in five patients prescribed clozapine experienced bed-wetting. This was significantly higher than the rate of nocturnal enuresis in patients taking olanzapine, quetiapine or risperidone. SN - 1472-1465 UR - https://www.unboundmedicine.com/medline/citation/21653944/Nocturnal_enuresis_in_patients_taking_clozapine_risperidone_olanzapine_and_quetiapine:_comparative_cohort_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007125000256134/type/journal_article DB - PRIME DP - Unbound Medicine ER -