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Optimal haematocrit in subjects with normal haemoglobin genotype (HbAA), sickle cell trait (HbAS), and homozygous sickle cell disease (HbSS).
Clin Hemorheol Microcirc. 2011; 47(4):253-60.CH

Abstract

The determination of an optimal haematocrit (H0) has important clinical implications if such a level can be attained, and more importantly, maintained. This is defined as a haematocrit level, above or below which oxygen delivery is deleteriously affected. This study is designed to determine an optimal haematocrit in normal (AA), sickle cell trait (AS) and sickle cell disease (SS) subjects. Twenty-seven apparently healthy subjects having normal haemoglobin genotype, 24 with sickle cell trait and 42 with homozygous sickle cell disease were recruited into the study. Whole blood viscosity (WBV) was measured by a Wells Brookfield Cone and Plate Viscometer at a shear rate of 230 sec-1. Haematocrit was determined by an AC.Tron Coulter Counter. The optimal haematocrit was calculated as the inverse of a constant, K, which was derived from the haematocrit and viscosity data. Our findings showed that the H0 varied significantly among the 3 haemoglobin genotypes, in the order AA vs SS and AS vs SS. Additionally, the data indicated an increased H0 in subjects with sickle cell trait, suggesting a possible impairment in oxygen delivery in these individuals.

Authors+Show Affiliations

Department of Basic Medical Sciences, Physiology Section, University of the West Indies, Jamaica.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21654054

Citation

Bowers, A S., et al. "Optimal Haematocrit in Subjects With Normal Haemoglobin Genotype (HbAA), Sickle Cell Trait (HbAS), and Homozygous Sickle Cell Disease (HbSS)." Clinical Hemorheology and Microcirculation, vol. 47, no. 4, 2011, pp. 253-60.
Bowers AS, Pepple DJ, Reid HL. Optimal haematocrit in subjects with normal haemoglobin genotype (HbAA), sickle cell trait (HbAS), and homozygous sickle cell disease (HbSS). Clin Hemorheol Microcirc. 2011;47(4):253-60.
Bowers, A. S., Pepple, D. J., & Reid, H. L. (2011). Optimal haematocrit in subjects with normal haemoglobin genotype (HbAA), sickle cell trait (HbAS), and homozygous sickle cell disease (HbSS). Clinical Hemorheology and Microcirculation, 47(4), 253-60. https://doi.org/10.3233/CH-2011-1387
Bowers AS, Pepple DJ, Reid HL. Optimal Haematocrit in Subjects With Normal Haemoglobin Genotype (HbAA), Sickle Cell Trait (HbAS), and Homozygous Sickle Cell Disease (HbSS). Clin Hemorheol Microcirc. 2011;47(4):253-60. PubMed PMID: 21654054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimal haematocrit in subjects with normal haemoglobin genotype (HbAA), sickle cell trait (HbAS), and homozygous sickle cell disease (HbSS). AU - Bowers,A S, AU - Pepple,D J, AU - Reid,H L, PY - 2011/6/10/entrez PY - 2011/6/10/pubmed PY - 2011/10/29/medline SP - 253 EP - 60 JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. VL - 47 IS - 4 N2 - The determination of an optimal haematocrit (H0) has important clinical implications if such a level can be attained, and more importantly, maintained. This is defined as a haematocrit level, above or below which oxygen delivery is deleteriously affected. This study is designed to determine an optimal haematocrit in normal (AA), sickle cell trait (AS) and sickle cell disease (SS) subjects. Twenty-seven apparently healthy subjects having normal haemoglobin genotype, 24 with sickle cell trait and 42 with homozygous sickle cell disease were recruited into the study. Whole blood viscosity (WBV) was measured by a Wells Brookfield Cone and Plate Viscometer at a shear rate of 230 sec-1. Haematocrit was determined by an AC.Tron Coulter Counter. The optimal haematocrit was calculated as the inverse of a constant, K, which was derived from the haematocrit and viscosity data. Our findings showed that the H0 varied significantly among the 3 haemoglobin genotypes, in the order AA vs SS and AS vs SS. Additionally, the data indicated an increased H0 in subjects with sickle cell trait, suggesting a possible impairment in oxygen delivery in these individuals. SN - 1875-8622 UR - https://www.unboundmedicine.com/medline/citation/21654054/Optimal_haematocrit_in_subjects_with_normal_haemoglobin_genotype__HbAA__sickle_cell_trait__HbAS__and_homozygous_sickle_cell_disease__HbSS__ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/CH-2011-1387 DB - PRIME DP - Unbound Medicine ER -