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Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus.
Pancreas 2011; 40(5):768-72P

Abstract

OBJECTIVES

New-onset diabetes mellitus (DM) may herald pancreatic cancer (PaC). We determined whether changes in body weight distinguished PaC-associated DM (PaCDM) from type 2 DM.

METHODS

Among Olmsted County residents, we identified 29 PaCDM and 43 type 2 DM subjects who had serial fasting blood glucose measurements, new-onset DM, and no cancer-specific symptoms at DM onset. We compared body weight (kg) and fasting blood glucose (mg/dL) at DM onset, 1 to 2 years before and at index date in the 2 groups.

RESULTS

Fasting blood glucose values were similar before and at the onset of DM. Before onset of DM, PaCDM and type 2 DM subjects had similar body weight (P = 0.80). However, at onset of DM, 59% of PaCDM subjects lost weight versus 30% of type 2 DM subjects (P = 0.02). At onset of DM, 56% of type 2 DM subjects gained weight versus 31% of PaCDM subjects (P = 0.04). By index date, PaCDM subjects lost more weight than type 2 DM subjects did (8.3 ± 8.3 vs 0.8 ± 4.8 kg, P < 0.01).

CONCLUSIONS

Although new-onset primary type 2 DM is typically associated with weight gain, weight loss frequently precedes onset of PaCDM. The paradoxical development of diabetes in the face of ongoing weight loss may be an important clue to understanding the pathogenesis of PaCDM.

Authors+Show Affiliations

Department of Internal Medicine, Mayo Clinic, Rochester, MN55905, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21654538

Citation

Hart, Phil A., et al. "Weight Loss Precedes Cancer-specific Symptoms in Pancreatic Cancer-associated Diabetes Mellitus." Pancreas, vol. 40, no. 5, 2011, pp. 768-72.
Hart PA, Kamada P, Rabe KG, et al. Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus. Pancreas. 2011;40(5):768-72.
Hart, P. A., Kamada, P., Rabe, K. G., Srinivasan, S., Basu, A., Aggarwal, G., & Chari, S. T. (2011). Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus. Pancreas, 40(5), pp. 768-72. doi:10.1097/MPA.0b013e318220816a.
Hart PA, et al. Weight Loss Precedes Cancer-specific Symptoms in Pancreatic Cancer-associated Diabetes Mellitus. Pancreas. 2011;40(5):768-72. PubMed PMID: 21654538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus. AU - Hart,Phil A, AU - Kamada,Pratima, AU - Rabe,Kari G, AU - Srinivasan,Sunil, AU - Basu,Ananda, AU - Aggarwal,Gaurav, AU - Chari,Suresh T, PY - 2011/6/10/entrez PY - 2011/6/10/pubmed PY - 2011/10/25/medline SP - 768 EP - 72 JF - Pancreas JO - Pancreas VL - 40 IS - 5 N2 - OBJECTIVES: New-onset diabetes mellitus (DM) may herald pancreatic cancer (PaC). We determined whether changes in body weight distinguished PaC-associated DM (PaCDM) from type 2 DM. METHODS: Among Olmsted County residents, we identified 29 PaCDM and 43 type 2 DM subjects who had serial fasting blood glucose measurements, new-onset DM, and no cancer-specific symptoms at DM onset. We compared body weight (kg) and fasting blood glucose (mg/dL) at DM onset, 1 to 2 years before and at index date in the 2 groups. RESULTS: Fasting blood glucose values were similar before and at the onset of DM. Before onset of DM, PaCDM and type 2 DM subjects had similar body weight (P = 0.80). However, at onset of DM, 59% of PaCDM subjects lost weight versus 30% of type 2 DM subjects (P = 0.02). At onset of DM, 56% of type 2 DM subjects gained weight versus 31% of PaCDM subjects (P = 0.04). By index date, PaCDM subjects lost more weight than type 2 DM subjects did (8.3 ± 8.3 vs 0.8 ± 4.8 kg, P < 0.01). CONCLUSIONS: Although new-onset primary type 2 DM is typically associated with weight gain, weight loss frequently precedes onset of PaCDM. The paradoxical development of diabetes in the face of ongoing weight loss may be an important clue to understanding the pathogenesis of PaCDM. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/21654538/Weight_loss_precedes_cancer_specific_symptoms_in_pancreatic_cancer_associated_diabetes_mellitus_ L2 - http://Insights.ovid.com/pubmed?pmid=21654538 DB - PRIME DP - Unbound Medicine ER -