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Folic acid in pregnancy - is there a link with childhood asthma or wheeze?
Aust Fam Physician. 2011 Jun; 40(6):421-4.AF

Abstract

BACKGROUND

Folic acid supplementation has an established role in early pregnancy for preventing neural tube defects. However, there is controversy over a possible link between late pregnancy folic acid supplementation and childhood asthma.

OBJECTIVE

To review the evidence exploring the association between maternal folate exposure in pregnancy and childhood asthma or wheeze.

RESULTS

Four relevant observational studies were identified. Two found statistically significant associations between childhood asthma and late (but not early) pregnancy maternal folic acid exposure. Another found a statistically significant association between childhood wheeze and early (but not late) pregnancy maternal folic acid exposure. A fourth study found little association between maternal dietary folate in pregnancy and infantile wheeze.

DISCUSSION

The currently available evidence regarding an association between folate in pregnancy and childhood asthma or wheeze is conflicting. We offer suggestions for discussing the potential risk with patients and recommend further research on this subject be conducted.

Authors+Show Affiliations

Discipline of General Practice, School of Primary, Aboriginal and Rural Health Care, University of Western Australia, Perth, Australia. aesharland@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21655492

Citation

Sharland, Eleanor, et al. "Folic Acid in Pregnancy - Is There a Link With Childhood Asthma or Wheeze?" Australian Family Physician, vol. 40, no. 6, 2011, pp. 421-4.
Sharland E, Montgomery B, Granell R. Folic acid in pregnancy - is there a link with childhood asthma or wheeze? Aust Fam Physician. 2011;40(6):421-4.
Sharland, E., Montgomery, B., & Granell, R. (2011). Folic acid in pregnancy - is there a link with childhood asthma or wheeze? Australian Family Physician, 40(6), 421-4.
Sharland E, Montgomery B, Granell R. Folic Acid in Pregnancy - Is There a Link With Childhood Asthma or Wheeze. Aust Fam Physician. 2011;40(6):421-4. PubMed PMID: 21655492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid in pregnancy - is there a link with childhood asthma or wheeze? AU - Sharland,Eleanor, AU - Montgomery,Brett, AU - Granell,Raquel, PY - 2011/6/10/entrez PY - 2011/6/10/pubmed PY - 2012/1/6/medline SP - 421 EP - 4 JF - Australian family physician JO - Aust Fam Physician VL - 40 IS - 6 N2 - BACKGROUND: Folic acid supplementation has an established role in early pregnancy for preventing neural tube defects. However, there is controversy over a possible link between late pregnancy folic acid supplementation and childhood asthma. OBJECTIVE: To review the evidence exploring the association between maternal folate exposure in pregnancy and childhood asthma or wheeze. RESULTS: Four relevant observational studies were identified. Two found statistically significant associations between childhood asthma and late (but not early) pregnancy maternal folic acid exposure. Another found a statistically significant association between childhood wheeze and early (but not late) pregnancy maternal folic acid exposure. A fourth study found little association between maternal dietary folate in pregnancy and infantile wheeze. DISCUSSION: The currently available evidence regarding an association between folate in pregnancy and childhood asthma or wheeze is conflicting. We offer suggestions for discussing the potential risk with patients and recommend further research on this subject be conducted. SN - 0300-8495 UR - https://www.unboundmedicine.com/medline/citation/21655492/Folic_acid_in_pregnancy___is_there_a_link_with_childhood_asthma_or_wheeze L2 - http://www.racgp.org.au/afp/201106/42664 DB - PRIME DP - Unbound Medicine ER -