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The most important metabolic risk factors in recurrent urinary stone formers.
Urol J 2011; 8(2):99-106UJ

Abstract

PURPOSE

To evaluate different urinary factors contributing to idiopathic calcium stone disease for determining appropriate medical treatments.

MATERIALS AND METHODS

Two 24-hour urine samples were collected from 106 male recurrent idiopathic calcium stone formers and another 109 randomly selected men as the control group matching for age.

RESULTS

Cases had significantly higher mean urine oxalate, calcium, uric acid, and chloride in comparison with the healthy controls (P < .001). After necessary adjustment, only mean urine levels of oxalate and uric acid were higher in stone formers than those in controls. The mean value of supersaturation for calcium oxalate was significantly higher in patients than the controls (P = .001); whereas supersaturation for calcium phosphate and uric acid did not reach statistical significance (P = .675 and P = .675, respectively). Hyperoxaluria and hypercalciuria were among the most frequent abnormalities. After categorizing urine parameter values into four quartiles, the risk of stone formation was found to increase as the urine calcium, oxalate, uric acid, chloride, and citrate rise. In contrast, the risk of stone formation decreased with the increase of urine potassium.

CONCLUSION

Oxalate seems to play the most important role as urinary stone risk factor in our population followed by calcium and uric acid. In addition to the risk factors, it seems that supersaturation as the sum of all risk factors probably has a high predictive value.

Authors+Show Affiliations

Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21656467

Citation

Parvin, Mahmoud, et al. "The Most Important Metabolic Risk Factors in Recurrent Urinary Stone Formers." Urology Journal, vol. 8, no. 2, 2011, pp. 99-106.
Parvin M, Shakhssalim N, Basiri A, et al. The most important metabolic risk factors in recurrent urinary stone formers. Urol J. 2011;8(2):99-106.
Parvin, M., Shakhssalim, N., Basiri, A., Miladipour, A. H., Golestan, B., Mohammadi Torbati, P., ... Eftekhari, S. (2011). The most important metabolic risk factors in recurrent urinary stone formers. Urology Journal, 8(2), pp. 99-106.
Parvin M, et al. The Most Important Metabolic Risk Factors in Recurrent Urinary Stone Formers. Urol J. 2011;8(2):99-106. PubMed PMID: 21656467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The most important metabolic risk factors in recurrent urinary stone formers. AU - Parvin,Mahmoud, AU - Shakhssalim,Nasser, AU - Basiri,Abbas, AU - Miladipour,Amir Hossein, AU - Golestan,Banafsheh, AU - Mohammadi Torbati,Peyman, AU - Azadvari,Mohaddeseh, AU - Eftekhari,Sanaz, PY - 2011/6/10/entrez PY - 2011/6/10/pubmed PY - 2011/10/19/medline SP - 99 EP - 106 JF - Urology journal JO - Urol J VL - 8 IS - 2 N2 - PURPOSE: To evaluate different urinary factors contributing to idiopathic calcium stone disease for determining appropriate medical treatments. MATERIALS AND METHODS: Two 24-hour urine samples were collected from 106 male recurrent idiopathic calcium stone formers and another 109 randomly selected men as the control group matching for age. RESULTS: Cases had significantly higher mean urine oxalate, calcium, uric acid, and chloride in comparison with the healthy controls (P < .001). After necessary adjustment, only mean urine levels of oxalate and uric acid were higher in stone formers than those in controls. The mean value of supersaturation for calcium oxalate was significantly higher in patients than the controls (P = .001); whereas supersaturation for calcium phosphate and uric acid did not reach statistical significance (P = .675 and P = .675, respectively). Hyperoxaluria and hypercalciuria were among the most frequent abnormalities. After categorizing urine parameter values into four quartiles, the risk of stone formation was found to increase as the urine calcium, oxalate, uric acid, chloride, and citrate rise. In contrast, the risk of stone formation decreased with the increase of urine potassium. CONCLUSION: Oxalate seems to play the most important role as urinary stone risk factor in our population followed by calcium and uric acid. In addition to the risk factors, it seems that supersaturation as the sum of all risk factors probably has a high predictive value. SN - 1735-546X UR - https://www.unboundmedicine.com/medline/citation/21656467/The_most_important_metabolic_risk_factors_in_recurrent_urinary_stone_formers_ L2 - http://journals.sbmu.ac.ir/urolj/index.php/uj/article/view/1019/545 DB - PRIME DP - Unbound Medicine ER -