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Hypothalamic-pituitary and thyroid function in chronic alcoholics with neurological complications.
Alcohol Clin Exp Res. 1990 Jun; 14(3):363-7.AC

Abstract

Endocrinological tests were performed in 14 chronic alcoholic men with signs of intellectual impairment and/or peripheral neuropathy. All had been abstinent from alcohol for at least 1 month. Basal serum growth hormone (GH) was consistently increased in only one patient whereas the GH responses to insulin hypoglycemia stimulation was normal in all patients. Thyroid function values (T4, T3, rT3, TSH) were normal in all patients whereas baseline serum prolactin values were significantly increased in alcoholics as compared with a control group. In a combined TRH- and GnRH-stimulation tests, GH-responses were also normal whereas TSH and prolactin responses were blunted or absent in about half of the patients, the responses correlating significantly (p less than 0.01). It is concluded that disturbances in the hypothalamic-pituitary axis may occur in chronic alcoholics with nervous impairment independently of the physical deterioration, which often is associated with chronic alcoholism.

Authors+Show Affiliations

Department of Neurology, Rigshospitalet, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2165749

Citation

Knudsen, G M., et al. "Hypothalamic-pituitary and Thyroid Function in Chronic Alcoholics With Neurological Complications." Alcoholism, Clinical and Experimental Research, vol. 14, no. 3, 1990, pp. 363-7.
Knudsen GM, Christensen H, Berild D, et al. Hypothalamic-pituitary and thyroid function in chronic alcoholics with neurological complications. Alcohol Clin Exp Res. 1990;14(3):363-7.
Knudsen, G. M., Christensen, H., Berild, D., Melgaard, B., Kirkegaard, C., & Hasselbalch, H. (1990). Hypothalamic-pituitary and thyroid function in chronic alcoholics with neurological complications. Alcoholism, Clinical and Experimental Research, 14(3), 363-7.
Knudsen GM, et al. Hypothalamic-pituitary and Thyroid Function in Chronic Alcoholics With Neurological Complications. Alcohol Clin Exp Res. 1990;14(3):363-7. PubMed PMID: 2165749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypothalamic-pituitary and thyroid function in chronic alcoholics with neurological complications. AU - Knudsen,G M, AU - Christensen,H, AU - Berild,D, AU - Melgaard,B, AU - Kirkegaard,C, AU - Hasselbalch,H, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 363 EP - 7 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 14 IS - 3 N2 - Endocrinological tests were performed in 14 chronic alcoholic men with signs of intellectual impairment and/or peripheral neuropathy. All had been abstinent from alcohol for at least 1 month. Basal serum growth hormone (GH) was consistently increased in only one patient whereas the GH responses to insulin hypoglycemia stimulation was normal in all patients. Thyroid function values (T4, T3, rT3, TSH) were normal in all patients whereas baseline serum prolactin values were significantly increased in alcoholics as compared with a control group. In a combined TRH- and GnRH-stimulation tests, GH-responses were also normal whereas TSH and prolactin responses were blunted or absent in about half of the patients, the responses correlating significantly (p less than 0.01). It is concluded that disturbances in the hypothalamic-pituitary axis may occur in chronic alcoholics with nervous impairment independently of the physical deterioration, which often is associated with chronic alcoholism. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/2165749/Hypothalamic_pituitary_and_thyroid_function_in_chronic_alcoholics_with_neurological_complications_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=1990&volume=14&issue=3&spage=363 DB - PRIME DP - Unbound Medicine ER -