Tags

Type your tag names separated by a space and hit enter

Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats.
J Ethnopharmacol. 2011 Sep 01; 137(1):341-4.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Argyreia speciosa (L.f), Sweet (Family Convolvulaceae) is used traditionally in Indian System of Medicine as aphrodisiac, rejuvenating agent, intellect promoting agent, brain tonic and in the therapy of hepatomegaly, diabetes and chronic ulcer.

AIM OF THE STUDY

To study the gastroprotective effect of standardized butanol fraction of Argyreia speciosa leaf (ASE).

MATERIALS AND METHODS

The butanol fraction of Argyreia speciosa leaf (ASE; 50, 100 and 200mg/kg body weight) was administered orally, twice daily for 5 days for prevention from Aspirin (ASP)-, ethanol (EtOH)-, cold-restraint stress (CRS) - and pylorus ligation (PL)-induced ulcers. Estimation of antioxidant enzymes activity was carried out in CRS-induced ulcer model, and various gastric secretion parameters like volume of gastric juice, acid output, and pH value were estimated in PL-induced ulcer model.

RESULT

ASE showed dose-dependent ulcer protective effect in ASP 23.64-58.76% (p<0.01 to p<0.001), EtOH 15.45-58.45% (p<0.001), CRS 19.39-78.36% (p<0.001) and PL 19.67-69.04% (p<0.05 to p<0.01), respectively. The percentage of protection by standard drug ranitidine was 77.77-84.32% (p<0.01 to p<0.001) in various gastric ulcer models. The gastric wall mucus was significantly (p<0.001) enhanced by ASE and is regarded as the first line of defence against EtOH-induced gastric ulcers showing cytoprotective property. ASE showed a marginal decrease in volume, acid pepsin concentration and acid pepsin output. However, ASE reduced the ulcer index with significant decrease in LPO level (p<0.001), and SOD level (p<0.01 to p<0.001) as compared with CRS-induced group. A gradual and significant increase in CAT values were observed at 100 and 200mg/kg dose levels (p<0.01 to p<0.001).

CONCLUSIONS

The results of our study revealed that Argyreia speciosa possess significant dose dependent gastroprotective activity, probably due to its free radical scavenging activity.

Links

Publisher Full Text

Authors+Show Affiliations

Jaiswal SK
Pharmacognosy & Ethnopharmacology Div., National Botanical Research Institute (CSIR), Rana Pratap Marg, P.O. Box 436, Lucknow 226001, Uttar Pradesh, India.
Rao CV
No affiliation info available
Sharma B
No affiliation info available
Mishra P
No affiliation info available
Das S
No affiliation info available
Dubey MK
No affiliation info available

MeSH

AnimalsAnti-Ulcer AgentsAspirinButanolsCatalaseConvolvulaceaeCytoprotectionDisease Models, AnimalDose-Response Relationship, DrugEthanolFree Radical ScavengersGastric JuiceGastric MucosaHumansHydrogen-Ion ConcentrationLipid PeroxidationMaleMiceMucusPlant ExtractsPlant LeavesRanitidineRatsRats, Sprague-DawleySolventsStomach UlcerSuperoxide Dismutase

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21658440

Citation

Jaiswal, Sunil K., et al. "Gastroprotective Effect of Standardized Leaf Extract From Argyreia Speciosa On Experimental Gastric Ulcers in Rats." Journal of Ethnopharmacology, vol. 137, no. 1, 2011, pp. 341-4.
Jaiswal SK, Rao CV, Sharma B, et al. Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats. J Ethnopharmacol. 2011;137(1):341-4.
Jaiswal, S. K., Rao, C. V., Sharma, B., Mishra, P., Das, S., & Dubey, M. K. (2011). Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats. Journal of Ethnopharmacology, 137(1), 341-4. https://doi.org/10.1016/j.jep.2011.05.028
Jaiswal SK, et al. Gastroprotective Effect of Standardized Leaf Extract From Argyreia Speciosa On Experimental Gastric Ulcers in Rats. J Ethnopharmacol. 2011 Sep 1;137(1):341-4. PubMed PMID: 21658440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats. AU - Jaiswal,Sunil K, AU - Rao,Chandana V, AU - Sharma,Brijesh, AU - Mishra,Pritee, AU - Das,Sanjib, AU - Dubey,Mukesh K, Y1 - 2011/05/31/ PY - 2010/07/13/received PY - 2011/04/28/revised PY - 2011/05/25/accepted PY - 2011/6/11/entrez PY - 2011/6/11/pubmed PY - 2011/12/28/medline SP - 341 EP - 4 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Argyreia speciosa (L.f), Sweet (Family Convolvulaceae) is used traditionally in Indian System of Medicine as aphrodisiac, rejuvenating agent, intellect promoting agent, brain tonic and in the therapy of hepatomegaly, diabetes and chronic ulcer. AIM OF THE STUDY: To study the gastroprotective effect of standardized butanol fraction of Argyreia speciosa leaf (ASE). MATERIALS AND METHODS: The butanol fraction of Argyreia speciosa leaf (ASE; 50, 100 and 200mg/kg body weight) was administered orally, twice daily for 5 days for prevention from Aspirin (ASP)-, ethanol (EtOH)-, cold-restraint stress (CRS) - and pylorus ligation (PL)-induced ulcers. Estimation of antioxidant enzymes activity was carried out in CRS-induced ulcer model, and various gastric secretion parameters like volume of gastric juice, acid output, and pH value were estimated in PL-induced ulcer model. RESULT: ASE showed dose-dependent ulcer protective effect in ASP 23.64-58.76% (p<0.01 to p<0.001), EtOH 15.45-58.45% (p<0.001), CRS 19.39-78.36% (p<0.001) and PL 19.67-69.04% (p<0.05 to p<0.01), respectively. The percentage of protection by standard drug ranitidine was 77.77-84.32% (p<0.01 to p<0.001) in various gastric ulcer models. The gastric wall mucus was significantly (p<0.001) enhanced by ASE and is regarded as the first line of defence against EtOH-induced gastric ulcers showing cytoprotective property. ASE showed a marginal decrease in volume, acid pepsin concentration and acid pepsin output. However, ASE reduced the ulcer index with significant decrease in LPO level (p<0.001), and SOD level (p<0.01 to p<0.001) as compared with CRS-induced group. A gradual and significant increase in CAT values were observed at 100 and 200mg/kg dose levels (p<0.01 to p<0.001). CONCLUSIONS: The results of our study revealed that Argyreia speciosa possess significant dose dependent gastroprotective activity, probably due to its free radical scavenging activity. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21658440/Gastroprotective_effect_of_standardized_leaf_extract_from_Argyreia_speciosa_on_experimental_gastric_ulcers_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00393-X DB - PRIME DP - Unbound Medicine ER -