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Sex differences in the electrophysiological characteristics of pulmonary veins and left atrium and their clinical implication in atrial fibrillation.
Circ Arrhythm Electrophysiol. 2011 Aug; 4(4):550-9.CA

Abstract

BACKGROUND

Sex and the autonomic nervous system play critical roles in the pathophysiology of atrial fibrillation (AF). Sex differences in electrophysiological characteristics of the pulmonary veins (PVs, AF initiator) and left atrium (LA, AF substrate) are not clear.

METHODS AND RESULTS

Conventional microelectrodes were used to record the action potential in isolated PV and LA tissue preparations from male and female (age, 8≈10 months) rabbits before and after drug administration (adenosine, acetylcholine, and isoproterenol). Male PVs (n = 7) had a higher spontaneous beating rate (1.7 ± 0.2 versus 1.2 ± 0.1 Hz, P = 0.021) and incidence of burst firing (72% versus 11%, P = 0.038) than female PVs (n = 9). Male PVs without spontaneous activity (n = 10) and the LA (n = 11) had longer action potential durations than female PVs (n = 9) and LA (n = 9). Additionally, male PVs had a more-positive resting membrane potential (79 ± 3 versus 84±2 mV, P=0.022). Isoproterenol (3 μmol/L) increased the delayed afterdepolarizations to a greater extent in male than in female PVs. In PVs without spontaneous activity or LA, isoproterenol (0.1 and 3 μmol/L) consistently shortened the action potential durations in females but not in males. Acetylcholine (5.5 μmol/L) decreased the spontaneous activity of PVs and shortened the action potential durations in both groups. Adenosine (10 μmol/L) also similarly decreased the spontaneous activity of PVs and delayed afterdepolarizations in both groups.

CONCLUSIONS

There are significant sex differences in PV and LA action potential characteristics in rabbits. The higher amplitude of delayed afterdepolarizations after isoproterenol superfusion in male PVs may contribute to sex-related arrhythmogenesis.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Tsai WC
Division of Cardiology, Tzu-Chi General Hospital, Hualien, Taipei, Taiwan.
Chen YC
No affiliation info available
Lin YK
No affiliation info available
Chen SA
No affiliation info available
Chen YJ
No affiliation info available

MeSH

AcetylcholineAction PotentialsAdenosineAnimalsAtrial FibrillationAutonomic Nervous SystemCardiotonic AgentsDisease Models, AnimalElectrophysiologic Techniques, CardiacFemaleHeart AtriaIsoproterenolMalePulmonary VeinsRabbitsSex CharacteristicsVasodilator Agents

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21659634

Citation

Tsai, Wen-Chin, et al. "Sex Differences in the Electrophysiological Characteristics of Pulmonary Veins and Left Atrium and Their Clinical Implication in Atrial Fibrillation." Circulation. Arrhythmia and Electrophysiology, vol. 4, no. 4, 2011, pp. 550-9.
Tsai WC, Chen YC, Lin YK, et al. Sex differences in the electrophysiological characteristics of pulmonary veins and left atrium and their clinical implication in atrial fibrillation. Circ Arrhythm Electrophysiol. 2011;4(4):550-9.
Tsai, W. C., Chen, Y. C., Lin, Y. K., Chen, S. A., & Chen, Y. J. (2011). Sex differences in the electrophysiological characteristics of pulmonary veins and left atrium and their clinical implication in atrial fibrillation. Circulation. Arrhythmia and Electrophysiology, 4(4), 550-9. https://doi.org/10.1161/CIRCEP.111.961995
Tsai WC, et al. Sex Differences in the Electrophysiological Characteristics of Pulmonary Veins and Left Atrium and Their Clinical Implication in Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2011;4(4):550-9. PubMed PMID: 21659634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex differences in the electrophysiological characteristics of pulmonary veins and left atrium and their clinical implication in atrial fibrillation. AU - Tsai,Wen-Chin, AU - Chen,Yao-Chang, AU - Lin,Yung-Kuo, AU - Chen,Shih-Ann, AU - Chen,Yi-Jen, Y1 - 2011/06/09/ PY - 2011/6/11/entrez PY - 2011/6/11/pubmed PY - 2011/10/14/medline SP - 550 EP - 9 JF - Circulation. Arrhythmia and electrophysiology JO - Circ Arrhythm Electrophysiol VL - 4 IS - 4 N2 - BACKGROUND: Sex and the autonomic nervous system play critical roles in the pathophysiology of atrial fibrillation (AF). Sex differences in electrophysiological characteristics of the pulmonary veins (PVs, AF initiator) and left atrium (LA, AF substrate) are not clear. METHODS AND RESULTS: Conventional microelectrodes were used to record the action potential in isolated PV and LA tissue preparations from male and female (age, 8≈10 months) rabbits before and after drug administration (adenosine, acetylcholine, and isoproterenol). Male PVs (n = 7) had a higher spontaneous beating rate (1.7 ± 0.2 versus 1.2 ± 0.1 Hz, P = 0.021) and incidence of burst firing (72% versus 11%, P = 0.038) than female PVs (n = 9). Male PVs without spontaneous activity (n = 10) and the LA (n = 11) had longer action potential durations than female PVs (n = 9) and LA (n = 9). Additionally, male PVs had a more-positive resting membrane potential (79 ± 3 versus 84±2 mV, P=0.022). Isoproterenol (3 μmol/L) increased the delayed afterdepolarizations to a greater extent in male than in female PVs. In PVs without spontaneous activity or LA, isoproterenol (0.1 and 3 μmol/L) consistently shortened the action potential durations in females but not in males. Acetylcholine (5.5 μmol/L) decreased the spontaneous activity of PVs and shortened the action potential durations in both groups. Adenosine (10 μmol/L) also similarly decreased the spontaneous activity of PVs and delayed afterdepolarizations in both groups. CONCLUSIONS: There are significant sex differences in PV and LA action potential characteristics in rabbits. The higher amplitude of delayed afterdepolarizations after isoproterenol superfusion in male PVs may contribute to sex-related arrhythmogenesis. SN - 1941-3084 UR - https://www.unboundmedicine.com/medline/citation/21659634/Sex_differences_in_the_electrophysiological_characteristics_of_pulmonary_veins_and_left_atrium_and_their_clinical_implication_in_atrial_fibrillation_ DB - PRIME DP - Unbound Medicine ER -