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Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy.
Int J Radiat Oncol Biol Phys 2012; 82(4):1509-14IJ

Abstract

PURPOSE

To evaluate the long-term treatment outcome and disease behavior of primary ocular adnexal MALT (mucosa-associated lymphoid tissue) lymphoma (POAML) after treatment with radiotherapy.

METHODS AND MATERIALS

Seventy-eight patients (42 male, 36 female) diagnosed with stage I POAML between 1991 and 2010 at Kobe University Hospital were included. The median age was 60 years (range, 22-85 years). The median radiation dose administered was 30.6 Gy. Rituximab-based targeted therapy and/or chemotherapy was performed in 20 patients (25.6%). Local control (LC), recurrence-free survival (RFS), and overall survival (OS) rates were calculated using the Kaplan-Meier method.

RESULTS

The median follow-up duration was 66 months. Major tumor sites were conjunctiva in 37 patients (47.4%), orbita in 29 (37.2%), and lacrimal glands in 12 (15.4%). The 5- and 10-year OS rates were 98.1% and 95.3%, respectively. The 5- and 10-year LC rates were both 100%, and the 5- and 10-year RFS rates were 88.5% and 75.9%, respectively. Patients treated with a combination of radiotherapy and targeted therapy and/or chemotherapy had a trend for a better RFS compared with those treated with radiotherapy alone (p = 0.114). None developed greater than Grade 2 acute morbidity. There were 14 patients who experienced Grade 2 morbidities (cataract: 14; retinal disorders: 7; dry eye: 3), 23 patients who had Grade 3 morbidities (cataract: 23; dry eye: 1), and 1 patient who had Grade 4 glaucoma.

CONCLUSIONS

Radiotherapy for POAML was shown to be highly effective and safe for LC and OS on the basis of long-term observation. The absence of systemic relapse in patients with combined-modality treatment suggests that lower doses of radiation combined with targeted therapy may be worth further study.

Authors+Show Affiliations

Division of Radiation Oncology, Kobe University Graduate School of Medicine, Hyogo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21664061

Citation

Hashimoto, Naoki, et al. "Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma Treated With Radiotherapy." International Journal of Radiation Oncology, Biology, Physics, vol. 82, no. 4, 2012, pp. 1509-14.
Hashimoto N, Sasaki R, Nishimura H, et al. Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2012;82(4):1509-14.
Hashimoto, N., Sasaki, R., Nishimura, H., Yoshida, K., Miyawaki, D., Nakayama, M., ... Sugimura, K. (2012). Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 82(4), pp. 1509-14. doi:10.1016/j.ijrobp.2011.04.052.
Hashimoto N, et al. Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma Treated With Radiotherapy. Int J Radiat Oncol Biol Phys. 2012 Mar 15;82(4):1509-14. PubMed PMID: 21664061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy. AU - Hashimoto,Naoki, AU - Sasaki,Ryohei, AU - Nishimura,Hideki, AU - Yoshida,Kenji, AU - Miyawaki,Daisuke, AU - Nakayama,Masao, AU - Uehara,Kazuyuki, AU - Okamoto,Yoshiaki, AU - Ejima,Yasuo, AU - Azumi,Atsushi, AU - Matsui,Toshimitsu, AU - Sugimura,Kazuro, Y1 - 2011/06/12/ PY - 2011/02/09/received PY - 2011/04/14/revised PY - 2011/04/19/accepted PY - 2011/6/14/entrez PY - 2011/6/15/pubmed PY - 2012/4/25/medline SP - 1509 EP - 14 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 82 IS - 4 N2 - PURPOSE: To evaluate the long-term treatment outcome and disease behavior of primary ocular adnexal MALT (mucosa-associated lymphoid tissue) lymphoma (POAML) after treatment with radiotherapy. METHODS AND MATERIALS: Seventy-eight patients (42 male, 36 female) diagnosed with stage I POAML between 1991 and 2010 at Kobe University Hospital were included. The median age was 60 years (range, 22-85 years). The median radiation dose administered was 30.6 Gy. Rituximab-based targeted therapy and/or chemotherapy was performed in 20 patients (25.6%). Local control (LC), recurrence-free survival (RFS), and overall survival (OS) rates were calculated using the Kaplan-Meier method. RESULTS: The median follow-up duration was 66 months. Major tumor sites were conjunctiva in 37 patients (47.4%), orbita in 29 (37.2%), and lacrimal glands in 12 (15.4%). The 5- and 10-year OS rates were 98.1% and 95.3%, respectively. The 5- and 10-year LC rates were both 100%, and the 5- and 10-year RFS rates were 88.5% and 75.9%, respectively. Patients treated with a combination of radiotherapy and targeted therapy and/or chemotherapy had a trend for a better RFS compared with those treated with radiotherapy alone (p = 0.114). None developed greater than Grade 2 acute morbidity. There were 14 patients who experienced Grade 2 morbidities (cataract: 14; retinal disorders: 7; dry eye: 3), 23 patients who had Grade 3 morbidities (cataract: 23; dry eye: 1), and 1 patient who had Grade 4 glaucoma. CONCLUSIONS: Radiotherapy for POAML was shown to be highly effective and safe for LC and OS on the basis of long-term observation. The absence of systemic relapse in patients with combined-modality treatment suggests that lower doses of radiation combined with targeted therapy may be worth further study. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/21664061/Long_term_outcome_and_patterns_of_failure_in_primary_ocular_adnexal_mucosa_associated_lymphoid_tissue_lymphoma_treated_with_radiotherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(11)00573-6 DB - PRIME DP - Unbound Medicine ER -