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Cutting edge assessment of the impact of autoimmunity on female reproductive success.

Abstract

There, likely, is no more controversial issue in reproductive medicine than the effects of autoimmunity on female reproductive success. Published studies are, therefore, often biased. We performed PubMed, Google Scholar and Medline searches for the years 2000-2010 under various key words and phrases, referring to effects of autoimmunity/autoimmune diseases on pregnancy/pregnancy outcomes/pregnancy rates/reproduction/reproductive outcomes/fertility/infertility/fertility treatments/infertility treatments, and a number of similar terms. Reference lists of selected manuscripts were evaluated for additional, potential references. All selected manuscripts were reviewed by at least one author (N.G.). Opinions were reached based on preferential review of only selected studies, which offered data, primarily developed in pursuit of unrelated scientific questions. Data from various medical fields point, surprisingly effectively, toward significant impacts of autoimmunity on female reproductive success. Autoimmunity not only increases miscarriage risks but also reduces female fecundity and infertility treatment success. A, likely, reason why differences of opinion have persisted is that effects are primarily observed in genetically predisposed women, with specific fragile X mental retardation 1 (FMR1) genotypes. This discovery coincides with recently increasing appreciation of the importance of the long arm of the X chromosome (Xq) in control of functional ovarian reserve (reflective of female fertility) and autoimmunity, with FMR1at Xq27.3, located at cross roads of both. Autoimmune effects on female reproductive success deserve recognition. Further investigations must not ignore patient stratification, based on ovarian FMR1 genotypes. Genetic definition of high-risk patients should lead to development of successful therapeutic interventions.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    The Center for Human Reproduction, New York, NY 10021, USA. ngleicher@thechr.com

    ,

    Source

    Journal of autoimmunity 38:2-3 2012 May pg J74-80

    MeSH

    Aneuploidy
    Autoimmunity
    Chromosomes, Human, X
    Female
    Fragile X Mental Retardation Protein
    Humans
    Immune Tolerance
    Infertility
    Pregnancy
    Prevalence
    Reproduction

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    21664106

    Citation

    Gleicher, Norbert, et al. "Cutting Edge Assessment of the Impact of Autoimmunity On Female Reproductive Success." Journal of Autoimmunity, vol. 38, no. 2-3, 2012, pp. J74-80.
    Gleicher N, Weghofer A, Barad DH. Cutting edge assessment of the impact of autoimmunity on female reproductive success. J Autoimmun. 2012;38(2-3):J74-80.
    Gleicher, N., Weghofer, A., & Barad, D. H. (2012). Cutting edge assessment of the impact of autoimmunity on female reproductive success. Journal of Autoimmunity, 38(2-3), pp. J74-80. doi:10.1016/j.jaut.2011.05.016.
    Gleicher N, Weghofer A, Barad DH. Cutting Edge Assessment of the Impact of Autoimmunity On Female Reproductive Success. J Autoimmun. 2012;38(2-3):J74-80. PubMed PMID: 21664106.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cutting edge assessment of the impact of autoimmunity on female reproductive success. AU - Gleicher,Norbert, AU - Weghofer,Andrea, AU - Barad,David H, Y1 - 2011/06/12/ PY - 2011/01/28/received PY - 2011/05/13/revised PY - 2011/05/18/accepted PY - 2011/6/14/entrez PY - 2011/6/15/pubmed PY - 2012/7/18/medline SP - J74 EP - 80 JF - Journal of autoimmunity JO - J. Autoimmun. VL - 38 IS - 2-3 N2 - There, likely, is no more controversial issue in reproductive medicine than the effects of autoimmunity on female reproductive success. Published studies are, therefore, often biased. We performed PubMed, Google Scholar and Medline searches for the years 2000-2010 under various key words and phrases, referring to effects of autoimmunity/autoimmune diseases on pregnancy/pregnancy outcomes/pregnancy rates/reproduction/reproductive outcomes/fertility/infertility/fertility treatments/infertility treatments, and a number of similar terms. Reference lists of selected manuscripts were evaluated for additional, potential references. All selected manuscripts were reviewed by at least one author (N.G.). Opinions were reached based on preferential review of only selected studies, which offered data, primarily developed in pursuit of unrelated scientific questions. Data from various medical fields point, surprisingly effectively, toward significant impacts of autoimmunity on female reproductive success. Autoimmunity not only increases miscarriage risks but also reduces female fecundity and infertility treatment success. A, likely, reason why differences of opinion have persisted is that effects are primarily observed in genetically predisposed women, with specific fragile X mental retardation 1 (FMR1) genotypes. This discovery coincides with recently increasing appreciation of the importance of the long arm of the X chromosome (Xq) in control of functional ovarian reserve (reflective of female fertility) and autoimmunity, with FMR1at Xq27.3, located at cross roads of both. Autoimmune effects on female reproductive success deserve recognition. Further investigations must not ignore patient stratification, based on ovarian FMR1 genotypes. Genetic definition of high-risk patients should lead to development of successful therapeutic interventions. SN - 1095-9157 UR - https://www.unboundmedicine.com/medline/citation/21664106/full_citation/Cutting_edge_assessment_of_the_impact_of_autoimmunity_on_female_reproductive_success_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-8411(11)00058-8 DB - PRIME DP - Unbound Medicine ER -