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Improving working memory: exploring the effect of transcranial random noise stimulation and transcranial direct current stimulation on the dorsolateral prefrontal cortex.
Clin Neurophysiol. 2011 Dec; 122(12):2384-9.CN

Abstract

OBJECTIVE

The aim of this study was to determine if working memory (WM) performance is significantly improved after the delivery of transcranial random noise stimulation (tRNS) to the left dorsolateral prefrontal cortex (DLPFC), compared to an active comparator or sham.

METHODS

Ten participants undertook three experimental sessions in which they received 10 min of anodal tDCS (active comparator), tRNS or sham tDCS whilst performing the Sternberg WM task. Intra-stimulation engagement in a WM task was undertaken as this has been previously shown to enhance the effects of tDCS. Experimental sessions were separated by a minimum of 1 week. Immediately prior to and after each stimulation session the participants were measured on speed and accuracy of performance on an n-back task.

RESULTS

There was significant improvement in speed of performance following anodal tDCS on the 2-back WM task; this was the only significant finding.

CONCLUSIONS

The results do not provide support for the hypothesis that tRNS improves WM. However, the study does provide confirmation of previous findings that anodal tDCS enhances some aspects of DLPFC functioning. Methodological limitations that may have contributed to the lack of significant findings following tRNS are discussed.

SIGNIFICANCE

Anodal tDCS may have significant implications for WM remediation in psychiatric conditions, particularly schizophrenia.

Authors+Show Affiliations

Monash Alfred Psychiatry Research Centre, The Alfred and Monash University, Department of Psychological Medicine, Commercial Rd., Melbourne, Victoria 3004, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21665534

Citation

Mulquiney, Paul G., et al. "Improving Working Memory: Exploring the Effect of Transcranial Random Noise Stimulation and Transcranial Direct Current Stimulation On the Dorsolateral Prefrontal Cortex." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 122, no. 12, 2011, pp. 2384-9.
Mulquiney PG, Hoy KE, Daskalakis ZJ, et al. Improving working memory: exploring the effect of transcranial random noise stimulation and transcranial direct current stimulation on the dorsolateral prefrontal cortex. Clin Neurophysiol. 2011;122(12):2384-9.
Mulquiney, P. G., Hoy, K. E., Daskalakis, Z. J., & Fitzgerald, P. B. (2011). Improving working memory: exploring the effect of transcranial random noise stimulation and transcranial direct current stimulation on the dorsolateral prefrontal cortex. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 122(12), 2384-9. https://doi.org/10.1016/j.clinph.2011.05.009
Mulquiney PG, et al. Improving Working Memory: Exploring the Effect of Transcranial Random Noise Stimulation and Transcranial Direct Current Stimulation On the Dorsolateral Prefrontal Cortex. Clin Neurophysiol. 2011;122(12):2384-9. PubMed PMID: 21665534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improving working memory: exploring the effect of transcranial random noise stimulation and transcranial direct current stimulation on the dorsolateral prefrontal cortex. AU - Mulquiney,Paul G, AU - Hoy,Kate E, AU - Daskalakis,Zafiris J, AU - Fitzgerald,Paul B, Y1 - 2011/06/12/ PY - 2011/01/05/received PY - 2011/05/11/revised PY - 2011/05/16/accepted PY - 2011/6/14/entrez PY - 2011/6/15/pubmed PY - 2012/1/5/medline SP - 2384 EP - 9 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 122 IS - 12 N2 - OBJECTIVE: The aim of this study was to determine if working memory (WM) performance is significantly improved after the delivery of transcranial random noise stimulation (tRNS) to the left dorsolateral prefrontal cortex (DLPFC), compared to an active comparator or sham. METHODS: Ten participants undertook three experimental sessions in which they received 10 min of anodal tDCS (active comparator), tRNS or sham tDCS whilst performing the Sternberg WM task. Intra-stimulation engagement in a WM task was undertaken as this has been previously shown to enhance the effects of tDCS. Experimental sessions were separated by a minimum of 1 week. Immediately prior to and after each stimulation session the participants were measured on speed and accuracy of performance on an n-back task. RESULTS: There was significant improvement in speed of performance following anodal tDCS on the 2-back WM task; this was the only significant finding. CONCLUSIONS: The results do not provide support for the hypothesis that tRNS improves WM. However, the study does provide confirmation of previous findings that anodal tDCS enhances some aspects of DLPFC functioning. Methodological limitations that may have contributed to the lack of significant findings following tRNS are discussed. SIGNIFICANCE: Anodal tDCS may have significant implications for WM remediation in psychiatric conditions, particularly schizophrenia. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/21665534/Improving_working_memory:_exploring_the_effect_of_transcranial_random_noise_stimulation_and_transcranial_direct_current_stimulation_on_the_dorsolateral_prefrontal_cortex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(11)00358-0 DB - PRIME DP - Unbound Medicine ER -