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Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors.

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a variety of clinical manifestations. Although inter-individual variations exist with respect to susceptibility to develop SLE, no study has been carried out to determine the role of different climate conditions in predisposing the susceptible individuals to SLE. The objective of this study was to investigate the role of different seasons and climate factors on SLE activity. From 2000 to 2009, the seasonal distribution of 2,802 active SLE patients recruited from Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University was analyzed retrospectively. The climate data were provided by the Institute of Geographical Sciences and Resources, Chinese Academy of Sciences. The correlation between climate factors and SLE activity was also analyzed. The proportion of active SLE patients in winter, spring, summer, and autumn was 10.06, 10.31, 9.74, and 8.66‰, respectively. In autumn, the proportion was much lower than that in winter and spring (P < 0.05). The proportion among winter, spring, and summer had no statistical difference (P > 0.05). The number of active SLE patients had no correlation with air temperature (r = 0.483, P > 0.05), relative humidity (r = -0.294, P > 0.05), and sunshine percentage (r = 0.503, P > 0.05), but it had positive correlation with amount of precipitation (r = 0.601, P < 0.05), wind velocity (r = 0.713, P < 0.01), and sunshine duration (r = 0.769, P < 0.01) and negative correlation with barometric pressure (r = -0.664, P < 0.05). The disease activity of patients with SLE is affected by seasons and climate factors.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People's Republic of China.

    , , , , ,

    Source

    Rheumatology international 32:8 2012 Aug pg 2393-9

    MeSH

    Adolescent
    Adult
    Aged
    Analysis of Variance
    Child
    China
    Disease Susceptibility
    Environment
    Female
    Humans
    Lupus Erythematosus, Systemic
    Male
    Middle Aged
    Retrospective Studies
    Risk Assessment
    Risk Factors
    Seasons
    Time Factors
    Weather
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21667078

    Citation

    Yang, Jie, et al. "Seasonal Distribution of Systemic Lupus Erythematosus Activity and Its Correlation With Climate Factors." Rheumatology International, vol. 32, no. 8, 2012, pp. 2393-9.
    Yang J, Lu YW, Pan HF, et al. Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors. Rheumatol Int. 2012;32(8):2393-9.
    Yang, J., Lu, Y. W., Pan, H. F., Tao, J. H., Zou, Y. F., Bao, W., & Ye, D. Q. (2012). Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors. Rheumatology International, 32(8), pp. 2393-9. doi:10.1007/s00296-011-1971-2.
    Yang J, et al. Seasonal Distribution of Systemic Lupus Erythematosus Activity and Its Correlation With Climate Factors. Rheumatol Int. 2012;32(8):2393-9. PubMed PMID: 21667078.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors. AU - Yang,Jie, AU - Lu,Yu-Wei, AU - Pan,Hai-Feng, AU - Tao,Jin-Hui, AU - Zou,Yan-Feng, AU - Bao,Wei, AU - Ye,Dong-Qing, Y1 - 2011/06/11/ PY - 2010/08/03/received PY - 2011/05/22/accepted PY - 2011/6/14/entrez PY - 2011/6/15/pubmed PY - 2012/12/12/medline SP - 2393 EP - 9 JF - Rheumatology international JO - Rheumatol. Int. VL - 32 IS - 8 N2 - Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a variety of clinical manifestations. Although inter-individual variations exist with respect to susceptibility to develop SLE, no study has been carried out to determine the role of different climate conditions in predisposing the susceptible individuals to SLE. The objective of this study was to investigate the role of different seasons and climate factors on SLE activity. From 2000 to 2009, the seasonal distribution of 2,802 active SLE patients recruited from Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University was analyzed retrospectively. The climate data were provided by the Institute of Geographical Sciences and Resources, Chinese Academy of Sciences. The correlation between climate factors and SLE activity was also analyzed. The proportion of active SLE patients in winter, spring, summer, and autumn was 10.06, 10.31, 9.74, and 8.66‰, respectively. In autumn, the proportion was much lower than that in winter and spring (P < 0.05). The proportion among winter, spring, and summer had no statistical difference (P > 0.05). The number of active SLE patients had no correlation with air temperature (r = 0.483, P > 0.05), relative humidity (r = -0.294, P > 0.05), and sunshine percentage (r = 0.503, P > 0.05), but it had positive correlation with amount of precipitation (r = 0.601, P < 0.05), wind velocity (r = 0.713, P < 0.01), and sunshine duration (r = 0.769, P < 0.01) and negative correlation with barometric pressure (r = -0.664, P < 0.05). The disease activity of patients with SLE is affected by seasons and climate factors. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/21667078/full_citation/Seasonal_distribution_of_systemic_lupus_erythematosus_activity_and_its_correlation_with_climate_factors_ L2 - https://dx.doi.org/10.1007/s00296-011-1971-2 DB - PRIME DP - Unbound Medicine ER -