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Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background.
J Ethnopharmacol. 2011 Sep 01; 137(1):937-41.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The aim of the study was to examine extracts from twelve tannin-rich plant materials used in traditional Polish medicine for external treatment of skin and mucosa diseases considering their ability to inhibit hyaluronidase activity and elastase release from stimulated neutrophils in vitro.

MATERIALS AND METHODS

In vitro anti-hyaluronidase and anti-elastase assays together with phytochemical qualitative and quantitative screening were performed.

RESULTS

The strongest inhibition of hyaluronidase was observed for extract from Lythri herba, with IC(50) value 8.1 ± 0.8 μg/mL. The most active extract towards elastase release was from Hippocastani cortex which at concentration 10 μg/mL showed 62.0 ± 6.9% inhibition.

CONCLUSION

Anti-hyaluronidase and anti-elastase activity of chosen tannin-rich plant materials can support their traditional use in folk medicine. Strong inhibition of both enzymes by extract from Lythri herba makes this pharmacopeial plant material an interesting topic for further biological and phytochemical examination.

Authors+Show Affiliations

Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Faculty of Pharmacy ul. Banacha 1, 02-097 Warsaw, Poland. jakub.piwowarski@wum.edu.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21669271

Citation

Piwowarski, Jakub P., et al. "Anti-hyaluronidase and Anti-elastase Activity Screening of Tannin-rich Plant Materials Used in Traditional Polish Medicine for External Treatment of Diseases With Inflammatory Background." Journal of Ethnopharmacology, vol. 137, no. 1, 2011, pp. 937-41.
Piwowarski JP, Kiss AK, Kozłowska-Wojciechowska M. Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background. J Ethnopharmacol. 2011;137(1):937-41.
Piwowarski, J. P., Kiss, A. K., & Kozłowska-Wojciechowska, M. (2011). Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background. Journal of Ethnopharmacology, 137(1), 937-41. https://doi.org/10.1016/j.jep.2011.05.039
Piwowarski JP, Kiss AK, Kozłowska-Wojciechowska M. Anti-hyaluronidase and Anti-elastase Activity Screening of Tannin-rich Plant Materials Used in Traditional Polish Medicine for External Treatment of Diseases With Inflammatory Background. J Ethnopharmacol. 2011 Sep 1;137(1):937-41. PubMed PMID: 21669271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background. AU - Piwowarski,Jakub P, AU - Kiss,Anna K, AU - Kozłowska-Wojciechowska,Małgorzata, Y1 - 2011/06/06/ PY - 2011/03/03/received PY - 2011/05/23/revised PY - 2011/05/26/accepted PY - 2011/6/15/entrez PY - 2011/6/15/pubmed PY - 2011/12/28/medline SP - 937 EP - 41 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The aim of the study was to examine extracts from twelve tannin-rich plant materials used in traditional Polish medicine for external treatment of skin and mucosa diseases considering their ability to inhibit hyaluronidase activity and elastase release from stimulated neutrophils in vitro. MATERIALS AND METHODS: In vitro anti-hyaluronidase and anti-elastase assays together with phytochemical qualitative and quantitative screening were performed. RESULTS: The strongest inhibition of hyaluronidase was observed for extract from Lythri herba, with IC(50) value 8.1 ± 0.8 μg/mL. The most active extract towards elastase release was from Hippocastani cortex which at concentration 10 μg/mL showed 62.0 ± 6.9% inhibition. CONCLUSION: Anti-hyaluronidase and anti-elastase activity of chosen tannin-rich plant materials can support their traditional use in folk medicine. Strong inhibition of both enzymes by extract from Lythri herba makes this pharmacopeial plant material an interesting topic for further biological and phytochemical examination. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21669271/Anti_hyaluronidase_and_anti_elastase_activity_screening_of_tannin_rich_plant_materials_used_in_traditional_Polish_medicine_for_external_treatment_of_diseases_with_inflammatory_background_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00404-1 DB - PRIME DP - Unbound Medicine ER -