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Foveal microstructure on spectral-domain optical coherence tomographic images and visual function after macular hole surgery.
Am J Ophthalmol. 2011 Aug; 152(2):283-290.e1.AJ

Abstract

PURPOSE

To determine the correlation between the recovery of foveal microstructure and the visual acuity or the foveal sensitivity after idiopathic macular hole (MH) closure.

DESIGN

Prospective, consecutive, observational case series.

METHODS

We studied 43 eyes of 43 patients before and 1, 3, and 6 months after MH surgery. The best-corrected visual acuity (BCVA), the foveal sensitivity measured by MP1 microperimetry, and the photoreceptor inner and outer segment (IS/OS) junction and the external limiting membrane (ELM) determined by spectral-domain optical coherence tomography were investigated.

RESULTS

Preoperatively, the lengths of the IS/OS junction defect and the ELM defect were significantly correlated with only the foveal sensitivity (P<.0001). At all postoperative times, the lengths of both the IS/OS and ELM defects were significantly correlated with both the BCVA and the foveal sensitivity (P<.05 for all). The preoperative lengths of both the IS/OS and ELM defects were significantly correlated with the foveal sensitivity at 6 months after surgery (P=.0022, P=.0031, respectively). The IS/OS junction defect was significantly correlated with the ELM defect at all times (P<.0001 for all). No restoration of the IS/OS junction was observed in eyes without the ELM restoration.

CONCLUSIONS

The restoration of the ELM is closely associated with that of the IS/OS junction. The preoperative IS/OS or ELM defect was associated with the postoperative foveal sensitivity. The restoration of not only the IS/OS junction but also the ELM may reflect the morphologic and functional recovery of the foveal photoreceptors in surgically closed MHs.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21669402

Citation

Ooka, Emi, et al. "Foveal Microstructure On Spectral-domain Optical Coherence Tomographic Images and Visual Function After Macular Hole Surgery." American Journal of Ophthalmology, vol. 152, no. 2, 2011, pp. 283-290.e1.
Ooka E, Mitamura Y, Baba T, et al. Foveal microstructure on spectral-domain optical coherence tomographic images and visual function after macular hole surgery. Am J Ophthalmol. 2011;152(2):283-290.e1.
Ooka, E., Mitamura, Y., Baba, T., Kitahashi, M., Oshitari, T., & Yamamoto, S. (2011). Foveal microstructure on spectral-domain optical coherence tomographic images and visual function after macular hole surgery. American Journal of Ophthalmology, 152(2), 283-e1. https://doi.org/10.1016/j.ajo.2011.02.001
Ooka E, et al. Foveal Microstructure On Spectral-domain Optical Coherence Tomographic Images and Visual Function After Macular Hole Surgery. Am J Ophthalmol. 2011;152(2):283-290.e1. PubMed PMID: 21669402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Foveal microstructure on spectral-domain optical coherence tomographic images and visual function after macular hole surgery. AU - Ooka,Emi, AU - Mitamura,Yoshinori, AU - Baba,Takayuki, AU - Kitahashi,Masayasu, AU - Oshitari,Toshiyuki, AU - Yamamoto,Shuichi, Y1 - 2011/06/12/ PY - 2010/11/25/received PY - 2011/02/02/revised PY - 2011/02/02/accepted PY - 2011/6/15/entrez PY - 2011/6/15/pubmed PY - 2011/9/16/medline SP - 283 EP - 290.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 152 IS - 2 N2 - PURPOSE: To determine the correlation between the recovery of foveal microstructure and the visual acuity or the foveal sensitivity after idiopathic macular hole (MH) closure. DESIGN: Prospective, consecutive, observational case series. METHODS: We studied 43 eyes of 43 patients before and 1, 3, and 6 months after MH surgery. The best-corrected visual acuity (BCVA), the foveal sensitivity measured by MP1 microperimetry, and the photoreceptor inner and outer segment (IS/OS) junction and the external limiting membrane (ELM) determined by spectral-domain optical coherence tomography were investigated. RESULTS: Preoperatively, the lengths of the IS/OS junction defect and the ELM defect were significantly correlated with only the foveal sensitivity (P<.0001). At all postoperative times, the lengths of both the IS/OS and ELM defects were significantly correlated with both the BCVA and the foveal sensitivity (P<.05 for all). The preoperative lengths of both the IS/OS and ELM defects were significantly correlated with the foveal sensitivity at 6 months after surgery (P=.0022, P=.0031, respectively). The IS/OS junction defect was significantly correlated with the ELM defect at all times (P<.0001 for all). No restoration of the IS/OS junction was observed in eyes without the ELM restoration. CONCLUSIONS: The restoration of the ELM is closely associated with that of the IS/OS junction. The preoperative IS/OS or ELM defect was associated with the postoperative foveal sensitivity. The restoration of not only the IS/OS junction but also the ELM may reflect the morphologic and functional recovery of the foveal photoreceptors in surgically closed MHs. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/21669402/Foveal_microstructure_on_spectral_domain_optical_coherence_tomographic_images_and_visual_function_after_macular_hole_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(11)00145-0 DB - PRIME DP - Unbound Medicine ER -