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Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study.

Abstract

OBJECTIVE

To investigate whether dietary nutrients can reduce the genetic risk of early age-related macular degeneration (AMD) conferred by the genetic variants CFH Y402H and LOC387715 A69S in a nested case-control study.

METHODS

For 2167 individuals (≥55 years) from the population-based Rotterdam Study at risk of AMD, dietary intake was assessed at baseline using a semiquantitative food frequency questionnaire and genetic variants were determined using TaqMan assay. Incident early AMD was determined on fundus photographs at 3 follow-up visits (median follow-up, 8.6 years). The synergy index was used to evaluate biological interaction between risk factors; hazard ratios were calculated to estimate risk of early AMD in strata of nutrient intake and genotypes.

RESULTS

Five hundred seventeen participants developed early AMD. Significant synergy indices supported the possibility of biological interaction between CFH Y402H and zinc, β-carotene, lutein/zeaxanthin, and eicosapentaenoic/docosahexaenoic acid (EPA/DHA) and between LOC387715 A69S and zinc and EPA/DHA (all P < .05). Homozygotes of CFH Y402H with dietary intake of zinc in the highest tertile reduced their hazard ratio of early AMD from 2.25 to 1.27. For intakes of β-carotene, lutein/zeaxanthin, and EPA/DHA, these risk reductions were from 2.54 to 1.47, 2.63 to 1.72, and 1.97 to 1.30, respectively. Carriers of LOC387715 A69S with the highest intake of zinc and EPA/DHA reduced their risk from 1.70 to 1.17 and 1.59 to 0.95, respectively (all P trends <.05).

CONCLUSIONS

High dietary intake of nutrients with antioxidant properties reduces the risk of early AMD in those at high genetic risk. Therefore, clinicians should provide dietary advice to young susceptible individuals to postpone or prevent the vision-disabling consequences of AMD.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Ophthalmology, Erasmus Medical Center Rotterdam, 3000 CA Rotterdam, the Netherlands.

    , , , , , , ,

    Source

    MeSH

    Aged
    Antioxidants
    Blindness
    Dietary Supplements
    Fatty Acids, Omega-3
    Female
    Follow-Up Studies
    Genetic Predisposition to Disease
    Humans
    Incidence
    Macular Degeneration
    Male
    Middle Aged
    Netherlands
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Treatment Outcome
    Visual Acuity
    Zinc

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21670343

    Citation

    Ho, Lintje, et al. "Reducing the Genetic Risk of Age-related Macular Degeneration With Dietary Antioxidants, Zinc, and Ω-3 Fatty Acids: the Rotterdam Study." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 129, no. 6, 2011, pp. 758-66.
    Ho L, van Leeuwen R, Witteman JC, et al. Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study. Arch Ophthalmol. 2011;129(6):758-66.
    Ho, L., van Leeuwen, R., Witteman, J. C., van Duijn, C. M., Uitterlinden, A. G., Hofman, A., ... Klaver, C. C. (2011). Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study. Archives of Ophthalmology (Chicago, Ill. : 1960), 129(6), pp. 758-66. doi:10.1001/archophthalmol.2011.141.
    Ho L, et al. Reducing the Genetic Risk of Age-related Macular Degeneration With Dietary Antioxidants, Zinc, and Ω-3 Fatty Acids: the Rotterdam Study. Arch Ophthalmol. 2011;129(6):758-66. PubMed PMID: 21670343.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study. AU - Ho,Lintje, AU - van Leeuwen,Redmer, AU - Witteman,Jacqueline C M, AU - van Duijn,Cornelia M, AU - Uitterlinden,André G, AU - Hofman,Albert, AU - de Jong,Paulus T V M, AU - Vingerling,Johannes R, AU - Klaver,Caroline C W, PY - 2011/6/15/entrez PY - 2011/6/15/pubmed PY - 2011/8/13/medline SP - 758 EP - 66 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 129 IS - 6 N2 - OBJECTIVE: To investigate whether dietary nutrients can reduce the genetic risk of early age-related macular degeneration (AMD) conferred by the genetic variants CFH Y402H and LOC387715 A69S in a nested case-control study. METHODS: For 2167 individuals (≥55 years) from the population-based Rotterdam Study at risk of AMD, dietary intake was assessed at baseline using a semiquantitative food frequency questionnaire and genetic variants were determined using TaqMan assay. Incident early AMD was determined on fundus photographs at 3 follow-up visits (median follow-up, 8.6 years). The synergy index was used to evaluate biological interaction between risk factors; hazard ratios were calculated to estimate risk of early AMD in strata of nutrient intake and genotypes. RESULTS: Five hundred seventeen participants developed early AMD. Significant synergy indices supported the possibility of biological interaction between CFH Y402H and zinc, β-carotene, lutein/zeaxanthin, and eicosapentaenoic/docosahexaenoic acid (EPA/DHA) and between LOC387715 A69S and zinc and EPA/DHA (all P < .05). Homozygotes of CFH Y402H with dietary intake of zinc in the highest tertile reduced their hazard ratio of early AMD from 2.25 to 1.27. For intakes of β-carotene, lutein/zeaxanthin, and EPA/DHA, these risk reductions were from 2.54 to 1.47, 2.63 to 1.72, and 1.97 to 1.30, respectively. Carriers of LOC387715 A69S with the highest intake of zinc and EPA/DHA reduced their risk from 1.70 to 1.17 and 1.59 to 0.95, respectively (all P trends <.05). CONCLUSIONS: High dietary intake of nutrients with antioxidant properties reduces the risk of early AMD in those at high genetic risk. Therefore, clinicians should provide dietary advice to young susceptible individuals to postpone or prevent the vision-disabling consequences of AMD. SN - 1538-3601 UR - https://www.unboundmedicine.com/medline/citation/21670343/Reducing_the_genetic_risk_of_age_related_macular_degeneration_with_dietary_antioxidants_zinc_and_ω_3_fatty_acids:_the_Rotterdam_study_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archophthalmol.2011.141 DB - PRIME DP - Unbound Medicine ER -