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The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis.
Clin Exp Allergy. 2011 Nov; 41(11):1515-20.CE

Abstract

Atopic dermatitis (AD), a skin disease characterized by pruritus and chronic inflammation, results from a complex interplay between environmental and genetic factors. Thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is believed to propagate AD lesions through T helper 2 (Th2) polarization. This paper describes the immunologic mechanisms involving TSLP in the generation of allergic disease. Specifically in AD, TSLP has been shown to be an inducer of myeloid dendritic cells, Th2 responses, mast cells, and natural killer T cells, thereby leading to cytokine secretion and the development of AD. We hope that further understanding of the TSLP pathway and its role in the pathogenesis of AD will lead to improved clinical management of AD in the future.

Authors+Show Affiliations

Allergy/Immunology Division, Albert Einstein College of Medicine, Bronx, NY 10463, USA. sjariwal@montefiore.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21672057

Citation

Jariwala, S P., et al. "The Role of Thymic Stromal Lymphopoietin in the Immunopathogenesis of Atopic Dermatitis." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 41, no. 11, 2011, pp. 1515-20.
Jariwala SP, Abrams E, Benson A, et al. The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis. Clin Exp Allergy. 2011;41(11):1515-20.
Jariwala, S. P., Abrams, E., Benson, A., Fodeman, J., & Zheng, T. (2011). The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 41(11), 1515-20. https://doi.org/10.1111/j.1365-2222.2011.03797.x
Jariwala SP, et al. The Role of Thymic Stromal Lymphopoietin in the Immunopathogenesis of Atopic Dermatitis. Clin Exp Allergy. 2011;41(11):1515-20. PubMed PMID: 21672057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis. AU - Jariwala,S P, AU - Abrams,E, AU - Benson,A, AU - Fodeman,J, AU - Zheng,T, Y1 - 2011/06/14/ PY - 2011/6/16/entrez PY - 2011/6/16/pubmed PY - 2012/7/10/medline SP - 1515 EP - 20 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 41 IS - 11 N2 - Atopic dermatitis (AD), a skin disease characterized by pruritus and chronic inflammation, results from a complex interplay between environmental and genetic factors. Thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is believed to propagate AD lesions through T helper 2 (Th2) polarization. This paper describes the immunologic mechanisms involving TSLP in the generation of allergic disease. Specifically in AD, TSLP has been shown to be an inducer of myeloid dendritic cells, Th2 responses, mast cells, and natural killer T cells, thereby leading to cytokine secretion and the development of AD. We hope that further understanding of the TSLP pathway and its role in the pathogenesis of AD will lead to improved clinical management of AD in the future. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/21672057/The_role_of_thymic_stromal_lymphopoietin_in_the_immunopathogenesis_of_atopic_dermatitis_ L2 - https://doi.org/10.1111/j.1365-2222.2011.03797.x DB - PRIME DP - Unbound Medicine ER -