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Dose range finding study for the efficacy of meloxicam administered prior to sodium urate-induced synovitis in cats.
Vet Anaesth Analg 2011; 38(4):394-406VA

Abstract

OBJECTIVE

To determine the lowest efficacious dose of oral meloxicam for relieving pain in cats with a sodium urate (SU)-induced acute inflammatory synovitis.

STUDY DESIGN

Randomized, blinded, controlled, and four-way crossover study.

ANIMALS

Eight surgically neutered cats (four males, four females) paired according to sex.

METHODS

Each pair of cats was treated with 0 (placebo), 0.025, 0.05, or 0.075 mg kg(-1) oral meloxicam once daily for 4 days prior to injection, into alternating stifles, of 1 mL of 20 mg mL(-1) SU crystals, beginning with the right stifle. Each cat received each of the four treatments, separated by at least 21 days. Analgesic efficacy was evaluated based on objective (e.g., pressure mat data total force, contact pressure, and contact area) and subjective (e.g., scores for Analgesia Scale [AS], Lameness Scale [LS], and Visual Analog Scale [VAS]) outcome measures for pain assessment. All outcome measures were recorded before and during 30 hours after SU injection. The pre-defined primary outcome measure was the area under the response-time curve (AUC(0-30) hours) of the total force of the injected limb. Data were analyzed by analysis of variance. A sequential test procedure was applied and the test sequence stopped in case of a nonsignificant result.

RESULTS

Meloxicam at doses of 0.05 and 0.075 mg kg(-1) day(-1) PO was significantly different from placebo for the pre-defined primary outcome measure (i.e., AUC(0-30) hours of total force). All tested meloxicam doses were lower than placebo for the subjective outcome measures (i.e., AUC(0-30) hours of AS, LS, and VAS).

CONCLUSIONS AND CLINICAL RELEVANCE

The lowest efficacious dose of meloxicam for relieving pain in cats with an SU-induced synovitis was 0.05 mg kg(-1) day(-1) PO according to the pre-defined primary outcome measure. However, lower doses may also be effective as seen in the subjective outcome measures.

Authors+Show Affiliations

Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX 77843-4474, USA. gcarroll@cvm.tamu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21672128

Citation

Carroll, Gwendolyn L., et al. "Dose Range Finding Study for the Efficacy of Meloxicam Administered Prior to Sodium Urate-induced Synovitis in Cats." Veterinary Anaesthesia and Analgesia, vol. 38, no. 4, 2011, pp. 394-406.
Carroll GL, Narbe R, Kerwin SC, et al. Dose range finding study for the efficacy of meloxicam administered prior to sodium urate-induced synovitis in cats. Vet Anaesth Analg. 2011;38(4):394-406.
Carroll, G. L., Narbe, R., Kerwin, S. C., Taylor, L., Peterson, K., & Hartsfield, S. M. (2011). Dose range finding study for the efficacy of meloxicam administered prior to sodium urate-induced synovitis in cats. Veterinary Anaesthesia and Analgesia, 38(4), pp. 394-406. doi:10.1111/j.1467-2995.2011.00621.x.
Carroll GL, et al. Dose Range Finding Study for the Efficacy of Meloxicam Administered Prior to Sodium Urate-induced Synovitis in Cats. Vet Anaesth Analg. 2011;38(4):394-406. PubMed PMID: 21672128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose range finding study for the efficacy of meloxicam administered prior to sodium urate-induced synovitis in cats. AU - Carroll,Gwendolyn L, AU - Narbe,Ruediger, AU - Kerwin,Sharon C, AU - Taylor,Lathrop, AU - Peterson,Kurt, AU - Hartsfield,Sandee M, PY - 2011/6/16/entrez PY - 2011/6/16/pubmed PY - 2012/1/6/medline SP - 394 EP - 406 JF - Veterinary anaesthesia and analgesia JO - Vet Anaesth Analg VL - 38 IS - 4 N2 - OBJECTIVE: To determine the lowest efficacious dose of oral meloxicam for relieving pain in cats with a sodium urate (SU)-induced acute inflammatory synovitis. STUDY DESIGN: Randomized, blinded, controlled, and four-way crossover study. ANIMALS: Eight surgically neutered cats (four males, four females) paired according to sex. METHODS: Each pair of cats was treated with 0 (placebo), 0.025, 0.05, or 0.075 mg kg(-1) oral meloxicam once daily for 4 days prior to injection, into alternating stifles, of 1 mL of 20 mg mL(-1) SU crystals, beginning with the right stifle. Each cat received each of the four treatments, separated by at least 21 days. Analgesic efficacy was evaluated based on objective (e.g., pressure mat data total force, contact pressure, and contact area) and subjective (e.g., scores for Analgesia Scale [AS], Lameness Scale [LS], and Visual Analog Scale [VAS]) outcome measures for pain assessment. All outcome measures were recorded before and during 30 hours after SU injection. The pre-defined primary outcome measure was the area under the response-time curve (AUC(0-30) hours) of the total force of the injected limb. Data were analyzed by analysis of variance. A sequential test procedure was applied and the test sequence stopped in case of a nonsignificant result. RESULTS: Meloxicam at doses of 0.05 and 0.075 mg kg(-1) day(-1) PO was significantly different from placebo for the pre-defined primary outcome measure (i.e., AUC(0-30) hours of total force). All tested meloxicam doses were lower than placebo for the subjective outcome measures (i.e., AUC(0-30) hours of AS, LS, and VAS). CONCLUSIONS AND CLINICAL RELEVANCE: The lowest efficacious dose of meloxicam for relieving pain in cats with an SU-induced synovitis was 0.05 mg kg(-1) day(-1) PO according to the pre-defined primary outcome measure. However, lower doses may also be effective as seen in the subjective outcome measures. SN - 1467-2995 UR - https://www.unboundmedicine.com/medline/citation/21672128/Dose_range_finding_study_for_the_efficacy_of_meloxicam_administered_prior_to_sodium_urate_induced_synovitis_in_cats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1467-2987(16)30674-2 DB - PRIME DP - Unbound Medicine ER -