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Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis.
Am J Transplant. 2011 Jul; 11(7):1456-63.AJ

Abstract

Screening renal biopsies (RB) may assess early changes of interstitial fibrosis (IF) after transplantation. The aim of this study was to quantify IF by automatic color image analysis on sequential RB. We analyzed RB performed at day (D) 0, month (M) 3 and M12 from 140 renal transplant recipients with a program of color segmentation imaging. The mean IF score was 19 ± 9% at D0, 27 ± 11% at M3 and 32 ± 11% at M12 with a 8% progression during the first 3 months and 5% between M3 and M12. IF at M3 was correlated with estimated glomerular rate (eGFR) at M3, 12 and 24 (p < 0.02) and IF at M12 with eGFR at M12 and 48 (p < 0.05). Furthermore, IF evolution between D0 and M3 (ΔIFM3-D0) was correlated with eGFR at M24, 36 and 48 (p < 0.03). IF at M12 was significantly associated with male donor gender and tacrolimus dose (p = 0.03). ΔIFM3-D0 was significantly associated with male donor gender, acute rejection episodes (p = 0.04) and diabetes mellitus (p = 0.02). Thus, significant IF is already present before transplantation. IF evolution is more important during the first 3 months and has some predictive ability for change in GFR. Intervention to decrease IF should be applied early, i.e. before 3 months, after transplantation.

Authors+Show Affiliations

Department of Nephrology, Assistance publique-Hôpitaux de Paris, Necker-Enfants Malades Hospital, Paris, France. aude.servais@nck.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21672152

Citation

Servais, A, et al. "Interstitial Fibrosis Evolution On Early Sequential Screening Renal Allograft Biopsies Using Quantitative Image Analysis." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 11, no. 7, 2011, pp. 1456-63.
Servais A, Meas-Yedid V, Noël LH, et al. Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis. Am J Transplant. 2011;11(7):1456-63.
Servais, A., Meas-Yedid, V., Noël, L. H., Martinez, F., Panterne, C., Kreis, H., Zuber, J., Timsit, M. O., Legendre, C. h., Olivo-Marin, J. C., & Thervet, E. (2011). Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 11(7), 1456-63. https://doi.org/10.1111/j.1600-6143.2011.03594.x
Servais A, et al. Interstitial Fibrosis Evolution On Early Sequential Screening Renal Allograft Biopsies Using Quantitative Image Analysis. Am J Transplant. 2011;11(7):1456-63. PubMed PMID: 21672152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis. AU - Servais,A, AU - Meas-Yedid,V, AU - Noël,L H, AU - Martinez,F, AU - Panterne,C, AU - Kreis,H, AU - Zuber,J, AU - Timsit,M O, AU - Legendre,Ch, AU - Olivo-Marin,J C, AU - Thervet,E, Y1 - 2011/06/14/ PY - 2011/6/16/entrez PY - 2011/6/16/pubmed PY - 2011/11/1/medline SP - 1456 EP - 63 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am. J. Transplant. VL - 11 IS - 7 N2 - Screening renal biopsies (RB) may assess early changes of interstitial fibrosis (IF) after transplantation. The aim of this study was to quantify IF by automatic color image analysis on sequential RB. We analyzed RB performed at day (D) 0, month (M) 3 and M12 from 140 renal transplant recipients with a program of color segmentation imaging. The mean IF score was 19 ± 9% at D0, 27 ± 11% at M3 and 32 ± 11% at M12 with a 8% progression during the first 3 months and 5% between M3 and M12. IF at M3 was correlated with estimated glomerular rate (eGFR) at M3, 12 and 24 (p < 0.02) and IF at M12 with eGFR at M12 and 48 (p < 0.05). Furthermore, IF evolution between D0 and M3 (ΔIFM3-D0) was correlated with eGFR at M24, 36 and 48 (p < 0.03). IF at M12 was significantly associated with male donor gender and tacrolimus dose (p = 0.03). ΔIFM3-D0 was significantly associated with male donor gender, acute rejection episodes (p = 0.04) and diabetes mellitus (p = 0.02). Thus, significant IF is already present before transplantation. IF evolution is more important during the first 3 months and has some predictive ability for change in GFR. Intervention to decrease IF should be applied early, i.e. before 3 months, after transplantation. SN - 1600-6143 UR - https://www.unboundmedicine.com/medline/citation/21672152/abstract/Interstitial_Fibrosis_Evolution_on_Early_Sequential_Screening_Renal_Allograft_Biopsies_Using_Quantitative_Image_Analysis_ L2 - https://doi.org/10.1111/j.1600-6143.2011.03594.x DB - PRIME DP - Unbound Medicine ER -