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Meta-analysis: Serum vitamin D and colorectal adenoma risk.
Prev Med. 2011 Jul-Aug; 53(1-2):10-6.PM

Abstract

OBJECTIVE

To perform a systematic review and meta-analysis of human studies on the association between serum 25 hydroxyvitamin D (25(OH)D) and incident, sporadic colorectal adenoma (CRA) and CRA recurrence.

METHODS

Relevant studies among humans were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. Due to the heterogeneity across studies in categorizing serum vitamin D levels, all results were recalculated for an increase of serum 25(OH)D by 20 ng/ml. Summary odds ratios (ORs) were calculated using meta-analysis methods.

RESULTS

Overall, 10 original studies were included. Specific results for incident CRA according to serum 25(OH)D were reported in 8 studies, and for CRA recurrence in 2 studies, respectively. In meta-analyses, summary ORs (95% confidence intervals) regarding incident and recurrent CRA, and both outcomes combined were 0.82 (0.69-0.97), 0.87 (0.56-1.35), and 0.84 (0.72-0.97), respectively, for an increase of 25(OH)D by 20 ng/ml. No publication bias was found.

CONCLUSION

Our results support suggestions that serum 25(OH)D levels are inversely associated with CRA risk.

Authors+Show Affiliations

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg, GermanyNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

21672549

Citation

Yin, Lu, et al. "Meta-analysis: Serum Vitamin D and Colorectal Adenoma Risk." Preventive Medicine, vol. 53, no. 1-2, 2011, pp. 10-6.
Yin L, Grandi N, Raum E, et al. Meta-analysis: Serum vitamin D and colorectal adenoma risk. Prev Med. 2011;53(1-2):10-6.
Yin, L., Grandi, N., Raum, E., Haug, U., Arndt, V., & Brenner, H. (2011). Meta-analysis: Serum vitamin D and colorectal adenoma risk. Preventive Medicine, 53(1-2), 10-6. https://doi.org/10.1016/j.ypmed.2011.05.013
Yin L, et al. Meta-analysis: Serum Vitamin D and Colorectal Adenoma Risk. Prev Med. 2011;53(1-2):10-6. PubMed PMID: 21672549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis: Serum vitamin D and colorectal adenoma risk. AU - Yin,Lu, AU - Grandi,Norma, AU - Raum,Elke, AU - Haug,Ulrike, AU - Arndt,Volker, AU - Brenner,Hermann, Y1 - 2011/06/13/ PY - 2010/12/09/received PY - 2011/05/19/revised PY - 2011/05/25/accepted PY - 2011/6/16/entrez PY - 2011/6/16/pubmed PY - 2011/12/14/medline SP - 10 EP - 6 JF - Preventive medicine JO - Prev Med VL - 53 IS - 1-2 N2 - OBJECTIVE: To perform a systematic review and meta-analysis of human studies on the association between serum 25 hydroxyvitamin D (25(OH)D) and incident, sporadic colorectal adenoma (CRA) and CRA recurrence. METHODS: Relevant studies among humans were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. Due to the heterogeneity across studies in categorizing serum vitamin D levels, all results were recalculated for an increase of serum 25(OH)D by 20 ng/ml. Summary odds ratios (ORs) were calculated using meta-analysis methods. RESULTS: Overall, 10 original studies were included. Specific results for incident CRA according to serum 25(OH)D were reported in 8 studies, and for CRA recurrence in 2 studies, respectively. In meta-analyses, summary ORs (95% confidence intervals) regarding incident and recurrent CRA, and both outcomes combined were 0.82 (0.69-0.97), 0.87 (0.56-1.35), and 0.84 (0.72-0.97), respectively, for an increase of 25(OH)D by 20 ng/ml. No publication bias was found. CONCLUSION: Our results support suggestions that serum 25(OH)D levels are inversely associated with CRA risk. SN - 1096-0260 UR - https://www.unboundmedicine.com/medline/citation/21672549/Meta_analysis:_Serum_vitamin_D_and_colorectal_adenoma_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-7435(11)00221-0 DB - PRIME DP - Unbound Medicine ER -