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Triglyceride-high-density lipoprotein cholesterol is associated with microvascular complications in type 2 diabetes mellitus.
Metabolism. 2012 Jan; 61(1):22-9.M

Abstract

The purpose of this study was to evaluate whether a high triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is associated with an increased incidence of retinopathy and chronic kidney disease (CKD) in type 2 diabetes mellitus. Individuals with type 2 diabetes mellitus (n = 979) with an estimated glomerular filtration rate greater than 60 mL/min and without retinopathy and cardiovascular disease at baseline were followed up for the incidence of diabetic retinopathy (diagnosed by retinography) and CKD (diagnosed by estimated glomerular filtration rate ≤60 mL/min/1.73 m(2)). On follow-up (mean, 4.9 years), 217 (22.2% of total) subjects experienced CKD and/or diabetic-specific retinal lesions (microvascular complication). Of these, 111 subjects developed isolated retinopathy, 85 developed CKD alone, and 21 developed both complications. The TG/HDL-C ratio was positively associated with an increased risk of incident retinopathy and/or CKD (composite microvascular end point) independently of age, sex, body mass index, diabetes duration, hemoglobin A(1c), hypertension, smoking history, low-density lipoprotein cholesterol, albuminuria, and current use of hypoglycemic, antihypertensive, lipid-lowering, or antiplatelet drugs (multivariable-adjusted odds ratio, 2.15; 95% confidence intervals, 1.10-4.25; P = .04). These findings suggested that the TG/HDL-C ratio was associated with an increased incidence of microvascular complications in individuals with type 2 diabetes mellitus without prior cardiovascular disease, independently of several potential confounders.

Authors+Show Affiliations

Department of Medicine, Section of Endocrinology and Metabolic Diseases, University of Verona, Verona, Italy. giacomo.zoppini@univr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21676418

Citation

Zoppini, Giacomo, et al. "Triglyceride-high-density Lipoprotein Cholesterol Is Associated With Microvascular Complications in Type 2 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 61, no. 1, 2012, pp. 22-9.
Zoppini G, Negri C, Stoico V, et al. Triglyceride-high-density lipoprotein cholesterol is associated with microvascular complications in type 2 diabetes mellitus. Metabolism. 2012;61(1):22-9.
Zoppini, G., Negri, C., Stoico, V., Casati, S., Pichiri, I., & Bonora, E. (2012). Triglyceride-high-density lipoprotein cholesterol is associated with microvascular complications in type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 61(1), 22-9. https://doi.org/10.1016/j.metabol.2011.05.004
Zoppini G, et al. Triglyceride-high-density Lipoprotein Cholesterol Is Associated With Microvascular Complications in Type 2 Diabetes Mellitus. Metabolism. 2012;61(1):22-9. PubMed PMID: 21676418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triglyceride-high-density lipoprotein cholesterol is associated with microvascular complications in type 2 diabetes mellitus. AU - Zoppini,Giacomo, AU - Negri,Carlo, AU - Stoico,Vincenzo, AU - Casati,Stefano, AU - Pichiri,Isabella, AU - Bonora,Enzo, Y1 - 2011/06/14/ PY - 2011/02/02/received PY - 2011/04/22/revised PY - 2011/05/03/accepted PY - 2011/6/17/entrez PY - 2011/6/17/pubmed PY - 2012/4/6/medline SP - 22 EP - 9 JF - Metabolism: clinical and experimental JO - Metabolism VL - 61 IS - 1 N2 - The purpose of this study was to evaluate whether a high triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is associated with an increased incidence of retinopathy and chronic kidney disease (CKD) in type 2 diabetes mellitus. Individuals with type 2 diabetes mellitus (n = 979) with an estimated glomerular filtration rate greater than 60 mL/min and without retinopathy and cardiovascular disease at baseline were followed up for the incidence of diabetic retinopathy (diagnosed by retinography) and CKD (diagnosed by estimated glomerular filtration rate ≤60 mL/min/1.73 m(2)). On follow-up (mean, 4.9 years), 217 (22.2% of total) subjects experienced CKD and/or diabetic-specific retinal lesions (microvascular complication). Of these, 111 subjects developed isolated retinopathy, 85 developed CKD alone, and 21 developed both complications. The TG/HDL-C ratio was positively associated with an increased risk of incident retinopathy and/or CKD (composite microvascular end point) independently of age, sex, body mass index, diabetes duration, hemoglobin A(1c), hypertension, smoking history, low-density lipoprotein cholesterol, albuminuria, and current use of hypoglycemic, antihypertensive, lipid-lowering, or antiplatelet drugs (multivariable-adjusted odds ratio, 2.15; 95% confidence intervals, 1.10-4.25; P = .04). These findings suggested that the TG/HDL-C ratio was associated with an increased incidence of microvascular complications in individuals with type 2 diabetes mellitus without prior cardiovascular disease, independently of several potential confounders. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/21676418/Triglyceride_high_density_lipoprotein_cholesterol_is_associated_with_microvascular_complications_in_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(11)00129-6 DB - PRIME DP - Unbound Medicine ER -