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Influence of age, gender and severity of tremor on outcome after thalamic and subthalamic DBS for essential tremor.
Parkinsonism Relat Disord. 2011 Sep; 17(8):617-20.PR

Abstract

Deep brain stimulation (DBS) is an established treatment for essential tremor (ET). The nucleus ventralis intermedius thalami (Vim) is the target of choice, but promising results have been presented regarding DBS in the posterior subthalamic area (PSA). The aim of this study was to evaluate the possible influence of gender, age and severity of disease on the outcome of these procedures. Sixty eight patients (34 Vim, 34 PSA) with ET were included in this non-randomised study. Evaluation using the Essential Tremor Rating Scale (ETRS) was performed before, and one year after surgery concerning PSA DBS, and at a mean of 28 ± 24 months concerning Vim DBS. Items 5/6 and 11-14 (hand tremor and hand function) were selected for analysis of tremor outcome. The efficacy of DBS on essential tremor was not related to age or gender. Nor was it associated with the severity of tremor when the percentual reduction of tremor on stimulation was taken into account. However, patients with a more severe tremor at baseline had a higher degree of residual tremor on stimulation. Tremor in the treated hand and hand function were improved with 70% in the Vim group and 89% in the PSA group.

Authors+Show Affiliations

Department of Clinical Neuroscience, Section of Neurosurgery, Umeå University, Sweden. patric.blomstedt@neuro.umu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21676643

Citation

Blomstedt, Patric, et al. "Influence of Age, Gender and Severity of Tremor On Outcome After Thalamic and Subthalamic DBS for Essential Tremor." Parkinsonism & Related Disorders, vol. 17, no. 8, 2011, pp. 617-20.
Blomstedt P, Sandvik U, Hariz MI, et al. Influence of age, gender and severity of tremor on outcome after thalamic and subthalamic DBS for essential tremor. Parkinsonism Relat Disord. 2011;17(8):617-20.
Blomstedt, P., Sandvik, U., Hariz, M. I., Fytagoridis, A., Forsgren, L., Hariz, G. M., & Koskinen, L. O. (2011). Influence of age, gender and severity of tremor on outcome after thalamic and subthalamic DBS for essential tremor. Parkinsonism & Related Disorders, 17(8), 617-20. https://doi.org/10.1016/j.parkreldis.2011.05.014
Blomstedt P, et al. Influence of Age, Gender and Severity of Tremor On Outcome After Thalamic and Subthalamic DBS for Essential Tremor. Parkinsonism Relat Disord. 2011;17(8):617-20. PubMed PMID: 21676643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of age, gender and severity of tremor on outcome after thalamic and subthalamic DBS for essential tremor. AU - Blomstedt,Patric, AU - Sandvik,Ulrika, AU - Hariz,Marwan I, AU - Fytagoridis,Anders, AU - Forsgren,Lars, AU - Hariz,Gun-Marie, AU - Koskinen,Lars-Owe D, Y1 - 2011/06/14/ PY - 2011/01/31/received PY - 2011/04/07/revised PY - 2011/05/17/accepted PY - 2011/6/17/entrez PY - 2011/6/17/pubmed PY - 2012/6/19/medline SP - 617 EP - 20 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 17 IS - 8 N2 - Deep brain stimulation (DBS) is an established treatment for essential tremor (ET). The nucleus ventralis intermedius thalami (Vim) is the target of choice, but promising results have been presented regarding DBS in the posterior subthalamic area (PSA). The aim of this study was to evaluate the possible influence of gender, age and severity of disease on the outcome of these procedures. Sixty eight patients (34 Vim, 34 PSA) with ET were included in this non-randomised study. Evaluation using the Essential Tremor Rating Scale (ETRS) was performed before, and one year after surgery concerning PSA DBS, and at a mean of 28 ± 24 months concerning Vim DBS. Items 5/6 and 11-14 (hand tremor and hand function) were selected for analysis of tremor outcome. The efficacy of DBS on essential tremor was not related to age or gender. Nor was it associated with the severity of tremor when the percentual reduction of tremor on stimulation was taken into account. However, patients with a more severe tremor at baseline had a higher degree of residual tremor on stimulation. Tremor in the treated hand and hand function were improved with 70% in the Vim group and 89% in the PSA group. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/21676643/Influence_of_age_gender_and_severity_of_tremor_on_outcome_after_thalamic_and_subthalamic_DBS_for_essential_tremor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(11)00146-5 DB - PRIME DP - Unbound Medicine ER -