Tags

Type your tag names separated by a space and hit enter

Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study.
Int J Cancer. 2012 May 01; 130(9):2204-10.IJ

Abstract

New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall and serous, mucinous, and endometroid histological subtypes, with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables. Altogether 836 incident EOC cases were identified among 326,831 women. The tumors were classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell, and 238 unspecified. Compared with never smokers, current smokers had a significantly increased risk for mucinous tumors [HR = 1.85 (95% CI 1.08-3.16)] and those smoking more than 10 cigarettes per day had a doubling in risk [HR = 2.25(95% CI 1.26-4.03)] as did those who had smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI 1.07-4.43)]. The results from the EPIC study add further evidence that smoking increases risk of mucinous ovarian cancer and support the notion that the effect of smoking varies according to histological subtype.

Authors+Show Affiliations

Institute of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. inger.gram@uit.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21678398

Citation

Gram, Inger T., et al. "Cigarette Smoking and Risk of Histological Subtypes of Epithelial Ovarian Cancer in the EPIC Cohort Study." International Journal of Cancer, vol. 130, no. 9, 2012, pp. 2204-10.
Gram IT, Lukanova A, Brill I, et al. Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study. Int J Cancer. 2012;130(9):2204-10.
Gram, I. T., Lukanova, A., Brill, I., Braaten, T., Lund, E., Lundin, E., Overvad, K., Tjønneland, A., Clavel-Chapelon, F., Chabbert-Buffet, N., Bamia, C., Trichopoulou, A., Zylis, D., Masala, G., Berrino, F., Galasso, R., Tumino, R., Sacerdote, C., Gavrilyuk, O., ... Kaaks, R. (2012). Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study. International Journal of Cancer, 130(9), 2204-10. https://doi.org/10.1002/ijc.26235
Gram IT, et al. Cigarette Smoking and Risk of Histological Subtypes of Epithelial Ovarian Cancer in the EPIC Cohort Study. Int J Cancer. 2012 May 1;130(9):2204-10. PubMed PMID: 21678398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study. AU - Gram,Inger T, AU - Lukanova,Annekatrin, AU - Brill,Ilene, AU - Braaten,Tonje, AU - Lund,Eiliv, AU - Lundin,Eva, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Clavel-Chapelon,Francoise, AU - Chabbert-Buffet,Nathalie, AU - Bamia,Christina, AU - Trichopoulou,Antonia, AU - Zylis,Dimosthenis, AU - Masala,Giovanna, AU - Berrino,Franco, AU - Galasso,Rocco, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Gavrilyuk,Oxana, AU - Kristiansen,Steinar, AU - Rodríguez,Laudina, AU - Bonet,Catalina, AU - Huerta,José María, AU - Barricarte,Aurelio, AU - Sánchez,Maria-José, AU - Dorronsoro,Miren, AU - Jirström,Karin, AU - Almquist,Martin, AU - Idahl,Annika, AU - Bueno-de-Mesquita,H Bas, AU - Braem,Marie, AU - Onland-Moret,Charlotte, AU - Tsilidis,Konstantinos K, AU - Allen,Naomi E, AU - Fedirko,Veronika, AU - Riboli,E, AU - Kaaks,Rudolf, Y1 - 2011/09/14/ PY - 2011/04/13/received PY - 2011/05/26/accepted PY - 2011/6/17/entrez PY - 2011/6/17/pubmed PY - 2012/5/16/medline SP - 2204 EP - 10 JF - International journal of cancer JO - Int. J. Cancer VL - 130 IS - 9 N2 - New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall and serous, mucinous, and endometroid histological subtypes, with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables. Altogether 836 incident EOC cases were identified among 326,831 women. The tumors were classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell, and 238 unspecified. Compared with never smokers, current smokers had a significantly increased risk for mucinous tumors [HR = 1.85 (95% CI 1.08-3.16)] and those smoking more than 10 cigarettes per day had a doubling in risk [HR = 2.25(95% CI 1.26-4.03)] as did those who had smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI 1.07-4.43)]. The results from the EPIC study add further evidence that smoking increases risk of mucinous ovarian cancer and support the notion that the effect of smoking varies according to histological subtype. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21678398/Cigarette_smoking_and_risk_of_histological_subtypes_of_epithelial_ovarian_cancer_in_the_EPIC_cohort_study_ L2 - https://doi.org/10.1002/ijc.26235 DB - PRIME DP - Unbound Medicine ER -