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Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome.
Aliment Pharmacol Ther 2011; 34(4):432-42AP

Abstract

BACKGROUND

Otilonium bromide (OB) is a spasmolytic agent that blocks L-Type Calcium channels in human colonic smooth muscle.

AIM

To study the efficacy of OB in symptom control in irritable bowel syndrome (IBS).

METHODS

A total of 356 patients (46.16±19years, 71% female) with IBS participated in a double-blind, randomised, parallel placebo-controlled phase IV study. OB (40mg t.d.s.) or placebo was administered for 15weeks, and follow-up was extended 10 additional weeks.

RESULTS

Otilonium bromide (n=179) and placebo (n=177) groups had comparable demographics, symptom severity and IBS subtype. Both OB and placebo reduced abdominal pain and IBS symptoms. The effect of OB was significantly greater than placebo in the reduction of weekly frequency of episodes of abdominal pain at the end of treatment period (primary endpoint, -0.90±0.88 vs. -0.65±0.91, P=0.03), reduction of abdominal bloating (-1.2±1.2 vs. -0.9±1.1, P=0.02) and global efficacy by patient assessment (1.3±1.1 vs. 1.0±1.1, P=0.047). Intensity of abdominal pain, proportion of patient responders, safety and quality of life scores were similarly affected by OB and placebo. During follow-up, the therapeutic effect of OB remained greater than placebo in terms of withdrawal rate due to symptom relapse (10% vs. 27%, P=0.009), global efficacy of treatment and relapse-free probability (P=0.038).

CONCLUSIONS

This placebo-controlled double-blind study shows that otilonium bromide is safe, well tolerated and superior to placebo in reducing the frequency of abdominal pain, severity of abdominal bloating and protecting from symptom relapse in IBS. These results further confirm that patients with IBS can improve during and following treatment with otilonium bromide.

Authors+Show Affiliations

Department of Surgery, Hospital de Mataró, Universitat Autònoma de Barcelona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21679214

Citation

Clavé, P, et al. "Randomised Clinical Trial: Otilonium Bromide Improves Frequency of Abdominal Pain, Severity of Distention and Time to Relapse in Patients With Irritable Bowel Syndrome." Alimentary Pharmacology & Therapeutics, vol. 34, no. 4, 2011, pp. 432-42.
Clavé P, Acalovschi M, Triantafillidis JK, et al. Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2011;34(4):432-42.
Clavé, P., Acalovschi, M., Triantafillidis, J. K., Uspensky, Y. P., Kalayci, C., Shee, V., & Tack, J. (2011). Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 34(4), pp. 432-42. doi:10.1111/j.1365-2036.2011.04730.x.
Clavé P, et al. Randomised Clinical Trial: Otilonium Bromide Improves Frequency of Abdominal Pain, Severity of Distention and Time to Relapse in Patients With Irritable Bowel Syndrome. Aliment Pharmacol Ther. 2011;34(4):432-42. PubMed PMID: 21679214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome. AU - Clavé,P, AU - Acalovschi,M, AU - Triantafillidis,J K, AU - Uspensky,Y P, AU - Kalayci,C, AU - Shee,V, AU - Tack,J, AU - ,, Y1 - 2011/06/16/ PY - 2011/6/18/entrez PY - 2011/6/18/pubmed PY - 2011/10/18/medline SP - 432 EP - 42 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 34 IS - 4 N2 - BACKGROUND: Otilonium bromide (OB) is a spasmolytic agent that blocks L-Type Calcium channels in human colonic smooth muscle. AIM: To study the efficacy of OB in symptom control in irritable bowel syndrome (IBS). METHODS: A total of 356 patients (46.16±19years, 71% female) with IBS participated in a double-blind, randomised, parallel placebo-controlled phase IV study. OB (40mg t.d.s.) or placebo was administered for 15weeks, and follow-up was extended 10 additional weeks. RESULTS: Otilonium bromide (n=179) and placebo (n=177) groups had comparable demographics, symptom severity and IBS subtype. Both OB and placebo reduced abdominal pain and IBS symptoms. The effect of OB was significantly greater than placebo in the reduction of weekly frequency of episodes of abdominal pain at the end of treatment period (primary endpoint, -0.90±0.88 vs. -0.65±0.91, P=0.03), reduction of abdominal bloating (-1.2±1.2 vs. -0.9±1.1, P=0.02) and global efficacy by patient assessment (1.3±1.1 vs. 1.0±1.1, P=0.047). Intensity of abdominal pain, proportion of patient responders, safety and quality of life scores were similarly affected by OB and placebo. During follow-up, the therapeutic effect of OB remained greater than placebo in terms of withdrawal rate due to symptom relapse (10% vs. 27%, P=0.009), global efficacy of treatment and relapse-free probability (P=0.038). CONCLUSIONS: This placebo-controlled double-blind study shows that otilonium bromide is safe, well tolerated and superior to placebo in reducing the frequency of abdominal pain, severity of abdominal bloating and protecting from symptom relapse in IBS. These results further confirm that patients with IBS can improve during and following treatment with otilonium bromide. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/21679214/Randomised_clinical_trial:_otilonium_bromide_improves_frequency_of_abdominal_pain_severity_of_distention_and_time_to_relapse_in_patients_with_irritable_bowel_syndrome_ L2 - https://doi.org/10.1111/j.1365-2036.2011.04730.x DB - PRIME DP - Unbound Medicine ER -