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ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection.
Cancer Epidemiol Biomarkers Prev. 2011 Aug; 20(8):1665-72.CE

Abstract

BACKGROUND

Although several studies have investigated the association between ABO blood type and risk of gastric cancer (GC), atrophic gastritis (AG), and Helicobacter pylori (HP) infection, no study has investigated these associations by using ABO genotype.

METHODS

We conducted a case-control study in 703 patients with GC and 1,465 noncancer patients. We also conducted a cross-sectional study by using 1,406 of these 1,465 controls, who were examined for pepsinogens and anti-HP IgG antibody levels in serum. ABO genotype was determined from single nucleotide polymorphisms in ABO gene. We used rs8176719 to mark the O allele, and rs8176746 and rs8176747 to mark the B allele. ORs and 95% CIs were calculated by a multivariate logistic model.

RESULTS

We observed significant associations between ABO genotype and GC, AG, and HP infection. ORs (95% CIs) of GC were 0.70 (0.50-0.99) for OO and 0.53 (0.36-0.77) for BO relative to AA genotype. An increased risk of GC was observed with addition of the A allele (P(trend) < 0.001), and a decreased risk with that of the B allele (P(trend) = 0.023). An OR of AG was 0.73 (95% CI, 0.53-0.99) for blood type B relative to blood type A, and an OR of HP infection was 0.39 (95% CI, 0.17-0.87) for BB relative to AA genotype.

CONCLUSION

This study identified a statistically significant association between ABO genotype and GC risk. In addition, ABO gene locus may influence AG prevalence and HP infection.

IMPACT

Further studies are necessary to confirm these findings.

Authors+Show Affiliations

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21680535

Citation

Nakao, Makoto, et al. "ABO Genotype and the Risk of Gastric Cancer, Atrophic Gastritis, and Helicobacter Pylori Infection." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 20, no. 8, 2011, pp. 1665-72.
Nakao M, Matsuo K, Ito H, et al. ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection. Cancer Epidemiol Biomarkers Prev. 2011;20(8):1665-72.
Nakao, M., Matsuo, K., Ito, H., Shitara, K., Hosono, S., Watanabe, M., Ito, S., Sawaki, A., Iida, S., Sato, S., Yatabe, Y., Yamao, K., Ueda, R., Tajima, K., Hamajima, N., & Tanaka, H. (2011). ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 20(8), 1665-72. https://doi.org/10.1158/1055-9965.EPI-11-0213
Nakao M, et al. ABO Genotype and the Risk of Gastric Cancer, Atrophic Gastritis, and Helicobacter Pylori Infection. Cancer Epidemiol Biomarkers Prev. 2011;20(8):1665-72. PubMed PMID: 21680535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection. AU - Nakao,Makoto, AU - Matsuo,Keitaro, AU - Ito,Hidemi, AU - Shitara,Kohei, AU - Hosono,Satoyo, AU - Watanabe,Miki, AU - Ito,Seiji, AU - Sawaki,Akira, AU - Iida,Shinsuke, AU - Sato,Shigeki, AU - Yatabe,Yasushi, AU - Yamao,Kenji, AU - Ueda,Ryuzo, AU - Tajima,Kazuo, AU - Hamajima,Nobuyuki, AU - Tanaka,Hideo, Y1 - 2011/06/15/ PY - 2011/6/18/entrez PY - 2011/6/18/pubmed PY - 2012/2/2/medline SP - 1665 EP - 72 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 20 IS - 8 N2 - BACKGROUND: Although several studies have investigated the association between ABO blood type and risk of gastric cancer (GC), atrophic gastritis (AG), and Helicobacter pylori (HP) infection, no study has investigated these associations by using ABO genotype. METHODS: We conducted a case-control study in 703 patients with GC and 1,465 noncancer patients. We also conducted a cross-sectional study by using 1,406 of these 1,465 controls, who were examined for pepsinogens and anti-HP IgG antibody levels in serum. ABO genotype was determined from single nucleotide polymorphisms in ABO gene. We used rs8176719 to mark the O allele, and rs8176746 and rs8176747 to mark the B allele. ORs and 95% CIs were calculated by a multivariate logistic model. RESULTS: We observed significant associations between ABO genotype and GC, AG, and HP infection. ORs (95% CIs) of GC were 0.70 (0.50-0.99) for OO and 0.53 (0.36-0.77) for BO relative to AA genotype. An increased risk of GC was observed with addition of the A allele (P(trend) < 0.001), and a decreased risk with that of the B allele (P(trend) = 0.023). An OR of AG was 0.73 (95% CI, 0.53-0.99) for blood type B relative to blood type A, and an OR of HP infection was 0.39 (95% CI, 0.17-0.87) for BB relative to AA genotype. CONCLUSION: This study identified a statistically significant association between ABO genotype and GC risk. In addition, ABO gene locus may influence AG prevalence and HP infection. IMPACT: Further studies are necessary to confirm these findings. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/21680535/ABO_genotype_and_the_risk_of_gastric_cancer_atrophic_gastritis_and_Helicobacter_pylori_infection_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=21680535 DB - PRIME DP - Unbound Medicine ER -