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Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10.
J Sports Med Phys Fitness. 2011 Jun; 51(2):305-12.JS

Abstract

AIM

The purpose was to determine the changes of oxidative stress and antioxidant markers in plasma after repeated bouts of supramaximal exercise and the effects of coenzyme Q10 supplementation on these changes.

METHODS

This randomized, double blind, crossover study was composed of two 8-week periods of supplementation with either 100 mg.day(-1) CoQ10 or placebo. Fifteen healthy and sedentary men participated in the study. Five Wingate tests with 2 min rest between tests were performed. Blood samples were collected at rest, immediately after, 15 and 60 min after the fifth Wingate test for oxidative stress (malondialdehyde, nitric oxide, xanthine oxidase and adenosine deaminase) and antioxidant (superoxide dismutase, glutathione peroxidase and uric acid) markers.

RESULTS

At baseline exercise session, malondialdehyde increased 15 and 60 min after the exercise compared to the rest and immediately after the exercise. Malondialdehyde at rest, immediately after and 60 min after the exercise decreased with coenzyme Q10 supplementation when compared to baseline. At baseline exercise session, uric acid increased 15 and 60 min after the exercise when compared to the rest. In conclusion, lipid peroxidation and antioxidant defense increase after repeated short-term supramaximal exercise.

CONCLUSION

Coenzyme Q10 supplementation partially prevents the increase in lipid peroxidation after repeated short-term supramaximal exercise.

Authors+Show Affiliations

Department of Physiology, Meram Faculty of Medicine, Selçuk University, Konya, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21681167

Citation

Gül, I, et al. "Oxidative Stress and Antioxidant Defense in Plasma After Repeated Bouts of Supramaximal Exercise: the Effect of Coenzyme Q10." The Journal of Sports Medicine and Physical Fitness, vol. 51, no. 2, 2011, pp. 305-12.
Gül I, Gökbel H, Belviranli M, et al. Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10. J Sports Med Phys Fitness. 2011;51(2):305-12.
Gül, I., Gökbel, H., Belviranli, M., Okudan, N., Büyükbaş, S., & Başarali, K. (2011). Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10. The Journal of Sports Medicine and Physical Fitness, 51(2), 305-12.
Gül I, et al. Oxidative Stress and Antioxidant Defense in Plasma After Repeated Bouts of Supramaximal Exercise: the Effect of Coenzyme Q10. J Sports Med Phys Fitness. 2011;51(2):305-12. PubMed PMID: 21681167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10. AU - Gül,I, AU - Gökbel,H, AU - Belviranli,M, AU - Okudan,N, AU - Büyükbaş,S, AU - Başarali,K, PY - 2011/6/18/entrez PY - 2011/6/18/pubmed PY - 2011/11/4/medline SP - 305 EP - 12 JF - The Journal of sports medicine and physical fitness JO - J Sports Med Phys Fitness VL - 51 IS - 2 N2 - AIM: The purpose was to determine the changes of oxidative stress and antioxidant markers in plasma after repeated bouts of supramaximal exercise and the effects of coenzyme Q10 supplementation on these changes. METHODS: This randomized, double blind, crossover study was composed of two 8-week periods of supplementation with either 100 mg.day(-1) CoQ10 or placebo. Fifteen healthy and sedentary men participated in the study. Five Wingate tests with 2 min rest between tests were performed. Blood samples were collected at rest, immediately after, 15 and 60 min after the fifth Wingate test for oxidative stress (malondialdehyde, nitric oxide, xanthine oxidase and adenosine deaminase) and antioxidant (superoxide dismutase, glutathione peroxidase and uric acid) markers. RESULTS: At baseline exercise session, malondialdehyde increased 15 and 60 min after the exercise compared to the rest and immediately after the exercise. Malondialdehyde at rest, immediately after and 60 min after the exercise decreased with coenzyme Q10 supplementation when compared to baseline. At baseline exercise session, uric acid increased 15 and 60 min after the exercise when compared to the rest. In conclusion, lipid peroxidation and antioxidant defense increase after repeated short-term supramaximal exercise. CONCLUSION: Coenzyme Q10 supplementation partially prevents the increase in lipid peroxidation after repeated short-term supramaximal exercise. SN - 0022-4707 UR - https://www.unboundmedicine.com/medline/citation/21681167/Oxidative_stress_and_antioxidant_defense_in_plasma_after_repeated_bouts_of_supramaximal_exercise:_the_effect_of_coenzyme_Q10_ L2 - http://www.minervamedica.it/index2.t?show=R40Y2011N02A0305 DB - PRIME DP - Unbound Medicine ER -