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[Calciphylaxis. Pathogenesis and therapy].
Hautarzt 2011; 62(7):509-15H

Abstract

Calciphylaxis is a rare disease associated with thrombotic cutaneous ischemia and necrosis. Lesions are usually located on the lower extremities, buttocks and the abdomen. Calciphylaxis is recognized by medial calcification, inflammation and subintimal fibrosis of cutaneous arterioles. Calcification, thrombus formation and occlusion occur sequential before tissue necrosis. The disease is usually observed in patients with end-stage renal disease and hyperparathyroidism. In end-stage renal disease, an elevated parathyroid hormone level, hypercalcemia and hyperphosphatemia direct to vascular mineralization. Calciphylaxis affects about 4% of hemodialysis patients. The clinical syndrome is characterized by a high mortality rate. The most important measure is an active multidisciplinary management approach, with intention to wound care and prevention of sepsis.

Authors+Show Affiliations

Hautklinik, Heinrich-Heine-Universität, Moorenstr. 5, 40225, Düsseldorf, Deutschland.No affiliation info available

Pub Type(s)

Journal Article

Language

ger

PubMed ID

21681545

Citation

Hoff, N-P, and B Homey. "[Calciphylaxis. Pathogenesis and Therapy]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 62, no. 7, 2011, pp. 509-15.
Hoff NP, Homey B. [Calciphylaxis. Pathogenesis and therapy]. Hautarzt. 2011;62(7):509-15.
Hoff, N. P., & Homey, B. (2011). [Calciphylaxis. Pathogenesis and therapy]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 62(7), pp. 509-15. doi:10.1007/s00105-010-2111-8.
Hoff NP, Homey B. [Calciphylaxis. Pathogenesis and Therapy]. Hautarzt. 2011;62(7):509-15. PubMed PMID: 21681545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Calciphylaxis. Pathogenesis and therapy]. AU - Hoff,N-P, AU - Homey,B, PY - 2011/6/18/entrez PY - 2011/6/18/pubmed PY - 2012/1/12/medline SP - 509 EP - 15 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 62 IS - 7 N2 - Calciphylaxis is a rare disease associated with thrombotic cutaneous ischemia and necrosis. Lesions are usually located on the lower extremities, buttocks and the abdomen. Calciphylaxis is recognized by medial calcification, inflammation and subintimal fibrosis of cutaneous arterioles. Calcification, thrombus formation and occlusion occur sequential before tissue necrosis. The disease is usually observed in patients with end-stage renal disease and hyperparathyroidism. In end-stage renal disease, an elevated parathyroid hormone level, hypercalcemia and hyperphosphatemia direct to vascular mineralization. Calciphylaxis affects about 4% of hemodialysis patients. The clinical syndrome is characterized by a high mortality rate. The most important measure is an active multidisciplinary management approach, with intention to wound care and prevention of sepsis. SN - 1432-1173 UR - https://www.unboundmedicine.com/medline/citation/21681545/[Calciphylaxis__Pathogenesis_and_therapy]_ L2 - https://dx.doi.org/10.1007/s00105-010-2111-8 DB - PRIME DP - Unbound Medicine ER -