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A meta-analysis of fat intake, reproduction, and breast cancer risk: an evolutionary perspective.

Abstract

OBJECTIVES

This study is a systematic review of literature published up to May of 2010 aimed to identify relationships between dietary fat, and fat subtypes, with risk of breast cancer in women.

METHODS

Descriptive data, estimates of relative risk and associated 95% confidence interval (CI) were extracted from relative studies and analyzed using the random effects model of DerSimonian and Laird.

RESULTS

Cohort study results indicated significant summary relative risks between polyunsaturated fat and breast cancer (1.091, 95% CI: 1.001; 1.184). In case-control studies no association between fat and breast cancer was observed. Post-menopausal women indicated a significant association between total fat (1.042, 95%CI: 1.013; 1.073), PUFA intake (1.22, 95% CI: 1.08; 1.381), and breast cancer. A non-significant inverse relation between intake of all fat types and breast cancer was identified in premenopausal women.

CONCLUSIONS

These results support the idea that possible elevations in serum estrogen levels by an adult exposure to a high-fat diet would increase breast cancer risk. Furthermore, menopausal status was observed to affect women's risk of breast cancer. Higher risks of breast cancer were found in post-menopausal women consuming diets high in total fat and polyunsaturated fats. Conversely, dietary fat appears to have preventative effects in pre-menopausal women. This study takes a transformative approach combining epidemiological, biomedical, and evolutionary theory to evaluate how biocultural variations in risk factors (i.e., diet and reproduction) affect the evolution of breast cancers.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Anthropology, Indiana University, Bloomington, Indiana 47405, USA. turnerlb@indiana.edu

    Source

    MeSH

    Adult
    Biological Evolution
    Breast Neoplasms
    Case-Control Studies
    Cohort Studies
    Dietary Fats
    Female
    Humans
    Middle Aged
    Postmenopause
    Premenopause
    Reproduction
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    21681848

    Citation

    Turner, Laurah B.. "A Meta-analysis of Fat Intake, Reproduction, and Breast Cancer Risk: an Evolutionary Perspective." American Journal of Human Biology : the Official Journal of the Human Biology Council, vol. 23, no. 5, 2011, pp. 601-8.
    Turner LB. A meta-analysis of fat intake, reproduction, and breast cancer risk: an evolutionary perspective. Am J Hum Biol. 2011;23(5):601-8.
    Turner, L. B. (2011). A meta-analysis of fat intake, reproduction, and breast cancer risk: an evolutionary perspective. American Journal of Human Biology : the Official Journal of the Human Biology Council, 23(5), pp. 601-8. doi:10.1002/ajhb.21176.
    Turner LB. A Meta-analysis of Fat Intake, Reproduction, and Breast Cancer Risk: an Evolutionary Perspective. Am J Hum Biol. 2011;23(5):601-8. PubMed PMID: 21681848.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A meta-analysis of fat intake, reproduction, and breast cancer risk: an evolutionary perspective. A1 - Turner,Laurah B, Y1 - 2011/06/16/ PY - 2010/11/04/received PY - 2011/03/08/accepted PY - 2011/6/18/entrez PY - 2011/6/18/pubmed PY - 2011/12/14/medline SP - 601 EP - 8 JF - American journal of human biology : the official journal of the Human Biology Council JO - Am. J. Hum. Biol. VL - 23 IS - 5 N2 - OBJECTIVES: This study is a systematic review of literature published up to May of 2010 aimed to identify relationships between dietary fat, and fat subtypes, with risk of breast cancer in women. METHODS: Descriptive data, estimates of relative risk and associated 95% confidence interval (CI) were extracted from relative studies and analyzed using the random effects model of DerSimonian and Laird. RESULTS: Cohort study results indicated significant summary relative risks between polyunsaturated fat and breast cancer (1.091, 95% CI: 1.001; 1.184). In case-control studies no association between fat and breast cancer was observed. Post-menopausal women indicated a significant association between total fat (1.042, 95%CI: 1.013; 1.073), PUFA intake (1.22, 95% CI: 1.08; 1.381), and breast cancer. A non-significant inverse relation between intake of all fat types and breast cancer was identified in premenopausal women. CONCLUSIONS: These results support the idea that possible elevations in serum estrogen levels by an adult exposure to a high-fat diet would increase breast cancer risk. Furthermore, menopausal status was observed to affect women's risk of breast cancer. Higher risks of breast cancer were found in post-menopausal women consuming diets high in total fat and polyunsaturated fats. Conversely, dietary fat appears to have preventative effects in pre-menopausal women. This study takes a transformative approach combining epidemiological, biomedical, and evolutionary theory to evaluate how biocultural variations in risk factors (i.e., diet and reproduction) affect the evolution of breast cancers. SN - 1520-6300 UR - https://www.unboundmedicine.com/medline/citation/21681848/A_meta_analysis_of_fat_intake_reproduction_and_breast_cancer_risk:_an_evolutionary_perspective_ L2 - https://doi.org/10.1002/ajhb.21176 DB - PRIME DP - Unbound Medicine ER -