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Neutrophil myeloperoxidase measurement uncovers masked megaloblastic anemia.
Blood. 1990 Sep 01; 76(5):1004-7.Blood

Abstract

We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean cell volume (MCV) and five without macrocytosis. Regardless of the MCV, our megaloblastic patients had hypersegmented neutrophils and elevated MPXI levels without visible alteration of granule content. MPXI measurement may be particularly useful in identifying cases of "masked megaloblastic anemia" where the MCV is below 100 fL. The advantage of the MPXI over other methods of uncovering masked megaloblastic anemia is its simplicity when performed as part of a routine complete blood count on an automated hematology instrument.

Authors+Show Affiliations

Department of Pathology, University of North Carolina School of Medicine, Chapel Hill 27599.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2168223

Citation

Gulley, M L., et al. "Neutrophil Myeloperoxidase Measurement Uncovers Masked Megaloblastic Anemia." Blood, vol. 76, no. 5, 1990, pp. 1004-7.
Gulley ML, Bentley SA, Ross DW. Neutrophil myeloperoxidase measurement uncovers masked megaloblastic anemia. Blood. 1990;76(5):1004-7.
Gulley, M. L., Bentley, S. A., & Ross, D. W. (1990). Neutrophil myeloperoxidase measurement uncovers masked megaloblastic anemia. Blood, 76(5), 1004-7.
Gulley ML, Bentley SA, Ross DW. Neutrophil Myeloperoxidase Measurement Uncovers Masked Megaloblastic Anemia. Blood. 1990 Sep 1;76(5):1004-7. PubMed PMID: 2168223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutrophil myeloperoxidase measurement uncovers masked megaloblastic anemia. AU - Gulley,M L, AU - Bentley,S A, AU - Ross,D W, PY - 1990/9/1/pubmed PY - 1990/9/1/medline PY - 1990/9/1/entrez SP - 1004 EP - 7 JF - Blood JO - Blood VL - 76 IS - 5 N2 - We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean cell volume (MCV) and five without macrocytosis. Regardless of the MCV, our megaloblastic patients had hypersegmented neutrophils and elevated MPXI levels without visible alteration of granule content. MPXI measurement may be particularly useful in identifying cases of "masked megaloblastic anemia" where the MCV is below 100 fL. The advantage of the MPXI over other methods of uncovering masked megaloblastic anemia is its simplicity when performed as part of a routine complete blood count on an automated hematology instrument. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/2168223/Neutrophil_myeloperoxidase_measurement_uncovers_masked_megaloblastic_anemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-4971(20)74503-9 DB - PRIME DP - Unbound Medicine ER -