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Comminution of ibuprofen to produce nano-particles for rapid dissolution.
Int J Pharm. 2011 Aug 30; 415(1-2):307-14.IJ

Abstract

A critical problem associated with poorly soluble drugs is low and variable bioavailability derived from slow dissolution and erratic absorption. The preparation of nano-formulations has been identified as an approach to enhance the rate and extent of drug absorption for compounds demonstrating limited aqueous solubility. A new technology for the production of nano-particles using high speed, high efficiency processes that can rapidly generate nano-particles with rapid dissolution rate has been developed. Size reduction of a low melting ductile model compound was achieved in periods less than 1h. Particle size reduction of ibuprofen using this methodology resulted in production of crystalline particles with average diameter of approximately 270nm. Physical stability studies showed that the nano-suspension remained homogeneous with slight increases in mean particle size, when stored at room temperature and under refrigerated storage conditions 2-8°C for up to 2 days. Powder containing crystalline drug was prepared by spray-drying ibuprofen nano-suspensions with mannitol dissolved in the aqueous phase. Dissolution studies showed similar release rates for the nano-suspension and powder which were markedly improved compared to a commercially available drug product. Ibuprofen nano-particles could be produced rapidly with smaller sizes achieved at higher suspension concentrations. Particles produced in water with stabilisers demonstrated greatest physical stability, whilst rapid dissolution was observed for the nano-particles isolated in powder form.

Authors+Show Affiliations

Lena Nanoceutics Ltd., Institute of Pharmaceutical Innovation, Bradford BD7 1DP, UK. splakkot@brad.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21683776

Citation

Plakkot, S, et al. "Comminution of Ibuprofen to Produce Nano-particles for Rapid Dissolution." International Journal of Pharmaceutics, vol. 415, no. 1-2, 2011, pp. 307-14.
Plakkot S, de Matas M, York P, et al. Comminution of ibuprofen to produce nano-particles for rapid dissolution. Int J Pharm. 2011;415(1-2):307-14.
Plakkot, S., de Matas, M., York, P., Saunders, M., & Sulaiman, B. (2011). Comminution of ibuprofen to produce nano-particles for rapid dissolution. International Journal of Pharmaceutics, 415(1-2), 307-14. https://doi.org/10.1016/j.ijpharm.2011.06.002
Plakkot S, et al. Comminution of Ibuprofen to Produce Nano-particles for Rapid Dissolution. Int J Pharm. 2011 Aug 30;415(1-2):307-14. PubMed PMID: 21683776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comminution of ibuprofen to produce nano-particles for rapid dissolution. AU - Plakkot,S, AU - de Matas,M, AU - York,P, AU - Saunders,M, AU - Sulaiman,B, Y1 - 2011/06/12/ PY - 2011/02/16/received PY - 2011/05/31/revised PY - 2011/06/01/accepted PY - 2011/6/21/entrez PY - 2011/6/21/pubmed PY - 2011/12/13/medline SP - 307 EP - 14 JF - International journal of pharmaceutics JO - Int J Pharm VL - 415 IS - 1-2 N2 - A critical problem associated with poorly soluble drugs is low and variable bioavailability derived from slow dissolution and erratic absorption. The preparation of nano-formulations has been identified as an approach to enhance the rate and extent of drug absorption for compounds demonstrating limited aqueous solubility. A new technology for the production of nano-particles using high speed, high efficiency processes that can rapidly generate nano-particles with rapid dissolution rate has been developed. Size reduction of a low melting ductile model compound was achieved in periods less than 1h. Particle size reduction of ibuprofen using this methodology resulted in production of crystalline particles with average diameter of approximately 270nm. Physical stability studies showed that the nano-suspension remained homogeneous with slight increases in mean particle size, when stored at room temperature and under refrigerated storage conditions 2-8°C for up to 2 days. Powder containing crystalline drug was prepared by spray-drying ibuprofen nano-suspensions with mannitol dissolved in the aqueous phase. Dissolution studies showed similar release rates for the nano-suspension and powder which were markedly improved compared to a commercially available drug product. Ibuprofen nano-particles could be produced rapidly with smaller sizes achieved at higher suspension concentrations. Particles produced in water with stabilisers demonstrated greatest physical stability, whilst rapid dissolution was observed for the nano-particles isolated in powder form. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/21683776/Comminution_of_ibuprofen_to_produce_nano_particles_for_rapid_dissolution_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(11)00533-3 DB - PRIME DP - Unbound Medicine ER -