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Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases.
Ann Diagn Pathol. 2011 Oct; 15(5):338-41.AD

Abstract

Immunohistochemical studies of atypical polypoid adenomyoma (APA) of the uterus are very rare. Five cases of APA were retrieved from the surgical cases of our laboratory. The ages were 38, 41, 54, 65, and 77 years (mean ± SD, 55 ± 14.6 years). The diameters of APA were 1.2, 1.9, 2.3, 3.2, and 7.0 cm (mean ± SD, 3.12 ± 2.00 cm). Histologically, APA consisted of complex glandular element and mesenchymal fibromuscular element. No endometrial stroma was present. Mucins were found in the glands but not in the mesenchyma. The glands were consistently positive for pancytokeratin (AE1/3, CAM5.2), cytokeratin (CK) 7, CK8, CK18, CK19, vimentin, CA125, estrogen receptor, progesterone receptor, MUC1, and MUC6. The glands were consistently negative for CK14, CK20, CEA, epithelial membrane antigen, S100 protein, p53, CD10, MUC2, and MUC5AC. Some cases were positive for CK34βE12 (4/5), CK5/6 (4/5), and CA19-9 (4/5). The Ki-67 labeling ranged from 3% to 10%. The mesenchymal element was consistently positive for vimentin, α-smooth muscle actin, estrogen receptor, progesterone receptor, and CD10, while consistently negative for pancytokeratin (AE1/3, CAM5.2), CK34βE12, CK5/6, CK7, CK8, CK14, CK18, CK19, CK20, CEA, epithelial membrane antigen, S100 protein, CA125, CA19-9, p53, MUC1, MUC2, MUC5AC, and MUC6. Some cases were positive for desmin (2/5). Ki-67 labeling ranged from 1% to 8%. In conclusion, the immunoprofile of APA was reported. The findings provide basic knowledge of APA of the uterus.

Authors+Show Affiliations

Departments of Pathology, Shizuoka City Shimizu Hospital, Japan. piyo0111jp@yahoo.co.jp

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21684185

Citation

Terada, Tadashi. "Atypical Polypoid Adenomyoma of the Uterus: an Immunohistochemical Study On 5 Cases." Annals of Diagnostic Pathology, vol. 15, no. 5, 2011, pp. 338-41.
Terada T. Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases. Ann Diagn Pathol. 2011;15(5):338-41.
Terada, T. (2011). Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases. Annals of Diagnostic Pathology, 15(5), 338-41. https://doi.org/10.1016/j.anndiagpath.2011.03.008
Terada T. Atypical Polypoid Adenomyoma of the Uterus: an Immunohistochemical Study On 5 Cases. Ann Diagn Pathol. 2011;15(5):338-41. PubMed PMID: 21684185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases. A1 - Terada,Tadashi, Y1 - 2011/06/17/ PY - 2011/02/11/received PY - 2011/03/06/revised PY - 2011/03/30/accepted PY - 2011/6/21/entrez PY - 2011/6/21/pubmed PY - 2011/12/14/medline SP - 338 EP - 41 JF - Annals of diagnostic pathology JO - Ann Diagn Pathol VL - 15 IS - 5 N2 - Immunohistochemical studies of atypical polypoid adenomyoma (APA) of the uterus are very rare. Five cases of APA were retrieved from the surgical cases of our laboratory. The ages were 38, 41, 54, 65, and 77 years (mean ± SD, 55 ± 14.6 years). The diameters of APA were 1.2, 1.9, 2.3, 3.2, and 7.0 cm (mean ± SD, 3.12 ± 2.00 cm). Histologically, APA consisted of complex glandular element and mesenchymal fibromuscular element. No endometrial stroma was present. Mucins were found in the glands but not in the mesenchyma. The glands were consistently positive for pancytokeratin (AE1/3, CAM5.2), cytokeratin (CK) 7, CK8, CK18, CK19, vimentin, CA125, estrogen receptor, progesterone receptor, MUC1, and MUC6. The glands were consistently negative for CK14, CK20, CEA, epithelial membrane antigen, S100 protein, p53, CD10, MUC2, and MUC5AC. Some cases were positive for CK34βE12 (4/5), CK5/6 (4/5), and CA19-9 (4/5). The Ki-67 labeling ranged from 3% to 10%. The mesenchymal element was consistently positive for vimentin, α-smooth muscle actin, estrogen receptor, progesterone receptor, and CD10, while consistently negative for pancytokeratin (AE1/3, CAM5.2), CK34βE12, CK5/6, CK7, CK8, CK14, CK18, CK19, CK20, CEA, epithelial membrane antigen, S100 protein, CA125, CA19-9, p53, MUC1, MUC2, MUC5AC, and MUC6. Some cases were positive for desmin (2/5). Ki-67 labeling ranged from 1% to 8%. In conclusion, the immunoprofile of APA was reported. The findings provide basic knowledge of APA of the uterus. SN - 1532-8198 UR - https://www.unboundmedicine.com/medline/citation/21684185/Atypical_polypoid_adenomyoma_of_the_uterus:_an_immunohistochemical_study_on_5_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1092-9134(11)00057-8 DB - PRIME DP - Unbound Medicine ER -