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Pancreatic cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health Study.

Abstract

Nitrate and nitrite are precursors of N-nitroso compounds, which induce tumors of the pancreas in animals. The authors evaluated the relation of dietary nitrate and nitrite to pancreatic cancer risk in the NIH-AARP Diet and Health Study. Nitrate and nitrite intakes were assessed at baseline using a 124-item food frequency questionnaire. During approximately 10 years of follow-up between 1995 and 2006, 1,728 incident pancreatic cancer cases were identified. There was no association between total nitrate or nitrite intake and pancreatic cancer in men or women. However, men in the highest quintile of summed nitrate/nitrite intake from processed meat had a nonsignificantly elevated risk of pancreatic cancer (hazard ratio = 1.18, 95% confidence interval: 0.95, 1.47; P-trend = 0.11). The authors observed a stronger increase in risk among men for nitrate/nitrite intake from processed meat at ages 12-13 years (highest quintile vs. lowest: hazard ratio = 1.32, 95% confidence interval: 0.99, 1.76; P-trend = 0.11), though the relation did not achieve statistical significance. The authors found no associations between adult or adolescent nitrate or nitrite intake from processed meats and pancreatic cancer among women. These results provide modest evidence that processed meat sources of dietary nitrate and nitrite may be associated with pancreatic cancer among men and provide no support for the hypothesis in women.

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  • Authors+Show Affiliations

    ,

    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA. kilfoyb@mail.nih.gov

    , , , , ,

    Source

    American journal of epidemiology 174:3 2011 Aug 01 pg 305-15

    MeSH

    Aged
    Confidence Intervals
    Diet
    Diet Surveys
    Humans
    Male
    Meat Products
    Middle Aged
    Multivariate Analysis
    Nitrates
    Nitrites
    Pancreatic Neoplasms
    Proportional Hazards Models
    Risk Factors
    Sex Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    21685410

    Citation

    Aschebrook-Kilfoy, Briseis, et al. "Pancreatic Cancer and Exposure to Dietary Nitrate and Nitrite in the NIH-AARP Diet and Health Study." American Journal of Epidemiology, vol. 174, no. 3, 2011, pp. 305-15.
    Aschebrook-Kilfoy B, Cross AJ, Stolzenberg-Solomon RZ, et al. Pancreatic cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health Study. Am J Epidemiol. 2011;174(3):305-15.
    Aschebrook-Kilfoy, B., Cross, A. J., Stolzenberg-Solomon, R. Z., Schatzkin, A., Hollenbeck, A. R., Sinha, R., & Ward, M. H. (2011). Pancreatic cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health Study. American Journal of Epidemiology, 174(3), pp. 305-15. doi:10.1093/aje/kwr092.
    Aschebrook-Kilfoy B, et al. Pancreatic Cancer and Exposure to Dietary Nitrate and Nitrite in the NIH-AARP Diet and Health Study. Am J Epidemiol. 2011 Aug 1;174(3):305-15. PubMed PMID: 21685410.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pancreatic cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health Study. AU - Aschebrook-Kilfoy,Briseis, AU - Cross,Amanda J, AU - Stolzenberg-Solomon,Rachael Z, AU - Schatzkin,Arthur, AU - Hollenbeck,Albert R, AU - Sinha,Rashmi, AU - Ward,Mary H, Y1 - 2011/06/17/ PY - 2011/6/21/entrez PY - 2011/6/21/pubmed PY - 2011/9/21/medline SP - 305 EP - 15 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 174 IS - 3 N2 - Nitrate and nitrite are precursors of N-nitroso compounds, which induce tumors of the pancreas in animals. The authors evaluated the relation of dietary nitrate and nitrite to pancreatic cancer risk in the NIH-AARP Diet and Health Study. Nitrate and nitrite intakes were assessed at baseline using a 124-item food frequency questionnaire. During approximately 10 years of follow-up between 1995 and 2006, 1,728 incident pancreatic cancer cases were identified. There was no association between total nitrate or nitrite intake and pancreatic cancer in men or women. However, men in the highest quintile of summed nitrate/nitrite intake from processed meat had a nonsignificantly elevated risk of pancreatic cancer (hazard ratio = 1.18, 95% confidence interval: 0.95, 1.47; P-trend = 0.11). The authors observed a stronger increase in risk among men for nitrate/nitrite intake from processed meat at ages 12-13 years (highest quintile vs. lowest: hazard ratio = 1.32, 95% confidence interval: 0.99, 1.76; P-trend = 0.11), though the relation did not achieve statistical significance. The authors found no associations between adult or adolescent nitrate or nitrite intake from processed meats and pancreatic cancer among women. These results provide modest evidence that processed meat sources of dietary nitrate and nitrite may be associated with pancreatic cancer among men and provide no support for the hypothesis in women. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/21685410/Pancreatic_cancer_and_exposure_to_dietary_nitrate_and_nitrite_in_the_NIH_AARP_Diet_and_Health_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwr092 DB - PRIME DP - Unbound Medicine ER -