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The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals.
Crit Care Med. 2011 Jul; 39(7):1675-82.CC

Abstract

OBJECTIVE

Our aim was to determine the frequency and the clinical and epidemiologic characteristics of sepsis in a hospital-based population in Colombia.

DESIGN

Prospective cohort.

SETTING

Ten general hospitals in the four main cities of Colombia.

PATIENTS

Consecutive patients admitted in emergency rooms, intensive care units, and general wards from September 1, 2007, to February 29, 2008, with confirmation of infection according to the Centers for Disease Control and Prevention definitions.

INTERVENTIONS

None.

MEASUREMENTS AND MAIN RESULTS

The following information was recorded: demographic, clinical, and microbiologic characteristics; Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores; requirement for intensive care unit; length of stay; and 28-day all-cause mortality. During a period of 6 months, 2,681 patients were recruited: 69% and 31% with community-acquired and hospital-acquired infections, respectively. The mean age was 55 yrs (SD = 21), 51% were female, and the median length of stay was 10 days (interquartile range, 5-19). The mean Acute Physiology and Chronic Health Evaluation score was 11.5 (SD = 7) and the mean Sequential Organ Failure Assessment score was 3.8 (SD = 3). A total of 422 patients with community-acquired infections (16%) were admitted to the intensive care unit as a consequence of their infection and the median length of stay was 4.5 days in the intensive care unit. At admission, 2516 patients (94%) met at least one sepsis criterion and 1,658 (62%) met at least one criterion for severe sepsis. Overall, the 28-day mortality rates of patients with infection without sepsis, sepsis without organ dysfunction, severe sepsis without shock, and septic shock were 3%, 7.3%, 21.9%, and 45.6%, respectively. In community-acquired infections, the most frequent diagnosis was urinary tract infection in 28.6% followed by pneumonia in 22.8% and soft tissue infections in 21.8%. Within hospital-acquired infections, pneumonia was the most frequent diagnosis in 26.6% followed by urinary tract infection in 20.4% and soft tissue infections in 17.4%.

CONCLUSIONS

In a general inpatient population of Colombia, the rates of severe sepsis and septic shock are higher than those reported in the literature. The observed mortality is higher than the predicted by the Acute Physiology and Chronic Health Evaluation II score.

Authors+Show Affiliations

Universidad de Antioquia, Medellín, Colombia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21685740

Citation

Rodríguez, Ferney, et al. "The Epidemiology of Sepsis in Colombia: a Prospective Multicenter Cohort Study in Ten University Hospitals." Critical Care Medicine, vol. 39, no. 7, 2011, pp. 1675-82.
Rodríguez F, Barrera L, De La Rosa G, et al. The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals. Crit Care Med. 2011;39(7):1675-82.
Rodríguez, F., Barrera, L., De La Rosa, G., Dennis, R., Dueñas, C., Granados, M., Londoño, D., Molina, F., Ortiz, G., & Jaimes, F. (2011). The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals. Critical Care Medicine, 39(7), 1675-82. https://doi.org/10.1097/CCM.0b013e318218a35e
Rodríguez F, et al. The Epidemiology of Sepsis in Colombia: a Prospective Multicenter Cohort Study in Ten University Hospitals. Crit Care Med. 2011;39(7):1675-82. PubMed PMID: 21685740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals. AU - Rodríguez,Ferney, AU - Barrera,Lena, AU - De La Rosa,Gisela, AU - Dennis,Rodolfo, AU - Dueñas,Carmelo, AU - Granados,Marcela, AU - Londoño,Dario, AU - Molina,Francisco, AU - Ortiz,Guillermo, AU - Jaimes,Fabián, PY - 2011/6/21/entrez PY - 2011/6/21/pubmed PY - 2011/9/29/medline SP - 1675 EP - 82 JF - Critical care medicine JO - Crit Care Med VL - 39 IS - 7 N2 - OBJECTIVE: Our aim was to determine the frequency and the clinical and epidemiologic characteristics of sepsis in a hospital-based population in Colombia. DESIGN: Prospective cohort. SETTING: Ten general hospitals in the four main cities of Colombia. PATIENTS: Consecutive patients admitted in emergency rooms, intensive care units, and general wards from September 1, 2007, to February 29, 2008, with confirmation of infection according to the Centers for Disease Control and Prevention definitions. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The following information was recorded: demographic, clinical, and microbiologic characteristics; Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores; requirement for intensive care unit; length of stay; and 28-day all-cause mortality. During a period of 6 months, 2,681 patients were recruited: 69% and 31% with community-acquired and hospital-acquired infections, respectively. The mean age was 55 yrs (SD = 21), 51% were female, and the median length of stay was 10 days (interquartile range, 5-19). The mean Acute Physiology and Chronic Health Evaluation score was 11.5 (SD = 7) and the mean Sequential Organ Failure Assessment score was 3.8 (SD = 3). A total of 422 patients with community-acquired infections (16%) were admitted to the intensive care unit as a consequence of their infection and the median length of stay was 4.5 days in the intensive care unit. At admission, 2516 patients (94%) met at least one sepsis criterion and 1,658 (62%) met at least one criterion for severe sepsis. Overall, the 28-day mortality rates of patients with infection without sepsis, sepsis without organ dysfunction, severe sepsis without shock, and septic shock were 3%, 7.3%, 21.9%, and 45.6%, respectively. In community-acquired infections, the most frequent diagnosis was urinary tract infection in 28.6% followed by pneumonia in 22.8% and soft tissue infections in 21.8%. Within hospital-acquired infections, pneumonia was the most frequent diagnosis in 26.6% followed by urinary tract infection in 20.4% and soft tissue infections in 17.4%. CONCLUSIONS: In a general inpatient population of Colombia, the rates of severe sepsis and septic shock are higher than those reported in the literature. The observed mortality is higher than the predicted by the Acute Physiology and Chronic Health Evaluation II score. SN - 1530-0293 UR - https://www.unboundmedicine.com/medline/citation/21685740/The_epidemiology_of_sepsis_in_Colombia:_a_prospective_multicenter_cohort_study_in_ten_university_hospitals_ L2 - https://dx.doi.org/10.1097/CCM.0b013e318218a35e DB - PRIME DP - Unbound Medicine ER -