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Intrahospital weight and aerobic training in children with cystic fibrosis: a randomized controlled trial.
Med Sci Sports Exerc 2012; 44(1):2-11MS

Abstract

PURPOSE

The purpose of our study was to assess the effects of an 8-wk intrahospital combined circuit weight and aerobic training program performed by children with cystic fibrosis (of low-moderate severity and stable clinical condition) on the following outcomes: cardiorespiratory fitness (VO2peak) and muscle strength (five-repetition maximum (5RM) bench press, 5RM leg press, and 5RM seated row) (primary outcomes) and pulmonary function (forced vital capacity, forced expiratory volume in 1 s), weight, body composition, functional mobility (Timed Up and Down Stairs and 3-m Timed Up and Go tests), and quality of life (secondary outcomes). We also determined the effects of a detraining period (4 wk) on the aforementioned outcomes.

METHODS

We performed a randomized controlled trial design. Eleven participants in each group (controls: 7 boys, age = 11 ± 3 yr, body mass index = 17.2 ± 0.8 kg · m(-2) (mean ± SEM); intervention: 6 boys, age = 10 ± 2 yr, body mass index = 18.4 ± 1.0 kg · m(-2)) started the study.

RESULTS

Adherence to training averaged 95.1% ± 7.4%. We observed a significant group × time interaction effect (P = 0.036) for VO2peak. In the intervention group, VO2peak significantly increased with training by 3.9 mL · kg(-1) · min(-1) (95% confidence interval = 1.8-6.1 mL · kg(-1) · min(-1), P = 0.002), whereas it decreased during the detraining period (-3.4 mL · kg(-1) · min(-1), 95% confidence interval = -5.7 to -1.7 mL · kg(-1) · min(-1), P = 0.001). In contrast, no significant changes were observed during the study period within the control group. Although significant improvements were also observed after training for all 5RM strength tests (P < 0.001 for the interaction effect), the training improvements were not significantly decreased after the detraining period in the intervention group (all P > 0.1 for after training vs detraining). We found no significant training benefits in any of the secondary outcomes.

CONCLUSIONS

A short-term combined circuit weight and aerobic training program performed in a hospital setting induces significant benefits in the cardiorespiratory fitness and muscle strength of children with cystic fibrosis.

Authors+Show Affiliations

European University of Madrid, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21685814

Citation

Santana Sosa, Elena, et al. "Intrahospital Weight and Aerobic Training in Children With Cystic Fibrosis: a Randomized Controlled Trial." Medicine and Science in Sports and Exercise, vol. 44, no. 1, 2012, pp. 2-11.
Santana Sosa E, Groeneveld IF, Gonzalez-Saiz L, et al. Intrahospital weight and aerobic training in children with cystic fibrosis: a randomized controlled trial. Med Sci Sports Exerc. 2012;44(1):2-11.
Santana Sosa, E., Groeneveld, I. F., Gonzalez-Saiz, L., López-Mojares, L. M., Villa-Asensi, J. R., Barrio Gonzalez, M. I., ... Lucia, A. (2012). Intrahospital weight and aerobic training in children with cystic fibrosis: a randomized controlled trial. Medicine and Science in Sports and Exercise, 44(1), pp. 2-11. doi:10.1249/MSS.0b013e318228c302.
Santana Sosa E, et al. Intrahospital Weight and Aerobic Training in Children With Cystic Fibrosis: a Randomized Controlled Trial. Med Sci Sports Exerc. 2012;44(1):2-11. PubMed PMID: 21685814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrahospital weight and aerobic training in children with cystic fibrosis: a randomized controlled trial. AU - Santana Sosa,Elena, AU - Groeneveld,Iris F, AU - Gonzalez-Saiz,Laura, AU - López-Mojares,Luis M, AU - Villa-Asensi,José R, AU - Barrio Gonzalez,María I, AU - Fleck,Steven J, AU - Pérez,Margarita, AU - Lucia,Alejandro, PY - 2011/6/21/entrez PY - 2011/6/21/pubmed PY - 2012/4/26/medline SP - 2 EP - 11 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 44 IS - 1 N2 - PURPOSE: The purpose of our study was to assess the effects of an 8-wk intrahospital combined circuit weight and aerobic training program performed by children with cystic fibrosis (of low-moderate severity and stable clinical condition) on the following outcomes: cardiorespiratory fitness (VO2peak) and muscle strength (five-repetition maximum (5RM) bench press, 5RM leg press, and 5RM seated row) (primary outcomes) and pulmonary function (forced vital capacity, forced expiratory volume in 1 s), weight, body composition, functional mobility (Timed Up and Down Stairs and 3-m Timed Up and Go tests), and quality of life (secondary outcomes). We also determined the effects of a detraining period (4 wk) on the aforementioned outcomes. METHODS: We performed a randomized controlled trial design. Eleven participants in each group (controls: 7 boys, age = 11 ± 3 yr, body mass index = 17.2 ± 0.8 kg · m(-2) (mean ± SEM); intervention: 6 boys, age = 10 ± 2 yr, body mass index = 18.4 ± 1.0 kg · m(-2)) started the study. RESULTS: Adherence to training averaged 95.1% ± 7.4%. We observed a significant group × time interaction effect (P = 0.036) for VO2peak. In the intervention group, VO2peak significantly increased with training by 3.9 mL · kg(-1) · min(-1) (95% confidence interval = 1.8-6.1 mL · kg(-1) · min(-1), P = 0.002), whereas it decreased during the detraining period (-3.4 mL · kg(-1) · min(-1), 95% confidence interval = -5.7 to -1.7 mL · kg(-1) · min(-1), P = 0.001). In contrast, no significant changes were observed during the study period within the control group. Although significant improvements were also observed after training for all 5RM strength tests (P < 0.001 for the interaction effect), the training improvements were not significantly decreased after the detraining period in the intervention group (all P > 0.1 for after training vs detraining). We found no significant training benefits in any of the secondary outcomes. CONCLUSIONS: A short-term combined circuit weight and aerobic training program performed in a hospital setting induces significant benefits in the cardiorespiratory fitness and muscle strength of children with cystic fibrosis. SN - 1530-0315 UR - https://www.unboundmedicine.com/medline/citation/21685814/Intrahospital_weight_and_aerobic_training_in_children_with_cystic_fibrosis:__a_randomized_controlled_trial_ L2 - http://Insights.ovid.com/pubmed?pmid=21685814 DB - PRIME DP - Unbound Medicine ER -