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The role of antioxidant therapy in the treatment of male infertility: an overview.

Abstract

In recent years, many studies have focused on the effect of oxidative stress, reactive oxygen species (ROS) and antioxidants on the male eproductive system. Under physiological conditions, sperm produces small amounts of ROS, which are needed for fertilisation, acrosome reaction and capacitation. However, if an increased production of ROS is not associated with a similar increase in scavenging systems, peroxidative damage of the sperm plasma membrane and loss of DNA integrity typically occur, which leads to cell death and reduced fertility. Furthermore, since there is no linear correlation between sperm quality and pregnancy rates, an improvement in semen parameters should not be the sole outcome considered in studies of antioxidant therapies. A definitive conclusion regarding the benefit of these therapies is difficult to obtain, as most of the previous studies lacked control groups, considered different antioxidants in different combinations and doses, or did not evaluate pregnancy rates in previously infertile couples. Even if beneficial effects were reported in a few cases of male infertility, more multicentre, double-blind studies performed with the same criteria are necessary for an increased understanding of the effects of various antioxidants on fertility.

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  • Authors+Show Affiliations

    ,

    Department of Experimental Medicine, Policlinico Umberto I, University of Rome La Sapienza, Rome 00161, Italy. andrea.lenzi@uniroma1.it

    , , , ,

    Source

    Asian journal of andrology 13:5 2011 Sep pg 690-7

    MeSH

    Antioxidants
    Humans
    Infertility, Male
    Male
    Reactive Oxygen Species

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21685925

    Citation

    Lombardo, Francesco, et al. "The Role of Antioxidant Therapy in the Treatment of Male Infertility: an Overview." Asian Journal of Andrology, vol. 13, no. 5, 2011, pp. 690-7.
    Lombardo F, Sansone A, Romanelli F, et al. The role of antioxidant therapy in the treatment of male infertility: an overview. Asian J Androl. 2011;13(5):690-7.
    Lombardo, F., Sansone, A., Romanelli, F., Paoli, D., Gandini, L., & Lenzi, A. (2011). The role of antioxidant therapy in the treatment of male infertility: an overview. Asian Journal of Andrology, 13(5), pp. 690-7. doi:10.1038/aja.2010.183.
    Lombardo F, et al. The Role of Antioxidant Therapy in the Treatment of Male Infertility: an Overview. Asian J Androl. 2011;13(5):690-7. PubMed PMID: 21685925.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The role of antioxidant therapy in the treatment of male infertility: an overview. AU - Lombardo,Francesco, AU - Sansone,Andrea, AU - Romanelli,Francesco, AU - Paoli,Donatella, AU - Gandini,Loredana, AU - Lenzi,Andrea, Y1 - 2011/06/20/ PY - 2011/6/21/entrez PY - 2011/6/21/pubmed PY - 2011/12/28/medline SP - 690 EP - 7 JF - Asian journal of andrology JO - Asian J. Androl. VL - 13 IS - 5 N2 - In recent years, many studies have focused on the effect of oxidative stress, reactive oxygen species (ROS) and antioxidants on the male eproductive system. Under physiological conditions, sperm produces small amounts of ROS, which are needed for fertilisation, acrosome reaction and capacitation. However, if an increased production of ROS is not associated with a similar increase in scavenging systems, peroxidative damage of the sperm plasma membrane and loss of DNA integrity typically occur, which leads to cell death and reduced fertility. Furthermore, since there is no linear correlation between sperm quality and pregnancy rates, an improvement in semen parameters should not be the sole outcome considered in studies of antioxidant therapies. A definitive conclusion regarding the benefit of these therapies is difficult to obtain, as most of the previous studies lacked control groups, considered different antioxidants in different combinations and doses, or did not evaluate pregnancy rates in previously infertile couples. Even if beneficial effects were reported in a few cases of male infertility, more multicentre, double-blind studies performed with the same criteria are necessary for an increased understanding of the effects of various antioxidants on fertility. SN - 1745-7262 UR - https://www.unboundmedicine.com/medline/citation/21685925/The_role_of_antioxidant_therapy_in_the_treatment_of_male_infertility:_an_overview_ L2 - http://www.asiaandro.com/Abstract.asp?doi=10.1038/aja.2010.183 DB - PRIME DP - Unbound Medicine ER -