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Histopathology of alopecia areata, acute and chronic: Why is it important to the clinician?
Dermatol Ther. 2011 May-Jun; 24(3):369-74.DT

Abstract

Alopecia areata (AA) is often easy to diagnose but a scalp biopsy for horizontal sectioning is routine in this research clinic. The characteristic histological feature of AA is the peribulbar and intrabulbar mononuclear cell infiltrate, which occurs in the acute stage of the disease but may be absent in biopsies taken at a later stage. AA evolves through acute, subacute, chronic, and recovery phases. Increased numbers of terminal catagen and telogen hairs are found in the acute and perhaps subacute stages with increased numbers of miniaturized, vellus-like hairs in the subacute and chronic stages. Thus, it is important for clinicians and pathologists to recognize the different phases of AA, so that in the absence of the classic findings of a peribulbar lymphocytic infiltrate, a diagnosis of AA can still confidently be made.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Dy LC
Rush University Medical Center, Chicago, Illinois, USA.
Whiting DA
No affiliation info available

MeSH

Acute DiseaseAlopecia AreataChronic DiseaseDiagnosis, DifferentialHairHair FollicleHumansLeukocytes, MononuclearScalp

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21689247

Citation

Dy, Lady C., and David A. Whiting. "Histopathology of Alopecia Areata, Acute and Chronic: Why Is It Important to the Clinician?" Dermatologic Therapy, vol. 24, no. 3, 2011, pp. 369-74.
Dy LC, Whiting DA. Histopathology of alopecia areata, acute and chronic: Why is it important to the clinician? Dermatol Ther. 2011;24(3):369-74.
Dy, L. C., & Whiting, D. A. (2011). Histopathology of alopecia areata, acute and chronic: Why is it important to the clinician? Dermatologic Therapy, 24(3), 369-74. https://doi.org/10.1111/j.1529-8019.2011.01414.x
Dy LC, Whiting DA. Histopathology of Alopecia Areata, Acute and Chronic: Why Is It Important to the Clinician. Dermatol Ther. 2011 May-Jun;24(3):369-74. PubMed PMID: 21689247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histopathology of alopecia areata, acute and chronic: Why is it important to the clinician? AU - Dy,Lady C, AU - Whiting,David A, PY - 2011/6/22/entrez PY - 2011/6/22/pubmed PY - 2011/10/22/medline SP - 369 EP - 74 JF - Dermatologic therapy JO - Dermatol Ther VL - 24 IS - 3 N2 - Alopecia areata (AA) is often easy to diagnose but a scalp biopsy for horizontal sectioning is routine in this research clinic. The characteristic histological feature of AA is the peribulbar and intrabulbar mononuclear cell infiltrate, which occurs in the acute stage of the disease but may be absent in biopsies taken at a later stage. AA evolves through acute, subacute, chronic, and recovery phases. Increased numbers of terminal catagen and telogen hairs are found in the acute and perhaps subacute stages with increased numbers of miniaturized, vellus-like hairs in the subacute and chronic stages. Thus, it is important for clinicians and pathologists to recognize the different phases of AA, so that in the absence of the classic findings of a peribulbar lymphocytic infiltrate, a diagnosis of AA can still confidently be made. SN - 1529-8019 UR - https://www.unboundmedicine.com/medline/citation/21689247/Histopathology_of_alopecia_areata_acute_and_chronic:_Why_is_it_important_to_the_clinician DB - PRIME DP - Unbound Medicine ER -