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Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: a randomized crossover study.
Pulm Pharmacol Ther. 2011 Oct; 24(5):617-24.PP

Abstract

BACKGROUND

The addition of transdermal tulobuterol (Tulo) to inhaled tiotropium bromide (Tio) produced beneficial effects on spirometry-assessed parameters of respiratory function, disease-related symptoms and quality of life in patients with chronic obstructive pulmonary disease (COPD).

AIM

To compare the effects of Tio plus Tulo versus Tio alone on peripheral airway obstruction and quality of life in Japanese patients with COPD using impulse oscillation system (IOS)-assessed measures.

PATIENTS AND METHODS

Patients aged 50-80 years with clinically stable COPD and a forced expiratory volume in 1 s (FEV(1)) that was 30-80% of the predicted value were randomized to receive Tio 18 μg once daily, or combination therapy with Tio 18 μg once daily plus Tulo 2 mg once daily for 4 weeks. Patients then switched treatments for a further 4 weeks.

RESULTS

Sixteen patients completed the study. Tio plus Tulo was associated with significantly greater improvements than Tio in IOS-assessed markers of resistance (R5 and R5-R20), reactance and reactance area, from baseline to week 4. Both treatments significantly improved these markers over the 4-week treatment period, with the exception of R20 for which improvements were not significant. Tio plus Tulo improved symptoms of dyspnea to a significantly greater extent than Tio alone. St. George's Respiratory Questionnaire Score-Total was not significantly different between the two groups, but improvement from baseline in the 'impact' component was significantly greater with Tio plus Tulo than with Tio alone.

CONCLUSIONS

Coadministration of transdermal Tulo with inhaled Tio, as well as Tio alone, is associated with beneficial effects on IOS-assessed measures of peripheral airway obstruction in patients with COPD.

Authors+Show Affiliations

Division of Respiratory Medicine, Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21689775

Citation

Abe, Tetsuya, et al. "Effects of Inhaled Tiotropium Plus Transdermal Tulobuterol Versus Tiotropium Alone On Impulse Oscillation System (IOS)-assessed Measures of Peripheral Airway Resistance and Reactance, Lung Function and Quality of Life in Patients With COPD: a Randomized Crossover Study." Pulmonary Pharmacology & Therapeutics, vol. 24, no. 5, 2011, pp. 617-24.
Abe T, Setoguchi Y, Kono Y, et al. Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: a randomized crossover study. Pulm Pharmacol Ther. 2011;24(5):617-24.
Abe, T., Setoguchi, Y., Kono, Y., Togashi, Y., Sugiyama, S., Tanakadate, M., Soeda, S., Nakai, M., Sugiyama, N., Fujiwara, A., Yamaguchi, K., Yamaguchi, A., & Kurita, N. (2011). Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: a randomized crossover study. Pulmonary Pharmacology & Therapeutics, 24(5), 617-24. https://doi.org/10.1016/j.pupt.2011.06.002
Abe T, et al. Effects of Inhaled Tiotropium Plus Transdermal Tulobuterol Versus Tiotropium Alone On Impulse Oscillation System (IOS)-assessed Measures of Peripheral Airway Resistance and Reactance, Lung Function and Quality of Life in Patients With COPD: a Randomized Crossover Study. Pulm Pharmacol Ther. 2011;24(5):617-24. PubMed PMID: 21689775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: a randomized crossover study. AU - Abe,Tetsuya, AU - Setoguchi,Yasuhiro, AU - Kono,Yuta, AU - Togashi,Yuhki, AU - Sugiyama,Shinya, AU - Tanakadate,Motochika, AU - Soeda,Seiko, AU - Nakai,Michiko, AU - Sugiyama,Norihiro, AU - Fujiwara,Akahito, AU - Yamaguchi,Kouichi, AU - Yamaguchi,Aya, AU - Kurita,Nao, Y1 - 2011/06/13/ PY - 2010/11/25/received PY - 2011/05/24/revised PY - 2011/06/03/accepted PY - 2011/6/22/entrez PY - 2011/6/22/pubmed PY - 2012/1/6/medline SP - 617 EP - 24 JF - Pulmonary pharmacology & therapeutics JO - Pulm Pharmacol Ther VL - 24 IS - 5 N2 - BACKGROUND: The addition of transdermal tulobuterol (Tulo) to inhaled tiotropium bromide (Tio) produced beneficial effects on spirometry-assessed parameters of respiratory function, disease-related symptoms and quality of life in patients with chronic obstructive pulmonary disease (COPD). AIM: To compare the effects of Tio plus Tulo versus Tio alone on peripheral airway obstruction and quality of life in Japanese patients with COPD using impulse oscillation system (IOS)-assessed measures. PATIENTS AND METHODS: Patients aged 50-80 years with clinically stable COPD and a forced expiratory volume in 1 s (FEV(1)) that was 30-80% of the predicted value were randomized to receive Tio 18 μg once daily, or combination therapy with Tio 18 μg once daily plus Tulo 2 mg once daily for 4 weeks. Patients then switched treatments for a further 4 weeks. RESULTS: Sixteen patients completed the study. Tio plus Tulo was associated with significantly greater improvements than Tio in IOS-assessed markers of resistance (R5 and R5-R20), reactance and reactance area, from baseline to week 4. Both treatments significantly improved these markers over the 4-week treatment period, with the exception of R20 for which improvements were not significant. Tio plus Tulo improved symptoms of dyspnea to a significantly greater extent than Tio alone. St. George's Respiratory Questionnaire Score-Total was not significantly different between the two groups, but improvement from baseline in the 'impact' component was significantly greater with Tio plus Tulo than with Tio alone. CONCLUSIONS: Coadministration of transdermal Tulo with inhaled Tio, as well as Tio alone, is associated with beneficial effects on IOS-assessed measures of peripheral airway obstruction in patients with COPD. SN - 1522-9629 UR - https://www.unboundmedicine.com/medline/citation/21689775/Effects_of_inhaled_tiotropium_plus_transdermal_tulobuterol_versus_tiotropium_alone_on_impulse_oscillation_system__IOS__assessed_measures_of_peripheral_airway_resistance_and_reactance_lung_function_and_quality_of_life_in_patients_with_COPD:_a_randomized_crossover_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1094-5539(11)00119-2 DB - PRIME DP - Unbound Medicine ER -