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Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland.
Vet Parasitol. 2011 Dec 15; 182(2-4):372-7.VP

Abstract

In order to assess the resistance situation against macrocyclic lactones in Parascaris equorum and against tetrahydropyrimidine derivatives in strongyles in Finnish trotter horses, 112 foals on 18 farms, mostly 1 year old, were examined for these parasites with a modified McMaster faecal flotation method. P. equorum positive foals (n=24) were given ivermectin orally at a dose of 200 μg/kg b.w., while strongyle positive but P. equorum negative foals (n=38) received pyrantel embonate orally at a dose of 19 mg/kg. Sixteen P. equorum infected foals, treated with ivermectin, also harboured strongyles. During the anthelmintic treatment visit to the farm, Faecal Egg Count Reduction Test (FECRT) reference (first) samples were collected. Fourteen days later, the second sampling (reduction samples) was done. The FECR was calculated for each foal/parasite combination. The reduction efficacies of ivermectin against P. equorum (mean 52%, calculated from the individual egg count reductions) and pyrantel against strongyles (43%) were strongly indicative of widespread resistance. Also indication of ivermectin resistance among strongyles was seen. The widespread use of anthelmintics for Finnish horses obviously has resulted in resistance, as has happened elsewhere, too.

Authors+Show Affiliations

Department of Veterinary Biosciences, Faculty of Veterinary Medicine (FINPAR), PO Box 66, 00014 University of Helsinki, Finland. anu.nareaho@helsinki.fiNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21689886

Citation

Näreaho, A, et al. "Impaired Efficacy of Ivermectin Against Parascaris Equorum, and Both Ivermectin and Pyrantel Against Strongyle Infections in Trotter Foals in Finland." Veterinary Parasitology, vol. 182, no. 2-4, 2011, pp. 372-7.
Näreaho A, Vainio K, Oksanen A. Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland. Vet Parasitol. 2011;182(2-4):372-7.
Näreaho, A., Vainio, K., & Oksanen, A. (2011). Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland. Veterinary Parasitology, 182(2-4), 372-7. https://doi.org/10.1016/j.vetpar.2011.05.045
Näreaho A, Vainio K, Oksanen A. Impaired Efficacy of Ivermectin Against Parascaris Equorum, and Both Ivermectin and Pyrantel Against Strongyle Infections in Trotter Foals in Finland. Vet Parasitol. 2011 Dec 15;182(2-4):372-7. PubMed PMID: 21689886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland. AU - Näreaho,A, AU - Vainio,K, AU - Oksanen,A, Y1 - 2011/05/31/ PY - 2011/01/14/received PY - 2011/05/13/revised PY - 2011/05/24/accepted PY - 2011/6/22/entrez PY - 2011/6/22/pubmed PY - 2012/3/16/medline SP - 372 EP - 7 JF - Veterinary parasitology JO - Vet Parasitol VL - 182 IS - 2-4 N2 - In order to assess the resistance situation against macrocyclic lactones in Parascaris equorum and against tetrahydropyrimidine derivatives in strongyles in Finnish trotter horses, 112 foals on 18 farms, mostly 1 year old, were examined for these parasites with a modified McMaster faecal flotation method. P. equorum positive foals (n=24) were given ivermectin orally at a dose of 200 μg/kg b.w., while strongyle positive but P. equorum negative foals (n=38) received pyrantel embonate orally at a dose of 19 mg/kg. Sixteen P. equorum infected foals, treated with ivermectin, also harboured strongyles. During the anthelmintic treatment visit to the farm, Faecal Egg Count Reduction Test (FECRT) reference (first) samples were collected. Fourteen days later, the second sampling (reduction samples) was done. The FECR was calculated for each foal/parasite combination. The reduction efficacies of ivermectin against P. equorum (mean 52%, calculated from the individual egg count reductions) and pyrantel against strongyles (43%) were strongly indicative of widespread resistance. Also indication of ivermectin resistance among strongyles was seen. The widespread use of anthelmintics for Finnish horses obviously has resulted in resistance, as has happened elsewhere, too. SN - 1873-2550 UR - https://www.unboundmedicine.com/medline/citation/21689886/Impaired_efficacy_of_ivermectin_against_Parascaris_equorum_and_both_ivermectin_and_pyrantel_against_strongyle_infections_in_trotter_foals_in_Finland_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(11)00414-6 DB - PRIME DP - Unbound Medicine ER -