Tags

Type your tag names separated by a space and hit enter

Folic acid use in pregnancy and the development of atopy, asthma, and lung function in childhood.
Pediatrics. 2011 Jul; 128(1):e135-44.Ped

Abstract

BACKGROUND

Recently, folic acid supplementation during pregnancy was implicated as a potential risk factor for atopic diseases in childhood.

OBJECTIVE

To investigate whether folic acid supplementation and higher intracellular folic acid (ICF) levels during pregnancy increase the risk of childhood atopic diseases.

METHODS

In the KOALA Birth Cohort Study (N=2834), data on eczema and wheeze were collected by using repeated questionnaires at 3, 7, 12, and 24 months, 4 to 5 years, and 6 to 7 years after delivery. Atopic dermatitis and total and specific immunoglobulin E levels were determined at age 2 years and asthma and lung function at age 6 to 7 years. We defined folic acid use as stand-alone and/or multivitamin supplements according to the period of use before and/or during pregnancy. ICF levels were determined in blood samples taken at ∼35 weeks of pregnancy (n=837). Multivariable logistic and linear regression analyses were conducted, with generalized estimating equation models for repeated outcomes.

RESULTS

Maternal folic acid supplement use during pregnancy was not associated with increased risk of wheeze, lung function, asthma, or related atopic outcomes in the offspring. Maternal ICF level in late pregnancy was inversely associated with asthma risk at age 6 to 7 years in a dose-dependent manner (P for trend=.05).

CONCLUSIONS

Our results do not confirm any meaningful association between folic acid supplement use during pregnancy and atopic diseases in the offspring. Higher ICF levels in pregnancy tended, at most, toward a small decreased risk for developing asthma.

Authors+Show Affiliations

Department of Epidemiology, Maastricht University, CAPHRI School for Public Health and Primary Care, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21690114

Citation

Magdelijns, Fabienne J H., et al. "Folic Acid Use in Pregnancy and the Development of Atopy, Asthma, and Lung Function in Childhood." Pediatrics, vol. 128, no. 1, 2011, pp. e135-44.
Magdelijns FJ, Mommers M, Penders J, et al. Folic acid use in pregnancy and the development of atopy, asthma, and lung function in childhood. Pediatrics. 2011;128(1):e135-44.
Magdelijns, F. J., Mommers, M., Penders, J., Smits, L., & Thijs, C. (2011). Folic acid use in pregnancy and the development of atopy, asthma, and lung function in childhood. Pediatrics, 128(1), e135-44. https://doi.org/10.1542/peds.2010-1690
Magdelijns FJ, et al. Folic Acid Use in Pregnancy and the Development of Atopy, Asthma, and Lung Function in Childhood. Pediatrics. 2011;128(1):e135-44. PubMed PMID: 21690114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid use in pregnancy and the development of atopy, asthma, and lung function in childhood. AU - Magdelijns,Fabienne J H, AU - Mommers,Monique, AU - Penders,John, AU - Smits,Luc, AU - Thijs,Carel, Y1 - 2011/06/20/ PY - 2011/6/22/entrez PY - 2011/6/22/pubmed PY - 2011/9/2/medline SP - e135 EP - 44 JF - Pediatrics JO - Pediatrics VL - 128 IS - 1 N2 - BACKGROUND: Recently, folic acid supplementation during pregnancy was implicated as a potential risk factor for atopic diseases in childhood. OBJECTIVE: To investigate whether folic acid supplementation and higher intracellular folic acid (ICF) levels during pregnancy increase the risk of childhood atopic diseases. METHODS: In the KOALA Birth Cohort Study (N=2834), data on eczema and wheeze were collected by using repeated questionnaires at 3, 7, 12, and 24 months, 4 to 5 years, and 6 to 7 years after delivery. Atopic dermatitis and total and specific immunoglobulin E levels were determined at age 2 years and asthma and lung function at age 6 to 7 years. We defined folic acid use as stand-alone and/or multivitamin supplements according to the period of use before and/or during pregnancy. ICF levels were determined in blood samples taken at ∼35 weeks of pregnancy (n=837). Multivariable logistic and linear regression analyses were conducted, with generalized estimating equation models for repeated outcomes. RESULTS: Maternal folic acid supplement use during pregnancy was not associated with increased risk of wheeze, lung function, asthma, or related atopic outcomes in the offspring. Maternal ICF level in late pregnancy was inversely associated with asthma risk at age 6 to 7 years in a dose-dependent manner (P for trend=.05). CONCLUSIONS: Our results do not confirm any meaningful association between folic acid supplement use during pregnancy and atopic diseases in the offspring. Higher ICF levels in pregnancy tended, at most, toward a small decreased risk for developing asthma. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/21690114/Folic_acid_use_in_pregnancy_and_the_development_of_atopy_asthma_and_lung_function_in_childhood_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=21690114 DB - PRIME DP - Unbound Medicine ER -