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Very early electrodiagnostic findings in Guillain-Barré syndrome.
J Peripher Nerv Syst. 2011 Jun; 16(2):136-42.JP

Abstract

Electrodiagnostic studies play a key role in the evaluation of patients with Guillain-Barré syndrome (GBS). However, at early stages patients may not meet current neurophysiologic criteria. We report electrodiagnostic findings for 18 patients with suspected GBS within 4 days of clinical onset. Fifteen patients (83%) showed abnormality in the motor nerve conduction study. Prolonged distal motor latency (DML) was the most frequent demyelinating parameter (seen in 55% of patients). Abnormal late responses were noted in 14 patients (77%). Electrodiagnostic study of cranial nerves was abnormal in eight (44%), and motor nerve conduction velocity was abnormal in only six patients (23%). The study shows a predominant motor neuropathy pattern followed by a sural-sparing pattern; no patients showed a strictly normal electrodiagnostic study. Reduced distal compound muscle action potential and prolonged DML in the demyelinating range were associated with severity of GBS on admission. After the electrodiagnostic study, 5 patients (27%) already fulfilled electrodiagnostic criteria for acute inflammatory demyelinating polyneuropathy (AIDP), 1 (5%) for the axonal variant of GBS, and 13 (72%) were classified as equivocal. We conclude that exhaustive electrodiagnostic studies of patients with suspected GBS in very early stages are useful in the diagnosis and management of the condition.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Albertí MA
Neuromuscular Unit, Neurology Department, Hospital Universitari de Bellvitge-IDIBELL, Barcelona, Spain.
Alentorn A
No affiliation info available
Martínez-Yelamos S
No affiliation info available
Martínez-Matos JA
No affiliation info available
Povedano M
No affiliation info available
Montero J
No affiliation info available
Casasnovas C
No affiliation info available

MeSH

Action PotentialsAdultEarly DiagnosisElectrodiagnosisFemaleGuillain-Barre SyndromeHumansMaleMiddle AgedNeural ConductionRetrospective Studies

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21692913

Citation

Albertí, Maria A., et al. "Very Early Electrodiagnostic Findings in Guillain-Barré Syndrome." Journal of the Peripheral Nervous System : JPNS, vol. 16, no. 2, 2011, pp. 136-42.
Albertí MA, Alentorn A, Martínez-Yelamos S, et al. Very early electrodiagnostic findings in Guillain-Barré syndrome. J Peripher Nerv Syst. 2011;16(2):136-42.
Albertí, M. A., Alentorn, A., Martínez-Yelamos, S., Martínez-Matos, J. A., Povedano, M., Montero, J., & Casasnovas, C. (2011). Very early electrodiagnostic findings in Guillain-Barré syndrome. Journal of the Peripheral Nervous System : JPNS, 16(2), 136-42. https://doi.org/10.1111/j.1529-8027.2011.00338.x
Albertí MA, et al. Very Early Electrodiagnostic Findings in Guillain-Barré Syndrome. J Peripher Nerv Syst. 2011;16(2):136-42. PubMed PMID: 21692913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Very early electrodiagnostic findings in Guillain-Barré syndrome. AU - Albertí,Maria A, AU - Alentorn,Agustí, AU - Martínez-Yelamos,Sergio, AU - Martínez-Matos,Juan A, AU - Povedano,Monica, AU - Montero,Jordi, AU - Casasnovas,Carlos, PY - 2011/6/23/entrez PY - 2011/6/23/pubmed PY - 2011/10/27/medline SP - 136 EP - 42 JF - Journal of the peripheral nervous system : JPNS JO - J Peripher Nerv Syst VL - 16 IS - 2 N2 - Electrodiagnostic studies play a key role in the evaluation of patients with Guillain-Barré syndrome (GBS). However, at early stages patients may not meet current neurophysiologic criteria. We report electrodiagnostic findings for 18 patients with suspected GBS within 4 days of clinical onset. Fifteen patients (83%) showed abnormality in the motor nerve conduction study. Prolonged distal motor latency (DML) was the most frequent demyelinating parameter (seen in 55% of patients). Abnormal late responses were noted in 14 patients (77%). Electrodiagnostic study of cranial nerves was abnormal in eight (44%), and motor nerve conduction velocity was abnormal in only six patients (23%). The study shows a predominant motor neuropathy pattern followed by a sural-sparing pattern; no patients showed a strictly normal electrodiagnostic study. Reduced distal compound muscle action potential and prolonged DML in the demyelinating range were associated with severity of GBS on admission. After the electrodiagnostic study, 5 patients (27%) already fulfilled electrodiagnostic criteria for acute inflammatory demyelinating polyneuropathy (AIDP), 1 (5%) for the axonal variant of GBS, and 13 (72%) were classified as equivocal. We conclude that exhaustive electrodiagnostic studies of patients with suspected GBS in very early stages are useful in the diagnosis and management of the condition. SN - 1529-8027 UR - https://www.unboundmedicine.com/medline/citation/21692913/Very_early_electrodiagnostic_findings_in_Guillain_Barré_syndrome_ DB - PRIME DP - Unbound Medicine ER -