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Degradation of pharmaceutical beta-blockers by electrochemical advanced oxidation processes using a flow plant with a solar compound parabolic collector.
Water Res. 2011 Aug; 45(14):4119-30.WR

Abstract

The degradation of the beta-blockers atenolol, metoprolol tartrate and propranolol hydrochloride was studied by electro-Fenton (EF) and solar photoelectro-Fenton (SPEF). Solutions of 10 L of 100 mg L⁻¹ of total organic carbon of each drug in 0.1 M Na₂SO₄ with 0.5 mM Fe²⁺ of pH 3.0 were treated in a recirculation flow plant with an electrochemical reactor coupled with a solar compound parabolic collector. Single Pt/carbon felt (CF) and boron-doped diamond (BDD)/air-diffusion electrode (ADE) cells and combined Pt/ADE-Pt/CF and BDD/ADE-Pt/CF cells were used. SPEF treatments were more potent with the latter cell, yielding 95-97% mineralization with 100% of maximum current efficiency and energy consumptions of about 0.250 kWh g TOC⁻¹. However, the Pt/ADE-Pt/CF cell gave much lower energy consumptions of about 0.080 kWh g TOC⁻¹ with slightly lower mineralization of 88-93%, then being more useful for its possible application at industrial level. The EF method led to a poorer mineralization and was more potent using the combined cells by the additional production of hydroxyl radicals (•OH) from Fenton's reaction from the fast Fe²⁺ regeneration at the CF cathode. Organics were also more rapidly destroyed at BDD than at Pt anode. The decay kinetics of beta-blockers always followed a pseudo first-order reaction, although in SPEF, it was accelerated by the additional production of •OH from the action of UV light of solar irradiation. Aromatic intermediates were also destroyed by hydroxyl radicals. Ultimate carboxylic acids like oxalic and oxamic remained in the treated solutions by EF, but their Fe(III) complexes were photolyzed by solar irradiation in SPEF, thus explaining its higher oxidation power. NO₃⁻ was the predominant inorganic ion lost in EF, whereas the SPEF process favored the production of NH₄⁺ ion and volatile N-derivatives.

Authors+Show Affiliations

Laboratori d'Electroquímica de Materials i del Medi Ambient, Departament de Química Física, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21693380

Citation

Isarain-Chávez, Eloy, et al. "Degradation of Pharmaceutical Beta-blockers By Electrochemical Advanced Oxidation Processes Using a Flow Plant With a Solar Compound Parabolic Collector." Water Research, vol. 45, no. 14, 2011, pp. 4119-30.
Isarain-Chávez E, Rodríguez RM, Cabot PL, et al. Degradation of pharmaceutical beta-blockers by electrochemical advanced oxidation processes using a flow plant with a solar compound parabolic collector. Water Res. 2011;45(14):4119-30.
Isarain-Chávez, E., Rodríguez, R. M., Cabot, P. L., Centellas, F., Arias, C., Garrido, J. A., & Brillas, E. (2011). Degradation of pharmaceutical beta-blockers by electrochemical advanced oxidation processes using a flow plant with a solar compound parabolic collector. Water Research, 45(14), 4119-30. https://doi.org/10.1016/j.watres.2011.05.026
Isarain-Chávez E, et al. Degradation of Pharmaceutical Beta-blockers By Electrochemical Advanced Oxidation Processes Using a Flow Plant With a Solar Compound Parabolic Collector. Water Res. 2011;45(14):4119-30. PubMed PMID: 21693380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Degradation of pharmaceutical beta-blockers by electrochemical advanced oxidation processes using a flow plant with a solar compound parabolic collector. AU - Isarain-Chávez,Eloy, AU - Rodríguez,Rosa María, AU - Cabot,Pere Lluís, AU - Centellas,Francesc, AU - Arias,Conchita, AU - Garrido,José Antonio, AU - Brillas,Enric, Y1 - 2011/05/31/ PY - 2011/02/24/received PY - 2011/05/09/revised PY - 2011/05/21/accepted PY - 2011/6/23/entrez PY - 2011/6/23/pubmed PY - 2011/10/20/medline SP - 4119 EP - 30 JF - Water research JO - Water Res. VL - 45 IS - 14 N2 - The degradation of the beta-blockers atenolol, metoprolol tartrate and propranolol hydrochloride was studied by electro-Fenton (EF) and solar photoelectro-Fenton (SPEF). Solutions of 10 L of 100 mg L⁻¹ of total organic carbon of each drug in 0.1 M Na₂SO₄ with 0.5 mM Fe²⁺ of pH 3.0 were treated in a recirculation flow plant with an electrochemical reactor coupled with a solar compound parabolic collector. Single Pt/carbon felt (CF) and boron-doped diamond (BDD)/air-diffusion electrode (ADE) cells and combined Pt/ADE-Pt/CF and BDD/ADE-Pt/CF cells were used. SPEF treatments were more potent with the latter cell, yielding 95-97% mineralization with 100% of maximum current efficiency and energy consumptions of about 0.250 kWh g TOC⁻¹. However, the Pt/ADE-Pt/CF cell gave much lower energy consumptions of about 0.080 kWh g TOC⁻¹ with slightly lower mineralization of 88-93%, then being more useful for its possible application at industrial level. The EF method led to a poorer mineralization and was more potent using the combined cells by the additional production of hydroxyl radicals (•OH) from Fenton's reaction from the fast Fe²⁺ regeneration at the CF cathode. Organics were also more rapidly destroyed at BDD than at Pt anode. The decay kinetics of beta-blockers always followed a pseudo first-order reaction, although in SPEF, it was accelerated by the additional production of •OH from the action of UV light of solar irradiation. Aromatic intermediates were also destroyed by hydroxyl radicals. Ultimate carboxylic acids like oxalic and oxamic remained in the treated solutions by EF, but their Fe(III) complexes were photolyzed by solar irradiation in SPEF, thus explaining its higher oxidation power. NO₃⁻ was the predominant inorganic ion lost in EF, whereas the SPEF process favored the production of NH₄⁺ ion and volatile N-derivatives. SN - 1879-2448 UR - https://www.unboundmedicine.com/medline/citation/21693380/Degradation_of_pharmaceutical_beta_blockers_by_electrochemical_advanced_oxidation_processes_using_a_flow_plant_with_a_solar_compound_parabolic_collector_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0043-1354(11)00289-2 DB - PRIME DP - Unbound Medicine ER -